FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969507008> ?p ?o ?g. }

• W1969507008 endingPage "2136" @default.
• W1969507008 startingPage "2125" @default.
• W1969507008 abstract "RGS18 was originally identified as a R4 subfamily member of regulators of G-protein signaling (RGS) with specific expression in hematopoietic progenitors, myeloerythroid cells, and megakaryocytes, though its physiological role in hematopoiesis remained unknown. Here, we show that lentiviral RGS18 overexpression during differentiation of mouse Sca1(+) hematopoietic stem cells induced a 50% increase of megakaryocyte proliferation. RGS18 depletion in zebrafish results in thrombocytopenia, as 66 to 88% of the embryos lack thrombocytes after injection of an ATG or splice-blocking morpholino, respectively. These embryos have no defects in early hematopoiesis, erythropoiesis, or leukocyte number and migration. In addition, all RGS18 depleted embryos have curly tails and an almost absent response to acoustic stimuli. In situ hybridization in zebrafish, Xenopus, and mouse embryos shows RGS18 expression in thrombocytes and/or hematological tissues but also in brain and otic vesicles. RGS18 interferes with development of cilia in hair cells of the inner ear and neuromast cells. On the basis of literature evidence that RGS-R4 members interact with the G-protein-modulated Wnt/calcium pathway, Wnt5b- but not Wnt5a-depleted embryos phenocopy all RGS18 knockdown effects. In summary, our study is the first to show that RGS18 regulates megakaryopoiesis but also reveals its unexpected role in ciliogenesis, at least in lower vertebrates, via interference with Wnt signaling." @default.
• W1969507008 created "2016-06-24" @default.
• W1969507008 creator A5003479425 @default.
• W1969507008 creator A5005131513 @default.
• W1969507008 creator A5024467624 @default.
• W1969507008 creator A5031719052 @default.
• W1969507008 creator A5044112097 @default.
• W1969507008 creator A5056676933 @default.
• W1969507008 creator A5059991336 @default.
• W1969507008 creator A5064832605 @default.
• W1969507008 creator A5071146243 @default.
• W1969507008 creator A5077242768 @default.
• W1969507008 date "2012-02-03" @default.
• W1969507008 modified "2023-09-23" @default.
• W1969507008 title "Regulator of G‐protein signaling 18 controls megakaryopoiesis and the cilia‐mediated vertebrate mechanosensory system" @default.
• W1969507008 cites W1510328954 @default.
• W1969507008 cites W1592140990 @default.
• W1969507008 cites W1604265468 @default.
• W1969507008 cites W1844237590 @default.
• W1969507008 cites W1953109900 @default.
• W1969507008 cites W1970820951 @default.
• W1969507008 cites W1971047575 @default.
• W1969507008 cites W1971874676 @default.
• W1969507008 cites W1984931573 @default.
• W1969507008 cites W1986074519 @default.
• W1969507008 cites W1998361495 @default.
• W1969507008 cites W1998609280 @default.
• W1969507008 cites W1999583992 @default.
• W1969507008 cites W2000140559 @default.
• W1969507008 cites W2006070336 @default.
• W1969507008 cites W2007060113 @default.
• W1969507008 cites W2012340768 @default.
• W1969507008 cites W2015890115 @default.
• W1969507008 cites W2050865285 @default.
• W1969507008 cites W2053074918 @default.
• W1969507008 cites W2058843751 @default.
• W1969507008 cites W2064477296 @default.
• W1969507008 cites W2075008830 @default.
• W1969507008 cites W2080875376 @default.
• W1969507008 cites W2088291857 @default.
• W1969507008 cites W2088903662 @default.
• W1969507008 cites W2091508032 @default.
• W1969507008 cites W2097416336 @default.
• W1969507008 cites W2105279073 @default.
• W1969507008 cites W2106303663 @default.
• W1969507008 cites W2111479560 @default.
• W1969507008 cites W2125619701 @default.
• W1969507008 cites W2130514122 @default.
• W1969507008 cites W2140328069 @default.
• W1969507008 cites W2143952155 @default.
• W1969507008 cites W2147821804 @default.
• W1969507008 cites W2148289179 @default.
• W1969507008 cites W2150303379 @default.
• W1969507008 cites W2175016040 @default.
• W1969507008 cites W2208796000 @default.
• W1969507008 doi "https://doi.org/10.1096/fj.11-198739" @default.
• W1969507008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22308195" @default.
• W1969507008 hasPublicationYear "2012" @default.
• W1969507008 type Work @default.
• W1969507008 sameAs 1969507008 @default.
• W1969507008 citedByCount "25" @default.
• W1969507008 countsByYear W19695070082012 @default.
• W1969507008 countsByYear W19695070082013 @default.
• W1969507008 countsByYear W19695070082014 @default.
• W1969507008 countsByYear W19695070082015 @default.
• W1969507008 countsByYear W19695070082016 @default.
• W1969507008 countsByYear W19695070082017 @default.
• W1969507008 countsByYear W19695070082018 @default.
• W1969507008 countsByYear W19695070082020 @default.
• W1969507008 countsByYear W19695070082021 @default.
• W1969507008 countsByYear W19695070082022 @default.
• W1969507008 countsByYear W19695070082023 @default.
• W1969507008 crossrefType "journal-article" @default.
• W1969507008 hasAuthorship W1969507008A5003479425 @default.
• W1969507008 hasAuthorship W1969507008A5005131513 @default.
• W1969507008 hasAuthorship W1969507008A5024467624 @default.
• W1969507008 hasAuthorship W1969507008A5031719052 @default.
• W1969507008 hasAuthorship W1969507008A5044112097 @default.
• W1969507008 hasAuthorship W1969507008A5056676933 @default.
• W1969507008 hasAuthorship W1969507008A5059991336 @default.
• W1969507008 hasAuthorship W1969507008A5064832605 @default.
• W1969507008 hasAuthorship W1969507008A5071146243 @default.
• W1969507008 hasAuthorship W1969507008A5077242768 @default.
• W1969507008 hasConcept C100094513 @default.
• W1969507008 hasConcept C104317684 @default.
• W1969507008 hasConcept C109159458 @default.
• W1969507008 hasConcept C137620995 @default.
• W1969507008 hasConcept C195267511 @default.
• W1969507008 hasConcept C2776878037 @default.
• W1969507008 hasConcept C28328180 @default.
• W1969507008 hasConcept C54355233 @default.
• W1969507008 hasConcept C62478195 @default.
• W1969507008 hasConcept C86803240 @default.
• W1969507008 hasConcept C95444343 @default.
• W1969507008 hasConceptScore W1969507008C100094513 @default.
• W1969507008 hasConceptScore W1969507008C104317684 @default.
• W1969507008 hasConceptScore W1969507008C109159458 @default.
• W1969507008 hasConceptScore W1969507008C137620995 @default.

• next