Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969492071> ?p ?o ?g. }
- W1969492071 endingPage "231" @default.
- W1969492071 startingPage "225" @default.
- W1969492071 abstract "Cadmium, a well-known toxic heavy metal, affects cellular physiology by disturbing cellular signaling pathways. We investigate the effect of cadmium on cellular differentiation using 3T3-L1 preadipocyte cell lines as an in vitro model. Here, it was shown that cadmium (3 μM) significantly decreased both glycerol-3-phosphate dehydrogenase (GPDH) activity and lipid accumulation of differentiating 3T3-L1 cells in a dose-dependent manner. In addition, inhibitory action of cadmium on differentiating 3T3-L1 cells was effective only at the initial stage of 3T3-L1 preadipocyte differentiation. Western blot analysis revealed that cadmium suppressed the expression of CCAAT/enhancer-binding protein alpha (C/EBPα) and peroxisome proliferator-activator receptor gamma (PPARγ) proteins, key transcriptional activators for adipogenesis, in a dose-dependent manner. These results suggest that the inhibitory effects of cadmium on 3T3-L1 preadipocyte differentiation, as indicated by a decrease in GPDH activity and lipid accumulation, a marker of adipogenesis, appeared to be mediated through the downregulated expression of C/EBPα and PPARγ proteins." @default.
- W1969492071 created "2016-06-24" @default.
- W1969492071 creator A5015301175 @default.
- W1969492071 creator A5023299388 @default.
- W1969492071 creator A5063037605 @default.
- W1969492071 date "2011-08-18" @default.
- W1969492071 modified "2023-09-25" @default.
- W1969492071 title "Cadmium inhibits the differentiation of 3T3-L1 preadipocyte through the C/EBPα and PPARγ pathways" @default.
- W1969492071 cites W110026566 @default.
- W1969492071 cites W1595843384 @default.
- W1969492071 cites W1815087127 @default.
- W1969492071 cites W1858494250 @default.
- W1969492071 cites W1907219612 @default.
- W1969492071 cites W1967149229 @default.
- W1969492071 cites W1970658270 @default.
- W1969492071 cites W1974991454 @default.
- W1969492071 cites W1977252673 @default.
- W1969492071 cites W1981119542 @default.
- W1969492071 cites W1982406683 @default.
- W1969492071 cites W2002519246 @default.
- W1969492071 cites W2003237280 @default.
- W1969492071 cites W2006342727 @default.
- W1969492071 cites W2007431652 @default.
- W1969492071 cites W2007799082 @default.
- W1969492071 cites W2020393862 @default.
- W1969492071 cites W2021725944 @default.
- W1969492071 cites W2042618169 @default.
- W1969492071 cites W2056398608 @default.
- W1969492071 cites W2065835272 @default.
- W1969492071 cites W2069348023 @default.
- W1969492071 cites W2071692398 @default.
- W1969492071 cites W2072508481 @default.
- W1969492071 cites W2077065305 @default.
- W1969492071 cites W2077701145 @default.
- W1969492071 cites W2082358051 @default.
- W1969492071 cites W2088587975 @default.
- W1969492071 cites W2096390421 @default.
- W1969492071 cites W2102313291 @default.
- W1969492071 cites W2108675610 @default.
- W1969492071 cites W2130030488 @default.
- W1969492071 cites W2135203759 @default.
- W1969492071 cites W2140890698 @default.
- W1969492071 cites W2153081895 @default.
- W1969492071 cites W2160873790 @default.
- W1969492071 cites W2176176727 @default.
- W1969492071 cites W2276776369 @default.
- W1969492071 doi "https://doi.org/10.3109/01480545.2011.591401" @default.
- W1969492071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21848503" @default.
- W1969492071 hasPublicationYear "2011" @default.
- W1969492071 type Work @default.
- W1969492071 sameAs 1969492071 @default.
- W1969492071 citedByCount "25" @default.
- W1969492071 countsByYear W19694920712013 @default.
- W1969492071 countsByYear W19694920712015 @default.
- W1969492071 countsByYear W19694920712016 @default.
- W1969492071 countsByYear W19694920712017 @default.
- W1969492071 countsByYear W19694920712018 @default.
- W1969492071 countsByYear W19694920712019 @default.
- W1969492071 countsByYear W19694920712020 @default.
- W1969492071 countsByYear W19694920712021 @default.
- W1969492071 countsByYear W19694920712022 @default.
- W1969492071 countsByYear W19694920712023 @default.
- W1969492071 crossrefType "journal-article" @default.
- W1969492071 hasAuthorship W1969492071A5015301175 @default.
- W1969492071 hasAuthorship W1969492071A5023299388 @default.
- W1969492071 hasAuthorship W1969492071A5063037605 @default.
- W1969492071 hasConcept C104317684 @default.
- W1969492071 hasConcept C122927707 @default.
- W1969492071 hasConcept C142536801 @default.
- W1969492071 hasConcept C148738053 @default.
- W1969492071 hasConcept C170493617 @default.
- W1969492071 hasConcept C185592680 @default.
- W1969492071 hasConcept C187345961 @default.
- W1969492071 hasConcept C198826908 @default.
- W1969492071 hasConcept C25095133 @default.
- W1969492071 hasConcept C2776746612 @default.
- W1969492071 hasConcept C54009773 @default.
- W1969492071 hasConcept C55493867 @default.
- W1969492071 hasConcept C86803240 @default.
- W1969492071 hasConcept C88045685 @default.
- W1969492071 hasConcept C95444343 @default.
- W1969492071 hasConceptScore W1969492071C104317684 @default.
- W1969492071 hasConceptScore W1969492071C122927707 @default.
- W1969492071 hasConceptScore W1969492071C142536801 @default.
- W1969492071 hasConceptScore W1969492071C148738053 @default.
- W1969492071 hasConceptScore W1969492071C170493617 @default.
- W1969492071 hasConceptScore W1969492071C185592680 @default.
- W1969492071 hasConceptScore W1969492071C187345961 @default.
- W1969492071 hasConceptScore W1969492071C198826908 @default.
- W1969492071 hasConceptScore W1969492071C25095133 @default.
- W1969492071 hasConceptScore W1969492071C2776746612 @default.
- W1969492071 hasConceptScore W1969492071C54009773 @default.
- W1969492071 hasConceptScore W1969492071C55493867 @default.
- W1969492071 hasConceptScore W1969492071C86803240 @default.
- W1969492071 hasConceptScore W1969492071C88045685 @default.
- W1969492071 hasConceptScore W1969492071C95444343 @default.
- W1969492071 hasIssue "2" @default.
- W1969492071 hasLocation W19694920711 @default.