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- W1969413270 abstract "The ciliated airway epithelial cell provides essential clearance of airway secretions and inhaled matter through the beating movement of cilia. This predominant cell type of the conducting airways is rendered susceptible by its location to various forms of injury, arising from pollutants, microbes, inflammatory cells, and their mediators. 1 Hastie AT Loegering DA Gleich GJ Kueppers F. The effect of purified human eosinophil major basic protein on mammalian ciliary activity. Am Rev Respir Dis. 1987; 135: 848-853 Crossref PubMed Scopus (93) Google Scholar ,2 Hingley ST Hastie AT Kueppers F Higgins ML Weinbaum G Shryock T. Effect of ciliostatic factors from Pseudomonas aeruginosa on rabbit respiratory cilia. Infect Immunol. 1986; 51: 254-262 PubMed Google Scholar With injury, ciliated cells can become denuded of cilia, but otherwise appear intact, or they may be irreparably injured and replaced by newly differentiating cells. 3 Nikula KJ Wilson DW Giri SN Plopper CG Dungworth DL. The response of the rat tracheal epithelium to ozone exposures: injury, adaptation, and repair. Am J Pathol. 1988; 131: 373-384 PubMed Google Scholar ,4 Leigh MW Carson JL Gambling TM Boat TF. Loss of cilia and altered phenotypic expression of ciliated cells after acute sulfur dioxide exposure. Chest. 1992; 101: 16S Abstract Full Text Full Text PDF PubMed Google Scholar Regeneration of cilia or ciliogenesis during differentiation presumably proceeds from self-assembly of the numerous axoneme constituents, including microtubules, dynein arms, radial spokes, etc. 5 Lefevbre PA Rosenbaum JL. Regulation of the synthesis and assembly of ciliary and flagellar proteins during regeneration. Ann Rev Cell Biol. 1986; 2: 517-546 Crossref Scopus (113) Google Scholar Length of the completed cilium is important for optimal propulsion of mucus. In sea urchin embryos denuded of cilia, length of regenerated cilia is apparently determined by synthesis of 1 of 3 filamentous proteins called tektins. 6 Stephens RE. Quantal tektin synthesis and ciliary length in sea-urchin embryos. J Cell Sci. 1989; 92: 403-413 Crossref PubMed Google Scholar Tektins resist solubilization in sarkosyl/urea and are biochemically similar to intermediate filaments. 7 Steffen W Linck RW. Tektins in ciliary and flagellar microtubules and their association with other cytoskeletal systems. Cell movement: Kinesin, dynein, and microtubule dynamics. Alan R. Liss, Inc, New York1989: 67-81 Google Scholar , 8 Steffen W Linck RW. Evidence for tektins in centrioles and axonemal microtubules. Proc Natl Acad Sci. 1988; 85: 2643-2647 Crossref PubMed Scopus (75) Google Scholar , 9 Steffen W Linck RW. Relationship between tektins and intermediate filament proteins: an immunological study. Cell Motil Cytoskel. 1989; 14: 359-371 Crossref PubMed Scopus (20) Google Scholar We have examined cilia obtained from bovine tracheal epithelium to ascertain the presence of tektins in mammalian cilia and to initiate study of their participation in ciliogenesis." @default.
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- W1969413270 date "1992-03-01" @default.
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- W1969413270 title "Initial Characterization of Tektins in Cilia of Respiratory Epithelial Cells" @default.
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- W1969413270 doi "https://doi.org/10.1378/chest.101.3_supplement.47s" @default.
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