FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969504080> ?p ?o ?g. }

• W1969504080 endingPage "2322" @default.
• W1969504080 startingPage "2313" @default.
• W1969504080 abstract "Objective: Perforin and granzyme are cytotoxic effector molecules that are believed to play essential roles in cytotoxic T cell (CTL) activity. We tested the hypothesis that dysregulation of these effector molecules contributes to defects of CD8 antiviral immune responses in pediatric subjects in chronic stages of perinatal HIV infection. Design/Method: Studies of CD8 T cells were conducted in 33 treatment experienced HIV+ patients (median age, 10.6 years) and in 14 age-matched healthy controls. CD8 T cells specific for HIV Gag and Pol peptides were identified in HLA-A2+ patients by tetramer binding assays. HIV-specific and total CD8 T cells were examined for perforin, granzyme and expression of CD27, a marker that is lost in terminally differentiated cells. Results: Three populations of CD8 T cells were identified: granzyme+ perforin+; granzyme+ perforin− and cells negative for both perforin and granzyme. In HIV infected patients, granzyme+ cells were increased in total CD8 T cells (39% versus 13% in controls) and were highest in HIV Gag-specific CD8 cells (42%). Perforin+ CD8 T cells were approximately fivefold fewer than granzyme+ CD8 T cells and were enriched in CD27 negative cells. Most HIV-specific CD8 cells were CD27+. Granzyme expression in CD8 T cells correlated negatively with CD4 percentage and positively with virus load. Conclusion: A disproportionate and generalized increase in CD27+, granzyme+, CD8 T cells is a hallmark of established pediatric HIV infection. These findings support the concept of skewed maturation, with failure of CD8 T cells to mature into perforin-enriched, CD27-negative, effector cells." @default.
• W1969504080 created "2016-06-24" @default.
• W1969504080 creator A5002278563 @default.
• W1969504080 creator A5048785797 @default.
• W1969504080 creator A5067199049 @default.
• W1969504080 creator A5077340922 @default.
• W1969504080 date "2003-11-01" @default.
• W1969504080 modified "2023-10-12" @default.
• W1969504080 title "Discordant expression of perforin and granzyme A in total and HIV-specific CD8 T lymphocytes of HIV infected children and adolescents" @default.
• W1969504080 cites W1251599274 @default.
• W1969504080 cites W1572252257 @default.
• W1969504080 cites W1945834141 @default.
• W1969504080 cites W1964017617 @default.
• W1969504080 cites W1976433083 @default.
• W1969504080 cites W1994340919 @default.
• W1969504080 cites W2001815433 @default.
• W1969504080 cites W2032598206 @default.
• W1969504080 cites W2037343680 @default.
• W1969504080 cites W2038599188 @default.
• W1969504080 cites W2057586368 @default.
• W1969504080 cites W2068480046 @default.
• W1969504080 cites W2069340283 @default.
• W1969504080 cites W2071505061 @default.
• W1969504080 cites W2072056970 @default.
• W1969504080 cites W2075757807 @default.
• W1969504080 cites W2091320091 @default.
• W1969504080 cites W2103182811 @default.
• W1969504080 cites W2105283662 @default.
• W1969504080 cites W2110211157 @default.
• W1969504080 cites W2112601022 @default.
• W1969504080 cites W2114098868 @default.
• W1969504080 cites W2119232577 @default.
• W1969504080 cites W2121976570 @default.
• W1969504080 cites W2126302947 @default.
• W1969504080 cites W2129114331 @default.
• W1969504080 cites W2132385533 @default.
• W1969504080 cites W2144040832 @default.
• W1969504080 cites W2149762625 @default.
• W1969504080 cites W2166883229 @default.
• W1969504080 cites W2339173512 @default.
• W1969504080 doi "https://doi.org/10.1097/00002030-200311070-00005" @default.
• W1969504080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14571182" @default.
• W1969504080 hasPublicationYear "2003" @default.
• W1969504080 type Work @default.
• W1969504080 sameAs 1969504080 @default.
• W1969504080 citedByCount "21" @default.
• W1969504080 countsByYear W19695040802013 @default.
• W1969504080 countsByYear W19695040802015 @default.
• W1969504080 countsByYear W19695040802018 @default.
• W1969504080 countsByYear W19695040802019 @default.
• W1969504080 countsByYear W19695040802020 @default.
• W1969504080 countsByYear W19695040802022 @default.
• W1969504080 crossrefType "journal-article" @default.
• W1969504080 hasAuthorship W1969504080A5002278563 @default.
• W1969504080 hasAuthorship W1969504080A5048785797 @default.
• W1969504080 hasAuthorship W1969504080A5067199049 @default.
• W1969504080 hasAuthorship W1969504080A5077340922 @default.
• W1969504080 hasBestOaLocation W19695040801 @default.
• W1969504080 hasConcept C129374314 @default.
• W1969504080 hasConcept C154317977 @default.
• W1969504080 hasConcept C167672396 @default.
• W1969504080 hasConcept C183193105 @default.
• W1969504080 hasConcept C202751555 @default.
• W1969504080 hasConcept C203014093 @default.
• W1969504080 hasConcept C2776062744 @default.
• W1969504080 hasConcept C2779968557 @default.
• W1969504080 hasConcept C2780380082 @default.
• W1969504080 hasConcept C55493867 @default.
• W1969504080 hasConcept C86803240 @default.
• W1969504080 hasConcept C8891405 @default.
• W1969504080 hasConceptScore W1969504080C129374314 @default.
• W1969504080 hasConceptScore W1969504080C154317977 @default.
• W1969504080 hasConceptScore W1969504080C167672396 @default.
• W1969504080 hasConceptScore W1969504080C183193105 @default.
• W1969504080 hasConceptScore W1969504080C202751555 @default.
• W1969504080 hasConceptScore W1969504080C203014093 @default.
• W1969504080 hasConceptScore W1969504080C2776062744 @default.
• W1969504080 hasConceptScore W1969504080C2779968557 @default.
• W1969504080 hasConceptScore W1969504080C2780380082 @default.
• W1969504080 hasConceptScore W1969504080C55493867 @default.
• W1969504080 hasConceptScore W1969504080C86803240 @default.
• W1969504080 hasConceptScore W1969504080C8891405 @default.
• W1969504080 hasIssue "16" @default.
• W1969504080 hasLocation W19695040801 @default.
• W1969504080 hasLocation W19695040802 @default.
• W1969504080 hasLocation W19695040803 @default.
• W1969504080 hasOpenAccess W1969504080 @default.
• W1969504080 hasPrimaryLocation W19695040801 @default.
• W1969504080 hasRelatedWork W150405246 @default.
• W1969504080 hasRelatedWork W1958134254 @default.
• W1969504080 hasRelatedWork W1986880637 @default.
• W1969504080 hasRelatedWork W1991275224 @default.
• W1969504080 hasRelatedWork W1991773024 @default.
• W1969504080 hasRelatedWork W2083502121 @default.
• W1969504080 hasRelatedWork W2107858772 @default.
• W1969504080 hasRelatedWork W2409853799 @default.
• W1969504080 hasRelatedWork W3032016103 @default.
• W1969504080 hasRelatedWork W4214634819 @default.

• next