Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969486561> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1969486561 endingPage "299" @default.
- W1969486561 startingPage "295" @default.
- W1969486561 abstract "The enzyme-catalysed conjugation of (+/-)-7 beta,8 alpha-dihydroxy-9 alpha, 10 alpha-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(+/-)-anti-BPDE] with glutathione (GSH) by cytosolic GSH transferases isolated primarily from rat lung has been studied. GSH transferase 4-4 was active in the GSH conjugation of anti-BPDE, whereas transferases 2-2 and 3-3 showed little activity. GSH transferase 1-1 did not contribute to the activity since significant amounts were not detected in the rat lung. Activity was also obtained with several acidic pulmonary GSH transferases and with a newly described form, transferase 7-7, also isolated from rat kidney and from hyperplastic liver nodules. The catalytic efficiency (kcat/Km) of transferase 7-7 was seven times that of transferase 4-4, the most active rat transferase previously identified. When the GSH concentration was varied at constant (+/-)-anti-BPDE concentration in the presence of transferases 4-4, 7-7 or the major acidic transferase, non-linear Lineweaver-Burk plots were obtained. Resolution of the GSH conjugates of the two enantiomers of (+/-)-anti-BPDE by h.p.l.c. showed that all isoenzymes with notable activity were selective (greater than or equal to 97%) for the (+)-enantiomer of anti-BPDE, which is generally considered to be the most carcinogenic form of BPDE. The possibility that one enantiomer inhibits the conjugation of the other enantiomer with GSH cannot be excluded and may quantitatively affect the results obtained." @default.
- W1969486561 created "2016-06-24" @default.
- W1969486561 creator A5015070775 @default.
- W1969486561 creator A5020826583 @default.
- W1969486561 creator A5058008284 @default.
- W1969486561 creator A5080145082 @default.
- W1969486561 date "1986-01-01" @default.
- W1969486561 modified "2023-10-02" @default.
- W1969486561 title "Glutathione transferases in rat lung: the presence of transferase 7-7, highly efficient in the conjugation of glutathione with the carcinogenic (+)-7β,8α-dihydroxy-9α,10α-oxy-7,8,9,10-tetrahydrobenzo[a]pyrene" @default.
- W1969486561 doi "https://doi.org/10.1093/carcin/7.2.295" @default.
- W1969486561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3081272" @default.
- W1969486561 hasPublicationYear "1986" @default.
- W1969486561 type Work @default.
- W1969486561 sameAs 1969486561 @default.
- W1969486561 citedByCount "115" @default.
- W1969486561 countsByYear W19694865612016 @default.
- W1969486561 countsByYear W19694865612018 @default.
- W1969486561 countsByYear W19694865612019 @default.
- W1969486561 crossrefType "journal-article" @default.
- W1969486561 hasAuthorship W1969486561A5015070775 @default.
- W1969486561 hasAuthorship W1969486561A5020826583 @default.
- W1969486561 hasAuthorship W1969486561A5058008284 @default.
- W1969486561 hasAuthorship W1969486561A5080145082 @default.
- W1969486561 hasConcept C114246631 @default.
- W1969486561 hasConcept C119795356 @default.
- W1969486561 hasConcept C178790620 @default.
- W1969486561 hasConcept C181199279 @default.
- W1969486561 hasConcept C185592680 @default.
- W1969486561 hasConcept C2776376580 @default.
- W1969486561 hasConcept C2776907368 @default.
- W1969486561 hasConcept C2777538855 @default.
- W1969486561 hasConcept C2778951431 @default.
- W1969486561 hasConcept C486523 @default.
- W1969486561 hasConcept C538909803 @default.
- W1969486561 hasConcept C55493867 @default.
- W1969486561 hasConcept C71240020 @default.
- W1969486561 hasConcept C98539663 @default.
- W1969486561 hasConceptScore W1969486561C114246631 @default.
- W1969486561 hasConceptScore W1969486561C119795356 @default.
- W1969486561 hasConceptScore W1969486561C178790620 @default.
- W1969486561 hasConceptScore W1969486561C181199279 @default.
- W1969486561 hasConceptScore W1969486561C185592680 @default.
- W1969486561 hasConceptScore W1969486561C2776376580 @default.
- W1969486561 hasConceptScore W1969486561C2776907368 @default.
- W1969486561 hasConceptScore W1969486561C2777538855 @default.
- W1969486561 hasConceptScore W1969486561C2778951431 @default.
- W1969486561 hasConceptScore W1969486561C486523 @default.
- W1969486561 hasConceptScore W1969486561C538909803 @default.
- W1969486561 hasConceptScore W1969486561C55493867 @default.
- W1969486561 hasConceptScore W1969486561C71240020 @default.
- W1969486561 hasConceptScore W1969486561C98539663 @default.
- W1969486561 hasIssue "2" @default.
- W1969486561 hasLocation W19694865611 @default.
- W1969486561 hasLocation W19694865612 @default.
- W1969486561 hasOpenAccess W1969486561 @default.
- W1969486561 hasPrimaryLocation W19694865611 @default.
- W1969486561 hasRelatedWork W1557283430 @default.
- W1969486561 hasRelatedWork W1964278933 @default.
- W1969486561 hasRelatedWork W1967940207 @default.
- W1969486561 hasRelatedWork W1969486561 @default.
- W1969486561 hasRelatedWork W2033669891 @default.
- W1969486561 hasRelatedWork W2071045338 @default.
- W1969486561 hasRelatedWork W2122310987 @default.
- W1969486561 hasRelatedWork W2138971261 @default.
- W1969486561 hasRelatedWork W2216858432 @default.
- W1969486561 hasRelatedWork W2596178396 @default.
- W1969486561 hasVolume "7" @default.
- W1969486561 isParatext "false" @default.
- W1969486561 isRetracted "false" @default.
- W1969486561 magId "1969486561" @default.
- W1969486561 workType "article" @default.