FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969500024> ?p ?o ?g. }

• W1969500024 endingPage "150" @default.
• W1969500024 startingPage "142" @default.
• W1969500024 abstract "Objective: To determine whether burn-induced peroxynitrite production and expression of lung inducible nitric oxide synthase (iNOS), intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule (VCAM)-1, CXCR2, macrophage inflammatory protein (MIP)-2, and neutrophil chemokine (KC) are mediated by the c-Jun NH2-terminal kinase (JNK). Design: Prospective, experimental study. Setting: Research laboratory at a university hospital. Subjects: Thermal injury models in the mice. Interventions: In experiment 1, specific pathogen-free C57/BL6 mice were subjected to 30% total body surface area third-degree burn over shaved back. At 0 hr, 2 hrs, 4 hrs, and 6 hrs after burn, lung tissues of those mice were harvested for JNK activity assay, AP-1 DNA-binding activity, and pJNK immunohistochemistry. In experiment 2, a specific JNK inhibitor, SP600125, was given (30 mg/kg intraperitoneally) to mice immediately postburn to suppress the JNK activity. At 8 hrs after burn, blood was assayed for the peroxynitrite-mediated dihydrorhodamine (DHR) 123 oxidation. Lung tissues were harvested for myeloperoxidase (MPO) determination, ICAM-1, VCAM-1, CXCR2, KC, MIP-2, interleukin-1β, and interleukin-6 messenger RNA expression; iNOS immunohistochemical staining; and histologic studies. Pulmonary microvascular dysfunction was quantified by measuring the extravasations of Evans blue dye. Measurements and Main Results: The JNK activity and AP-1 DNA-binding activity of lung tissue significantly increased to a peak at 2 hrs and 4 hrs, respectively, after thermal injury. Immunohistochemical study demonstrated that the increase of the pJNK was mostly from the bronchiole epithelial cells. This increase of MPO activity in lung, blood DHR 123 oxidation level, and lung permeability increased six-fold, nine-fold, and four-fold after burn. SP600125 administration obliterated the thermal injury-induced JNK activity, AP-1 DNA-binding activity, and iNOS expression in lung tissue. SP600125 treatment also significantly decreased MPO activity, blood DHR 123 oxidation, and lung permeability by 54%, 8%, and 47%, respectively, and markedly decreased the thermal injury-induced perivascular and interstitial inflammatory cell infiltration and septum edema. Furthermore, SP600125 abolished thermal injury-induced ICAM-1, VCAM-1, CXCR2, MIP-2, and KC but not interleukin-1β and interleukin-6 messenger RNA levels of lung tissues. Conclusions: Thermal injury induces lung tissue JNK activation and AP-1 DNA-binding activity mainly from airway epithelial cells. Thermal injury-induced peroxynitrite production and lung iNOS, ICAM-1, and VCAM-1 expression are mediated by the JNK signaling. JNK inhibition decreases thermal injury-induced lung neutrophil infiltration and subsequently pulmonary hyperpermeability." @default.
• W1969500024 created "2016-06-24" @default.
• W1969500024 creator A5018778485 @default.
• W1969500024 creator A5042858280 @default.
• W1969500024 creator A5047341327 @default.
• W1969500024 creator A5051421168 @default.
• W1969500024 date "2006-01-01" @default.
• W1969500024 modified "2023-10-02" @default.
• W1969500024 title "Thermal injury-induced peroxynitrite production and pulmonary inducible nitric oxide synthase expression depend on JNK/AP-1 signaling" @default.
• W1969500024 cites W1593402425 @default.
• W1969500024 cites W1963659073 @default.
• W1969500024 cites W1981062532 @default.
• W1969500024 cites W1985756708 @default.
• W1969500024 cites W1991068091 @default.
• W1969500024 cites W1994006450 @default.
• W1969500024 cites W2005211250 @default.
• W1969500024 cites W2009880876 @default.
• W1969500024 cites W2028898179 @default.
• W1969500024 cites W2039912462 @default.
• W1969500024 cites W2043006994 @default.
• W1969500024 cites W2065767221 @default.
• W1969500024 cites W2068315715 @default.
• W1969500024 cites W2070044720 @default.
• W1969500024 cites W2079879922 @default.
• W1969500024 cites W2082194437 @default.
• W1969500024 cites W2086898975 @default.
• W1969500024 cites W2087586960 @default.
• W1969500024 cites W2092721077 @default.
• W1969500024 cites W2096931514 @default.
• W1969500024 cites W2102701779 @default.
• W1969500024 cites W2111300036 @default.
• W1969500024 cites W2112686176 @default.
• W1969500024 cites W2118396663 @default.
• W1969500024 cites W2133454381 @default.
• W1969500024 cites W2138534348 @default.
• W1969500024 cites W2139319526 @default.
• W1969500024 cites W2150467353 @default.
• W1969500024 cites W2171407498 @default.
• W1969500024 cites W2326425498 @default.
• W1969500024 cites W2410320275 @default.
• W1969500024 cites W2415420446 @default.
• W1969500024 doi "https://doi.org/10.1097/01.ccm.0000190621.48720.8c" @default.
• W1969500024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16374168" @default.
• W1969500024 hasPublicationYear "2006" @default.
• W1969500024 type Work @default.
• W1969500024 sameAs 1969500024 @default.
• W1969500024 citedByCount "19" @default.
• W1969500024 countsByYear W19695000242012 @default.
• W1969500024 countsByYear W19695000242013 @default.
• W1969500024 countsByYear W19695000242016 @default.
• W1969500024 countsByYear W19695000242018 @default.
• W1969500024 countsByYear W19695000242021 @default.
• W1969500024 crossrefType "journal-article" @default.
• W1969500024 hasAuthorship W1969500024A5018778485 @default.
• W1969500024 hasAuthorship W1969500024A5042858280 @default.
• W1969500024 hasAuthorship W1969500024A5047341327 @default.
• W1969500024 hasAuthorship W1969500024A5051421168 @default.
• W1969500024 hasConcept C126322002 @default.
• W1969500024 hasConcept C13373296 @default.
• W1969500024 hasConcept C153911025 @default.
• W1969500024 hasConcept C181199279 @default.
• W1969500024 hasConcept C185592680 @default.
• W1969500024 hasConcept C203014093 @default.
• W1969500024 hasConcept C203565725 @default.
• W1969500024 hasConcept C2776914184 @default.
• W1969500024 hasConcept C2777622882 @default.
• W1969500024 hasConcept C2778784160 @default.
• W1969500024 hasConcept C2780795997 @default.
• W1969500024 hasConcept C519581460 @default.
• W1969500024 hasConcept C55493867 @default.
• W1969500024 hasConcept C71924100 @default.
• W1969500024 hasConcept C86803240 @default.
• W1969500024 hasConcept C98274493 @default.
• W1969500024 hasConceptScore W1969500024C126322002 @default.
• W1969500024 hasConceptScore W1969500024C13373296 @default.
• W1969500024 hasConceptScore W1969500024C153911025 @default.
• W1969500024 hasConceptScore W1969500024C181199279 @default.
• W1969500024 hasConceptScore W1969500024C185592680 @default.
• W1969500024 hasConceptScore W1969500024C203014093 @default.
• W1969500024 hasConceptScore W1969500024C203565725 @default.
• W1969500024 hasConceptScore W1969500024C2776914184 @default.
• W1969500024 hasConceptScore W1969500024C2777622882 @default.
• W1969500024 hasConceptScore W1969500024C2778784160 @default.
• W1969500024 hasConceptScore W1969500024C2780795997 @default.
• W1969500024 hasConceptScore W1969500024C519581460 @default.
• W1969500024 hasConceptScore W1969500024C55493867 @default.
• W1969500024 hasConceptScore W1969500024C71924100 @default.
• W1969500024 hasConceptScore W1969500024C86803240 @default.
• W1969500024 hasConceptScore W1969500024C98274493 @default.
• W1969500024 hasIssue "1" @default.
• W1969500024 hasLocation W19695000241 @default.
• W1969500024 hasLocation W19695000242 @default.
• W1969500024 hasOpenAccess W1969500024 @default.
• W1969500024 hasPrimaryLocation W19695000241 @default.
• W1969500024 hasRelatedWork W1992148861 @default.
• W1969500024 hasRelatedWork W2004287136 @default.
• W1969500024 hasRelatedWork W2017703364 @default.
• W1969500024 hasRelatedWork W2024138274 @default.

• next