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- W1969440498 abstract "In experimental reports, blood flow redistribution occurred during CPB and vasoconstrictor administration restored perfusion pressure without improving splanchnic perfusion. We evaluated influence of vasoconstrictor administration during CPB from the viewpoint of the acid-base balance and the whole body oxygen metabolism. Twenty-one pediatric cases, which may be highly hemodiluted only to induce hypotension during CPB, of ventricular septal defect without blood transfusion except eventful cases were divided into two groups: whether vasoconstrictor was administered during CPB or not, and analyzed (n = 7 vs 15). Bypass flow, systemic perfusion pressure, and acid-base balance during CPB was maintained at around 2.4 ± 2.6 1/m2/min, higher than 30 mmHg by vasoconstrictor administration, and higher than −5.0 mEq/l in base excess by sodium bicarbonate administration. Body weight, CPB and aortic clump duration, blood temperature, bypass flow, perfusion pressure, and base excess level were comparable between two groups. However, more sodium bicarbonate was administered (5.23±1.22 vs 3.93±0.90 ml/kg, p <0.05) and duration from the operation to extubation was longer (3.9±1.5 vs 2.0±1.4 hrs, p <0.05) in the vasoconstrictor-administered group than in the control group, whereas blood lactate level on extubation and blood creatinine level on postoperative day 1 were comparable between the groups. In conclusion, vasoconstrictor administration during CPB temporarity deteriorates the acid-base balance and the whole body oxygen metabolism, which may make the complication worse induced by hypoperfusion arisen during CPB." @default.
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- W1969440498 date "2003-03-01" @default.
- W1969440498 modified "2023-10-18" @default.
- W1969440498 title "VASOCONSTRICTOR ADMINISTRATION DURING CARDIOPULMONARY BYPASS DETERIORATES THE WHOLE BODY OXYGEN METABOLISM" @default.
- W1969440498 doi "https://doi.org/10.1097/00002480-200303000-00037" @default.
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