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- W1969426984 abstract "<h2>Abstract</h2> Parallel studies are presented of the amplification of biological and immunological responses to HCG through simultaneous treatment (or mixture of hormone) with semipurified extracts of rat cerebrocortical tissue. Gonadotropin-enhancing factors (GEF) reversed blockage of ovulation by reserpine in intact or hypophysectomized immature rats. A relationship between biological and immunological enhancement of HCG is indicated by determination that a marked increase in radioimmuno-binding of the hormone to anti-human-LH serum occurs when solutions of HCG and GEF which possess no detectable binding affinity are mixed. The same solutions had been employed in the analysis of uterotrophic potency in the immature mouse, in which assay no detectable response was obtained to either hormone or GEF alone, but in mixture produced a nearly maximal uterine weight. These combined results suggest a specific molecular interaction between gonadotropin and GEF. Possible mechanism(s) of action of GEF are discussed." @default.
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- W1969426984 date "1971-12-01" @default.
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- W1969426984 title "Gonadotropin-enhancing factors (GEF): III. A comparison of bioassays and radioimmunoassay in assessing GEF activity" @default.
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- W1969426984 doi "https://doi.org/10.1016/0010-7824(71)90051-5" @default.
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