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- W1969412616 abstract "Abstract The formation of new mitochondria in insect tissues occurs during discrete periods of cell growth associated with the molting cycles or metamorphosis. Acriflavine and ethidium bromide are known to disrupt replication, transcription and translation of circular, mitochondrial DNA during mitochondriogenesis. Injection of acriflavine into Heliothis zea during metamorphosis resulted in adult deformities and the loss of flight ability in normal appearing individuals. A 45% mortality rate was found for doses of 20 μg acriflavine/individual. Both acriflavine and ethidium bromide were toxic to neonate Aedes aegypti larvae. Acriflavine was most toxic with an LD 50 of 0.48 ppm, and larvae required only 12 hr of exposure for a maximal mortality response. Surviving larvae took up to three times longer to reach the pupal stage." @default.
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- W1969412616 date "1977-01-01" @default.
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- W1969412616 title "Toxic effects of mitochondrial DNA inhibitors on insect growth and development" @default.
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- W1969412616 doi "https://doi.org/10.1016/0022-1910(77)90266-9" @default.
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