FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969479669> ?p ?o ?g. }

• W1969479669 endingPage "181" @default.
• W1969479669 startingPage "173" @default.
• W1969479669 abstract "SOX9 [(sex determining region Y)-box9] gene has been implicated in the development and progression of different neoplasms. This study investigated the role of Sox9 in the expression of TUBB3 gene, a marker of aggressiveness in ovarian cancer (OC), encoding βIII-tubulin protein. Gene expression was assessed by quantitative polymerase chain reaction (qPCR) in OC models. Using chromatin immunoprecipitation (ChIP) we found that Sox9 engages TUBB3 promoter at minus 980 base pairs from the transcriptional start site with transcriptional enhancing effects. Furthermore we found that Sox9 is a downstream target of Hif-2α, a transcription factor encoded by endothelial PAS domain protein-1 (EPAS1). Hypoxic microenvironment is a common feature of solid tumors associated with cancer aggressiveness. In the present work we found that knockdown of either SOX9 or EPAS1 abolished TUBB3 gene induction in hypoxia. This phenomenon was associated with a decrease in the number of cell colonies capable of growing in an anchorage-independent way. Using a nanofluidic genetic analyzer, the expression of SOX9, TUBB3 and EPAS1 was evaluated in 182 OC specimens. Double staining immunohistochemistry was employed to evaluate the expression and prognostic role of both Sox9 and βIII-tubulin. Results obtained in cellular models matched the pattern of clinical specimens. We documented a direct correlation among the expression of EPAS1, SOX9 and TUBB3 at mRNA level. Patients displaying no expression for the three genes had the best outcome. A poor prognosis significant in multivariate analysis was visible in patients featuring high expression of βIII-tubulin and nuclear Sox9. Sox9 allows the survival of OC cells upon hypoxic condition, through the activation of βIII-tubulin expression and its aberrant activation in OC is prominent in patients with aggressive OC." @default.
• W1969479669 created "2016-06-24" @default.
• W1969479669 creator A5014913208 @default.
• W1969479669 creator A5018348705 @default.
• W1969479669 creator A5018879946 @default.
• W1969479669 creator A5019808133 @default.
• W1969479669 creator A5020790343 @default.
• W1969479669 creator A5026048739 @default.
• W1969479669 creator A5044088727 @default.
• W1969479669 creator A5060417653 @default.
• W1969479669 creator A5060930954 @default.
• W1969479669 creator A5062743542 @default.
• W1969479669 creator A5073989957 @default.
• W1969479669 creator A5090583290 @default.
• W1969479669 date "2014-06-01" @default.
• W1969479669 modified "2023-10-04" @default.
• W1969479669 title "Sox9 and Hif-2α regulate TUBB3 gene expression and affect ovarian cancer aggressiveness" @default.
• W1969479669 cites W1970692048 @default.
• W1969479669 cites W1971898761 @default.
• W1969479669 cites W1989342147 @default.
• W1969479669 cites W1998748259 @default.
• W1969479669 cites W2009978277 @default.
• W1969479669 cites W2012162957 @default.
• W1969479669 cites W2023727725 @default.
• W1969479669 cites W2023952192 @default.
• W1969479669 cites W2025531664 @default.
• W1969479669 cites W2026601790 @default.
• W1969479669 cites W2038328856 @default.
• W1969479669 cites W2068720278 @default.
• W1969479669 cites W2070616156 @default.
• W1969479669 cites W2075711878 @default.
• W1969479669 cites W2081252249 @default.
• W1969479669 cites W2082444624 @default.
• W1969479669 cites W2084126321 @default.
• W1969479669 cites W2097607584 @default.
• W1969479669 cites W2105925116 @default.
• W1969479669 cites W2109658769 @default.
• W1969479669 cites W2114133947 @default.
• W1969479669 cites W2122544830 @default.
• W1969479669 cites W2123696077 @default.
• W1969479669 cites W2139450857 @default.
• W1969479669 cites W2169668454 @default.
• W1969479669 cites W2170289251 @default.
• W1969479669 cites W2170682201 @default.
• W1969479669 doi "https://doi.org/10.1016/j.gene.2014.03.037" @default.
• W1969479669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24661907" @default.
• W1969479669 hasPublicationYear "2014" @default.
• W1969479669 type Work @default.
• W1969479669 sameAs 1969479669 @default.
• W1969479669 citedByCount "61" @default.
• W1969479669 countsByYear W19694796692014 @default.
• W1969479669 countsByYear W19694796692015 @default.
• W1969479669 countsByYear W19694796692016 @default.
• W1969479669 countsByYear W19694796692017 @default.
• W1969479669 countsByYear W19694796692018 @default.
• W1969479669 countsByYear W19694796692019 @default.
• W1969479669 countsByYear W19694796692020 @default.
• W1969479669 countsByYear W19694796692021 @default.
• W1969479669 countsByYear W19694796692022 @default.
• W1969479669 countsByYear W19694796692023 @default.
• W1969479669 crossrefType "journal-article" @default.
• W1969479669 hasAuthorship W1969479669A5014913208 @default.
• W1969479669 hasAuthorship W1969479669A5018348705 @default.
• W1969479669 hasAuthorship W1969479669A5018879946 @default.
• W1969479669 hasAuthorship W1969479669A5019808133 @default.
• W1969479669 hasAuthorship W1969479669A5020790343 @default.
• W1969479669 hasAuthorship W1969479669A5026048739 @default.
• W1969479669 hasAuthorship W1969479669A5044088727 @default.
• W1969479669 hasAuthorship W1969479669A5060417653 @default.
• W1969479669 hasAuthorship W1969479669A5060930954 @default.
• W1969479669 hasAuthorship W1969479669A5062743542 @default.
• W1969479669 hasAuthorship W1969479669A5073989957 @default.
• W1969479669 hasAuthorship W1969479669A5090583290 @default.
• W1969479669 hasConcept C101762097 @default.
• W1969479669 hasConcept C104317684 @default.
• W1969479669 hasConcept C121608353 @default.
• W1969479669 hasConcept C134320426 @default.
• W1969479669 hasConcept C150194340 @default.
• W1969479669 hasConcept C153911025 @default.
• W1969479669 hasConcept C165864922 @default.
• W1969479669 hasConcept C173396325 @default.
• W1969479669 hasConcept C2778486617 @default.
• W1969479669 hasConcept C2780427987 @default.
• W1969479669 hasConcept C502942594 @default.
• W1969479669 hasConcept C54355233 @default.
• W1969479669 hasConcept C86339819 @default.
• W1969479669 hasConcept C86803240 @default.
• W1969479669 hasConceptScore W1969479669C101762097 @default.
• W1969479669 hasConceptScore W1969479669C104317684 @default.
• W1969479669 hasConceptScore W1969479669C121608353 @default.
• W1969479669 hasConceptScore W1969479669C134320426 @default.
• W1969479669 hasConceptScore W1969479669C150194340 @default.
• W1969479669 hasConceptScore W1969479669C153911025 @default.
• W1969479669 hasConceptScore W1969479669C165864922 @default.
• W1969479669 hasConceptScore W1969479669C173396325 @default.
• W1969479669 hasConceptScore W1969479669C2778486617 @default.
• W1969479669 hasConceptScore W1969479669C2780427987 @default.
• W1969479669 hasConceptScore W1969479669C502942594 @default.

• next