FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969481824> ?p ?o ?g. }

• W1969481824 endingPage "269" @default.
• W1969481824 startingPage "255" @default.
• W1969481824 abstract "Disruption of the genes encoding for the transcription coactivators, peroxisome proliferator-activated receptor (PPAR)-interacting protein (PRIP/ASC-2/RAP250/TRBP/NRC) and PPAR-binding protein (PBP/TRAP220/DRIP205/MED1), results in embryonic lethality by affecting placental and multiorgan development. Targeted deletion of coactivator PBP gene in liver parenchymal cells (PBP(LIV-/-)) results in the near abrogation of the induction of PPARalpha and CAR (constitutive androstane receptor)-regulated genes in liver. Here, we show that targeted deletion of coactivator PRIP gene in liver (PRIP(LIV-/-)) does not affect the induction of PPARalpha-regulated pleiotropic responses, including hepatomegaly, hepatic peroxisome proliferation, and induction of mRNAs of genes involved in fatty acid oxidation system, indicating that PRIP is not essential for PPARalpha-mediated transcriptional activity. We also provide additional data to show that liver-specific deletion of PRIP gene does not interfere with the induction of genes regulated by nuclear receptor CAR. Furthermore, disruption of PRIP gene in liver did not alter zoxazolamine-induced paralysis, and acetaminophen-induced hepatotoxicity. Studies with adenovirally driven EGFP-CAR expression in liver demonstrated that, unlike PBP, the absence of PRIP does not prevent phenobarbital-mediated nuclear translocation/retention of the receptor CAR in liver in vivo and cultured hepatocytes in vitro. These results show that PRIP deficiency in liver does not interfere with the function of nuclear receptors PPARalpha and CAR. The dependence of PPARalpha- and CAR-regulated gene transcription on coactivator PBP but not on PRIP attests to the existence of coactivator selectivity in nuclear receptor function." @default.
• W1969481824 created "2016-06-24" @default.
• W1969481824 creator A5009369325 @default.
• W1969481824 creator A5034025152 @default.
• W1969481824 creator A5034754078 @default.
• W1969481824 creator A5057095504 @default.
• W1969481824 creator A5061442073 @default.
• W1969481824 creator A5064692183 @default.
• W1969481824 creator A5067664888 @default.
• W1969481824 creator A5074228062 @default.
• W1969481824 creator A5089191106 @default.
• W1969481824 date "2006-04-01" @default.
• W1969481824 modified "2023-10-13" @default.
• W1969481824 title "Transcription Coactivator PRIP, the Peroxisome Proliferator-Activated Receptor (PPAR)-Interacting Protein, Is Redundant for the Function of Nuclear Receptors PPARα and CAR, the Constitutive Androstane Receptor, in Mouse Liver" @default.
• W1969481824 cites W1485938486 @default.
• W1969481824 cites W1516032052 @default.
• W1969481824 cites W1564796335 @default.
• W1969481824 cites W1593089530 @default.
• W1969481824 cites W1964731473 @default.
• W1969481824 cites W1968867681 @default.
• W1969481824 cites W1970569586 @default.
• W1969481824 cites W1973358445 @default.
• W1969481824 cites W1979761686 @default.
• W1969481824 cites W1982056201 @default.
• W1969481824 cites W1985338761 @default.
• W1969481824 cites W1986050686 @default.
• W1969481824 cites W1989017301 @default.
• W1969481824 cites W1990529844 @default.
• W1969481824 cites W1996334614 @default.
• W1969481824 cites W1997868107 @default.
• W1969481824 cites W2000950973 @default.
• W1969481824 cites W2004784202 @default.
• W1969481824 cites W2006074160 @default.
• W1969481824 cites W2008467936 @default.
• W1969481824 cites W2008557193 @default.
• W1969481824 cites W2008698762 @default.
• W1969481824 cites W2012155675 @default.
• W1969481824 cites W2017130430 @default.
• W1969481824 cites W2020852287 @default.
• W1969481824 cites W2040567225 @default.
• W1969481824 cites W2041390597 @default.
• W1969481824 cites W2041393798 @default.
• W1969481824 cites W2042683090 @default.
• W1969481824 cites W2051988120 @default.
• W1969481824 cites W2052532538 @default.
• W1969481824 cites W2052746699 @default.
• W1969481824 cites W2054121324 @default.
• W1969481824 cites W2061619516 @default.
• W1969481824 cites W2063312342 @default.
• W1969481824 cites W2064956340 @default.
• W1969481824 cites W2066092624 @default.
• W1969481824 cites W2068113812 @default.
• W1969481824 cites W2068331430 @default.
• W1969481824 cites W2069303019 @default.
• W1969481824 cites W2076477323 @default.
• W1969481824 cites W2076750433 @default.
• W1969481824 cites W2078684758 @default.
• W1969481824 cites W2079688329 @default.
• W1969481824 cites W2080301714 @default.
• W1969481824 cites W2081532782 @default.
• W1969481824 cites W2085792867 @default.
• W1969481824 cites W2095422595 @default.
• W1969481824 cites W2106208437 @default.
• W1969481824 cites W2111254493 @default.
• W1969481824 cites W2121914083 @default.
• W1969481824 cites W2128157627 @default.
• W1969481824 cites W2128266687 @default.
• W1969481824 cites W2128858627 @default.
• W1969481824 cites W2136359444 @default.
• W1969481824 cites W2136630049 @default.
• W1969481824 cites W2143241514 @default.
• W1969481824 cites W2143462761 @default.
• W1969481824 cites W2148083393 @default.
• W1969481824 cites W2148590099 @default.
• W1969481824 cites W2156281856 @default.
• W1969481824 cites W2156575042 @default.
• W1969481824 cites W2158268923 @default.
• W1969481824 cites W2158673140 @default.
• W1969481824 cites W2166279203 @default.
• W1969481824 cites W2167985579 @default.
• W1969481824 cites W2168661333 @default.
• W1969481824 cites W2170099831 @default.
• W1969481824 cites W2172032447 @default.
• W1969481824 doi "https://doi.org/10.3727/000000006780666948" @default.
• W1969481824 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6032459" @default.
• W1969481824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17605299" @default.
• W1969481824 hasPublicationYear "2006" @default.
• W1969481824 type Work @default.
• W1969481824 sameAs 1969481824 @default.
• W1969481824 citedByCount "11" @default.
• W1969481824 countsByYear W19694818242015 @default.
• W1969481824 countsByYear W19694818242020 @default.
• W1969481824 countsByYear W19694818242022 @default.
• W1969481824 crossrefType "journal-article" @default.
• W1969481824 hasAuthorship W1969481824A5009369325 @default.
• W1969481824 hasAuthorship W1969481824A5034025152 @default.
• W1969481824 hasAuthorship W1969481824A5034754078 @default.
• W1969481824 hasAuthorship W1969481824A5057095504 @default.

• next