Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969457480> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1969457480 endingPage "4734" @default.
- W1969457480 startingPage "4726" @default.
- W1969457480 abstract "This study employed morphometric analysis to evaluate changes in the histological characteristics that accompany relaxin-induced growth and softening of the vagina during the second half of rat pregnancy. There were three treatment groups (N = 4/group). Five milligrams of a monoclonal antibody for rat relaxin, designated MCA1, were injected iv daily on days 12–21 of gestation to treatment group MCA1. Control groups received either 5 mg of monoclonal antibody for fluorescein (MCAF; monoclonal antibody control) or 0.5 ml PBS (vehicle control). Vaginas were removed on day 22 of pregnancy, fixed in 10% neutral-buffered formalin, and embedded in paraffin. Tissue sections (5μ m) were stained with Gomori’s trichrome to visualize collagen, or orcein to visualize elastin. Measurements were performed with a light microscope equipped with a video camera connected to a computer. Within the vaginal stroma, the density of collagen fiber bundles was lower, the length of elastin fibers was shorter, and the cross-sectional area and wall thickness of arteries were greater in relaxin-replete control rats than in relaxin-deficient MCA1-treated rats. These relaxin-induced changes in the stroma appear to account, at least in part, for the hormone’s softening effect on the vagina. Within the epithelium, there were approximately 2-fold more basal and mucus-secreting cells in relaxin-replete control rats than in MCA1-treated rats. The relaxin-induced accumulation of epithelial cells appears to contribute to vaginal growth. We conclude that relaxin plays a role in preparing the vagina as well as the cervix for rapid and safe delivery in pregnant rats." @default.
- W1969457480 created "2016-06-24" @default.
- W1969457480 creator A5080507586 @default.
- W1969457480 creator A5087785384 @default.
- W1969457480 date "1998-11-01" @default.
- W1969457480 modified "2023-10-12" @default.
- W1969457480 title "Monoclonal Antibodies Specific for Rat Relaxin. X. Endogenous Relaxin Induces Changes in the Histological Characteristics of the Rat Vagina During the Second Half of Pregnancy" @default.
- W1969457480 cites W1587747486 @default.
- W1969457480 cites W1968127147 @default.
- W1969457480 cites W1969353470 @default.
- W1969457480 cites W1995265819 @default.
- W1969457480 cites W1997092643 @default.
- W1969457480 cites W2005857816 @default.
- W1969457480 cites W2027042375 @default.
- W1969457480 cites W2034756895 @default.
- W1969457480 cites W2038735628 @default.
- W1969457480 cites W2052332212 @default.
- W1969457480 cites W2058953115 @default.
- W1969457480 cites W2067981775 @default.
- W1969457480 cites W2069703218 @default.
- W1969457480 cites W2071979007 @default.
- W1969457480 cites W2075489858 @default.
- W1969457480 cites W2081480546 @default.
- W1969457480 cites W2085865284 @default.
- W1969457480 cites W2089160083 @default.
- W1969457480 cites W2097430813 @default.
- W1969457480 cites W2113279083 @default.
- W1969457480 cites W2118133612 @default.
- W1969457480 cites W2121568163 @default.
- W1969457480 cites W2144463402 @default.
- W1969457480 cites W2472443823 @default.
- W1969457480 doi "https://doi.org/10.1210/endo.139.11.6327" @default.
- W1969457480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9794485" @default.
- W1969457480 hasPublicationYear "1998" @default.
- W1969457480 type Work @default.
- W1969457480 sameAs 1969457480 @default.
- W1969457480 citedByCount "17" @default.
- W1969457480 countsByYear W19694574802013 @default.
- W1969457480 countsByYear W19694574802015 @default.
- W1969457480 countsByYear W19694574802016 @default.
- W1969457480 countsByYear W19694574802021 @default.
- W1969457480 crossrefType "journal-article" @default.
- W1969457480 hasAuthorship W1969457480A5080507586 @default.
- W1969457480 hasAuthorship W1969457480A5087785384 @default.
- W1969457480 hasBestOaLocation W19694574801 @default.
- W1969457480 hasConcept C105702510 @default.
- W1969457480 hasConcept C121608353 @default.
- W1969457480 hasConcept C126322002 @default.
- W1969457480 hasConcept C134018914 @default.
- W1969457480 hasConcept C204232928 @default.
- W1969457480 hasConcept C2777121736 @default.
- W1969457480 hasConcept C2777740455 @default.
- W1969457480 hasConcept C2777744392 @default.
- W1969457480 hasConcept C2779066055 @default.
- W1969457480 hasConcept C2779869378 @default.
- W1969457480 hasConcept C54355233 @default.
- W1969457480 hasConcept C70983919 @default.
- W1969457480 hasConcept C71315377 @default.
- W1969457480 hasConcept C71924100 @default.
- W1969457480 hasConcept C86803240 @default.
- W1969457480 hasConceptScore W1969457480C105702510 @default.
- W1969457480 hasConceptScore W1969457480C121608353 @default.
- W1969457480 hasConceptScore W1969457480C126322002 @default.
- W1969457480 hasConceptScore W1969457480C134018914 @default.
- W1969457480 hasConceptScore W1969457480C204232928 @default.
- W1969457480 hasConceptScore W1969457480C2777121736 @default.
- W1969457480 hasConceptScore W1969457480C2777740455 @default.
- W1969457480 hasConceptScore W1969457480C2777744392 @default.
- W1969457480 hasConceptScore W1969457480C2779066055 @default.
- W1969457480 hasConceptScore W1969457480C2779869378 @default.
- W1969457480 hasConceptScore W1969457480C54355233 @default.
- W1969457480 hasConceptScore W1969457480C70983919 @default.
- W1969457480 hasConceptScore W1969457480C71315377 @default.
- W1969457480 hasConceptScore W1969457480C71924100 @default.
- W1969457480 hasConceptScore W1969457480C86803240 @default.
- W1969457480 hasIssue "11" @default.
- W1969457480 hasLocation W19694574801 @default.
- W1969457480 hasLocation W19694574802 @default.
- W1969457480 hasOpenAccess W1969457480 @default.
- W1969457480 hasPrimaryLocation W19694574801 @default.
- W1969457480 hasRelatedWork W1409626837 @default.
- W1969457480 hasRelatedWork W1493861431 @default.
- W1969457480 hasRelatedWork W1585684155 @default.
- W1969457480 hasRelatedWork W2044783233 @default.
- W1969457480 hasRelatedWork W2047809519 @default.
- W1969457480 hasRelatedWork W207210111 @default.
- W1969457480 hasRelatedWork W2081195802 @default.
- W1969457480 hasRelatedWork W2403162604 @default.
- W1969457480 hasRelatedWork W2417427149 @default.
- W1969457480 hasRelatedWork W4238005745 @default.
- W1969457480 hasVolume "139" @default.
- W1969457480 isParatext "false" @default.
- W1969457480 isRetracted "false" @default.
- W1969457480 magId "1969457480" @default.
- W1969457480 workType "article" @default.