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- W1969468226 abstract "This study was designed to determine the cytoprotective activity of flavones of seabuckthorn (Hippophae rhamnoides L.) against tert-butyl hydroperoxide (tert-BOOH), used as an oxidant to induce oxidative damage, with lymphocytes as the model system. Addition of tert-BOOH (250 microM) to the cells resulted in enhanced cytotoxicity and free radical production. The intracellular calcium levels, caspase activity, and apoptosis were significantly increased following tert-BOOH treatment. Seabuckthorn flavones at the concentration of 100 microg/mL significantly inhibited tert-BOOH-induced cytotoxicity and free radical production and also restored the antioxidant status to that of control cells. Seabuckthorn flavones also significantly restricted tert-BOOH-induced apoptosis by decreasing intracellular calcium levels and caspase activity. The extract also decreased tert-BOOH-induced formation of DNA breaks by 30%. These observations suggest that the flavones of seabuckthorn have marked cytoprotective properties, which could be attributed to the antioxidant activity." @default.
- W1969468226 created "2016-06-24" @default.
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- W1969468226 date "2009-02-01" @default.
- W1969468226 modified "2023-10-14" @default.
- W1969468226 title "Cytoprotective and Antioxidant Activity of Seabuckthorn (<i>Hippophae rhamnoides</i> L.) Flavones Against <i>tert</i>-Butyl Hydroperoxide-Induced Cytotoxicity in Lymphocytes" @default.
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- W1969468226 doi "https://doi.org/10.1089/jmf.2007.0612" @default.
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