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- W1969425623 abstract "ABSTRACT In this paper evidence is presented that a 27S Optical Density (O. D.) peak is absent and a 32S O. D. peak is regularly present on analysis of the soluble thyroid proteins of the goitrous rat. This occurs irrespective of the goitrogenic stimulus and a normal O. D. pattern can be restored by reversal of the goitrous process by thyroxine. In rats rendered goitrous by a low iodine diet or KClO 4 treatment, iodine supplementation also removed the 32S O. D. peak and resulted in reformation of the 27S peak. In rats treated by antithyroid drugs of the thiocarbamide group loss of the 32S O. D. peak was not associated with recovery of a 27S peak. This may be related to differences in potency of the various antithyroid drugs. 125 I and 3 H-leucine were not incorporated into the 32S O. D. peak material of the rat thyroid in vivo or into the 32S O. D. peak material of sheep thyroid slices in vitro . The view that this 32S O. D. peak was not iodoprotein nature was confirmed by showing that this peak had a maximal absorbance at 260 nm favouring the hypothesis that it was composed of nucleic acid." @default.
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- W1969425623 date "1970-09-01" @default.
- W1969425623 modified "2023-10-14" @default.
- W1969425623 title "FURTHER STUDIES ON THE 27S AND 32S OPTICAL DENSITY PEAKS OF THE RAT THYROID" @default.
- W1969425623 doi "https://doi.org/10.1530/acta.0.0650175" @default.
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