Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969488373> ?p ?o ?g. }
- W1969488373 endingPage "58" @default.
- W1969488373 startingPage "52" @default.
- W1969488373 abstract "Statin drugs lower blood cholesterol by inhibiting hepatic 3-hydroxy-3-methylglutaryl-Coenzyme-A reductase. Statins are known to inhibit sterol production in the testis, but effect of statins on testosterone production has not been studied critically in vitro and clinical data are controversial. We measured 18-h testosterone production in vitro, using highly purified rat Leydig cells exposed to atorvastatin, mevastatin, or simvastatin and also determined if statin-induced inhibition of testosterone production could be bypassed with substrate distal to cholesterol. Statins had no effect on testosterone production during culture without LH. However, with 10 ng/mL LH, testosterone production was ≥12-fold higher and markedly inhibited (−40%) by ≥0.3 μM statin. Leydig cells provided sub-saturating pregnenolone or progesterone to bypass the site of statin action, maintained LH-stimulated testosterone production at or above amounts observed with LH stimulation and no statin. Pregnenolone resulted in greater testosterone production, but LH responsiveness was lost. With progesterone, LH responsiveness was maintained." @default.
- W1969488373 created "2016-06-24" @default.
- W1969488373 creator A5033267507 @default.
- W1969488373 creator A5076214475 @default.
- W1969488373 creator A5076792250 @default.
- W1969488373 date "2014-06-01" @default.
- W1969488373 modified "2023-10-18" @default.
- W1969488373 title "Statin drugs markedly inhibit testosterone production by rat Leydig cells in vitro: Implications for men" @default.
- W1969488373 cites W15621339 @default.
- W1969488373 cites W1606937999 @default.
- W1969488373 cites W1735246829 @default.
- W1969488373 cites W1963827257 @default.
- W1969488373 cites W1963829759 @default.
- W1969488373 cites W1973002810 @default.
- W1969488373 cites W1974079370 @default.
- W1969488373 cites W1977644047 @default.
- W1969488373 cites W1987970818 @default.
- W1969488373 cites W1993257987 @default.
- W1969488373 cites W2001302689 @default.
- W1969488373 cites W2001644952 @default.
- W1969488373 cites W2002604697 @default.
- W1969488373 cites W2005169645 @default.
- W1969488373 cites W2018126221 @default.
- W1969488373 cites W2021591445 @default.
- W1969488373 cites W2029708361 @default.
- W1969488373 cites W2032022098 @default.
- W1969488373 cites W2035645373 @default.
- W1969488373 cites W2036200642 @default.
- W1969488373 cites W2038338711 @default.
- W1969488373 cites W2051191691 @default.
- W1969488373 cites W2053770173 @default.
- W1969488373 cites W2055561625 @default.
- W1969488373 cites W2061236466 @default.
- W1969488373 cites W2074595309 @default.
- W1969488373 cites W2078603028 @default.
- W1969488373 cites W2079036148 @default.
- W1969488373 cites W2097176143 @default.
- W1969488373 cites W2105232034 @default.
- W1969488373 cites W2114728551 @default.
- W1969488373 cites W2121951682 @default.
- W1969488373 cites W2125149319 @default.
- W1969488373 cites W2126846194 @default.
- W1969488373 cites W2129643529 @default.
- W1969488373 cites W2138624097 @default.
- W1969488373 cites W2139893960 @default.
- W1969488373 cites W2142162377 @default.
- W1969488373 cites W2148463229 @default.
- W1969488373 cites W2152740187 @default.
- W1969488373 cites W2155228880 @default.
- W1969488373 cites W2169025780 @default.
- W1969488373 cites W2183663567 @default.
- W1969488373 cites W2232111705 @default.
- W1969488373 cites W2253047109 @default.
- W1969488373 cites W4210994334 @default.
- W1969488373 cites W86393565 @default.
- W1969488373 doi "https://doi.org/10.1016/j.reprotox.2013.12.010" @default.
- W1969488373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24462564" @default.
- W1969488373 hasPublicationYear "2014" @default.
- W1969488373 type Work @default.
- W1969488373 sameAs 1969488373 @default.
- W1969488373 citedByCount "28" @default.
- W1969488373 countsByYear W19694883732014 @default.
- W1969488373 countsByYear W19694883732015 @default.
- W1969488373 countsByYear W19694883732016 @default.
- W1969488373 countsByYear W19694883732017 @default.
- W1969488373 countsByYear W19694883732018 @default.
- W1969488373 countsByYear W19694883732019 @default.
- W1969488373 countsByYear W19694883732020 @default.
- W1969488373 countsByYear W19694883732021 @default.
- W1969488373 countsByYear W19694883732022 @default.
- W1969488373 countsByYear W19694883732023 @default.
- W1969488373 crossrefType "journal-article" @default.
- W1969488373 hasAuthorship W1969488373A5033267507 @default.
- W1969488373 hasAuthorship W1969488373A5076214475 @default.
- W1969488373 hasAuthorship W1969488373A5076792250 @default.
- W1969488373 hasConcept C104950815 @default.
- W1969488373 hasConcept C121608353 @default.
- W1969488373 hasConcept C126322002 @default.
- W1969488373 hasConcept C134018914 @default.
- W1969488373 hasConcept C134651460 @default.
- W1969488373 hasConcept C181199279 @default.
- W1969488373 hasConcept C185592680 @default.
- W1969488373 hasConcept C202751555 @default.
- W1969488373 hasConcept C24998067 @default.
- W1969488373 hasConcept C2775976807 @default.
- W1969488373 hasConcept C2776166826 @default.
- W1969488373 hasConcept C2776329913 @default.
- W1969488373 hasConcept C2776839432 @default.
- W1969488373 hasConcept C2777482532 @default.
- W1969488373 hasConcept C2777736315 @default.
- W1969488373 hasConcept C2778163477 @default.
- W1969488373 hasConcept C2778575703 @default.
- W1969488373 hasConcept C2779279991 @default.
- W1969488373 hasConcept C2780193516 @default.
- W1969488373 hasConcept C2780902042 @default.
- W1969488373 hasConcept C2780940807 @default.
- W1969488373 hasConcept C526171541 @default.
- W1969488373 hasConcept C530470458 @default.