FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969434539> ?p ?o ?g. }

• W1969434539 endingPage "1963" @default.
• W1969434539 startingPage "1954" @default.
• W1969434539 abstract "Altered levels of Substance P (SP), a neuropeptide endowed with neuroprotective and anti-apoptotic properties, were found in brain areas and spinal fluid of Alzheimer's disease (AD) patients. One of the hallmarks of AD is the abnormal extracellular deposition of neurotoxic beta amyloid (Aβ) peptides, derived from the proteolytic processing of amyloid precursor protein (APP). In the present study, we confirmed, the neurotrophic action of SP in cultured rat cerebellar granule cells (CGCs) and investigated its effects on APP metabolism. Incubation with low (5 mM) potassium induced apoptotic cell death of CGCs and amyloidogenic processing of APP, whereas treatment with SP (200 nM) reverted these effects via NK1 receptors. The non-amyloidogenic effect of SP consisted of reduction of Aβ(1-42), increase of sAPPα and enhanced α-secretase activity, without a significant change in steady-state levels of cellular APP. The intracellular mechanisms whereby SP alters APP metabolism were further investigated by measuring mRNA and/or steady-state protein levels of key enzymes involved with α-, β- and γ-secretase activity. Among them, Adam9, both at the mRNA and protein level, was the only enzyme to be significantly down-regulated following the induction of apoptosis (K5) and up-regulated after SP treatment. In addition to its neuroprotective properties, this study shows that SP is able to stimulate non-amyloidogenic APP processing, thereby reducing the possibility of generation of toxic Aβ peptides in brain." @default.
• W1969434539 created "2016-06-24" @default.
• W1969434539 creator A5005503268 @default.
• W1969434539 creator A5042162742 @default.
• W1969434539 creator A5054899915 @default.
• W1969434539 creator A5059406139 @default.
• W1969434539 creator A5087738067 @default.
• W1969434539 creator A5088595764 @default.
• W1969434539 creator A5089278763 @default.
• W1969434539 date "2012-04-01" @default.
• W1969434539 modified "2023-09-26" @default.
• W1969434539 title "Substance P activates ADAM9 mRNA expression and induces α-secretase-mediated amyloid precursor protein cleavage" @default.
• W1969434539 cites W1524643915 @default.
• W1969434539 cites W1535155979 @default.
• W1969434539 cites W1555938246 @default.
• W1969434539 cites W1755018410 @default.
• W1969434539 cites W1898172578 @default.
• W1969434539 cites W1964972074 @default.
• W1969434539 cites W1973026127 @default.
• W1969434539 cites W1984933995 @default.
• W1969434539 cites W1999514420 @default.
• W1969434539 cites W2000075444 @default.
• W1969434539 cites W2004906779 @default.
• W1969434539 cites W2006250857 @default.
• W1969434539 cites W2008019238 @default.
• W1969434539 cites W2023786646 @default.
• W1969434539 cites W2028562160 @default.
• W1969434539 cites W2029017865 @default.
• W1969434539 cites W2029148979 @default.
• W1969434539 cites W2030892371 @default.
• W1969434539 cites W2031740592 @default.
• W1969434539 cites W2032110442 @default.
• W1969434539 cites W2033771299 @default.
• W1969434539 cites W2038113509 @default.
• W1969434539 cites W2056181922 @default.
• W1969434539 cites W2059214757 @default.
• W1969434539 cites W2059305690 @default.
• W1969434539 cites W2065053969 @default.
• W1969434539 cites W2068042361 @default.
• W1969434539 cites W2070887142 @default.
• W1969434539 cites W2072286244 @default.
• W1969434539 cites W2074021811 @default.
• W1969434539 cites W2074117052 @default.
• W1969434539 cites W2078368771 @default.
• W1969434539 cites W2082344101 @default.
• W1969434539 cites W2090313884 @default.
• W1969434539 cites W2094822044 @default.
• W1969434539 cites W2100250883 @default.
• W1969434539 cites W2106274713 @default.
• W1969434539 cites W2108285073 @default.
• W1969434539 cites W2118749186 @default.
• W1969434539 cites W2122215582 @default.
• W1969434539 cites W2132810311 @default.
• W1969434539 cites W2150230606 @default.
• W1969434539 cites W2169152986 @default.
• W1969434539 cites W4253226932 @default.
• W1969434539 doi "https://doi.org/10.1016/j.neuropharm.2011.12.025" @default.
• W1969434539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22244942" @default.
• W1969434539 hasPublicationYear "2012" @default.
• W1969434539 type Work @default.
• W1969434539 sameAs 1969434539 @default.
• W1969434539 citedByCount "20" @default.
• W1969434539 countsByYear W19694345392012 @default.
• W1969434539 countsByYear W19694345392013 @default.
• W1969434539 countsByYear W19694345392014 @default.
• W1969434539 countsByYear W19694345392015 @default.
• W1969434539 countsByYear W19694345392016 @default.
• W1969434539 countsByYear W19694345392018 @default.
• W1969434539 countsByYear W19694345392019 @default.
• W1969434539 countsByYear W19694345392020 @default.
• W1969434539 countsByYear W19694345392021 @default.
• W1969434539 countsByYear W19694345392022 @default.
• W1969434539 countsByYear W19694345392023 @default.
• W1969434539 crossrefType "journal-article" @default.
• W1969434539 hasAuthorship W1969434539A5005503268 @default.
• W1969434539 hasAuthorship W1969434539A5042162742 @default.
• W1969434539 hasAuthorship W1969434539A5054899915 @default.
• W1969434539 hasAuthorship W1969434539A5059406139 @default.
• W1969434539 hasAuthorship W1969434539A5087738067 @default.
• W1969434539 hasAuthorship W1969434539A5088595764 @default.
• W1969434539 hasAuthorship W1969434539A5089278763 @default.
• W1969434539 hasConcept C126322002 @default.
• W1969434539 hasConcept C134018914 @default.
• W1969434539 hasConcept C177907266 @default.
• W1969434539 hasConcept C185592680 @default.
• W1969434539 hasConcept C25498285 @default.
• W1969434539 hasConcept C2776925932 @default.
• W1969434539 hasConcept C2779134260 @default.
• W1969434539 hasConcept C28406088 @default.
• W1969434539 hasConcept C31705614 @default.
• W1969434539 hasConcept C36103677 @default.
• W1969434539 hasConcept C41007966 @default.
• W1969434539 hasConcept C502032728 @default.
• W1969434539 hasConcept C55493867 @default.
• W1969434539 hasConcept C71924100 @default.
• W1969434539 hasConcept C79879829 @default.
• W1969434539 hasConcept C86803240 @default.
• W1969434539 hasConcept C95444343 @default.

• next