FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969517762> ?p ?o ?g. }

• W1969517762 endingPage "2736" @default.
• W1969517762 startingPage "2725" @default.
• W1969517762 abstract "Antigen-specific immunotherapy is an attractive strategy for cancer control. In the context of antiviral vaccines, adenoviral vectors have emerged as a favorable means for immunization. Therefore, we chose a strategy combining use of these vectors with another successful approach, namely linkage of the vaccine antigen to invariant chain (Ii). To evaluate this strategy we used a mouse model, in which an immunodominant epitope (GP33) of the LCMV glycoprotein (GP) represents the tumor-associated neoantigen. Prophylactic vaccination of C57BL/6 mice with a replication-deficient human adenovirus 5 vector encoding GP linked to Ii (Ad-Ii-GP) resulted in complete protection against GP33-expressing B16.F10 tumors. Therapeutic vaccination with Ad-Ii-GP delayed tumor growth by more than 2 wk compared with sham vaccination. Notably, therapeutic vaccination with the linked vaccine was significantly better than vaccination with adenovirus expressing GP alone (Ad-GP), or GP and Ii unlinked (Ad-GP+Ii). Ad-Ii-GP- induced tumor control depended on an improved generation of the tumor-associated neoantigen-specific CD8+ T-cell response and was independent of CD4+ T cells. IFN-γ was shown to be a key player during the tumor degradation. Finally, Ad-Ii-GP but not Ad-GP vaccination can break the immunological non-reactivity in GP transgenic mice indicating that our vaccine strategy will prove efficient also against endogenous tumor antigens." @default.
• W1969517762 created "2016-06-24" @default.
• W1969517762 creator A5012450083 @default.
• W1969517762 creator A5021016134 @default.
• W1969517762 creator A5038335267 @default.
• W1969517762 creator A5046951838 @default.
• W1969517762 creator A5062793154 @default.
• W1969517762 date "2009-10-01" @default.
• W1969517762 modified "2023-09-24" @default.
• W1969517762 title "Vaccination with an adenoviral vector encoding the tumor antigen directly linked to invariant chain induces potent CD4⁺T-cell-independent CD8⁺T-cell-mediated tumor control" @default.
• W1969517762 cites W1582627386 @default.
• W1969517762 cites W1868320223 @default.
• W1969517762 cites W1869945334 @default.
• W1969517762 cites W1972997485 @default.
• W1969517762 cites W1987058037 @default.
• W1969517762 cites W1987423758 @default.
• W1969517762 cites W1993449561 @default.
• W1969517762 cites W1995201985 @default.
• W1969517762 cites W2010692342 @default.
• W1969517762 cites W2013525973 @default.
• W1969517762 cites W2017850328 @default.
• W1969517762 cites W2026318599 @default.
• W1969517762 cites W2033229279 @default.
• W1969517762 cites W2045320547 @default.
• W1969517762 cites W2071758752 @default.
• W1969517762 cites W2075453847 @default.
• W1969517762 cites W2093619015 @default.
• W1969517762 cites W2095862992 @default.
• W1969517762 cites W2104045882 @default.
• W1969517762 cites W2107526519 @default.
• W1969517762 cites W2114601875 @default.
• W1969517762 cites W2122541507 @default.
• W1969517762 cites W2124871789 @default.
• W1969517762 cites W2127345627 @default.
• W1969517762 cites W2129088290 @default.
• W1969517762 cites W2138501667 @default.
• W1969517762 cites W2141102490 @default.
• W1969517762 cites W2143080883 @default.
• W1969517762 cites W2144300713 @default.
• W1969517762 cites W2151838794 @default.
• W1969517762 cites W2160193764 @default.
• W1969517762 cites W2167017590 @default.
• W1969517762 cites W2320254486 @default.
• W1969517762 cites W4313342460 @default.
• W1969517762 cites W988054948 @default.
• W1969517762 doi "https://doi.org/10.1002/eji.200939543" @default.
• W1969517762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19637230" @default.
• W1969517762 hasPublicationYear "2009" @default.
• W1969517762 type Work @default.
• W1969517762 sameAs 1969517762 @default.
• W1969517762 citedByCount "45" @default.
• W1969517762 countsByYear W19695177622012 @default.
• W1969517762 countsByYear W19695177622013 @default.
• W1969517762 countsByYear W19695177622014 @default.
• W1969517762 countsByYear W19695177622015 @default.
• W1969517762 countsByYear W19695177622016 @default.
• W1969517762 countsByYear W19695177622017 @default.
• W1969517762 countsByYear W19695177622018 @default.
• W1969517762 countsByYear W19695177622019 @default.
• W1969517762 countsByYear W19695177622020 @default.
• W1969517762 countsByYear W19695177622021 @default.
• W1969517762 countsByYear W19695177622023 @default.
• W1969517762 crossrefType "journal-article" @default.
• W1969517762 hasAuthorship W1969517762A5012450083 @default.
• W1969517762 hasAuthorship W1969517762A5021016134 @default.
• W1969517762 hasAuthorship W1969517762A5038335267 @default.
• W1969517762 hasAuthorship W1969517762A5046951838 @default.
• W1969517762 hasAuthorship W1969517762A5062793154 @default.
• W1969517762 hasBestOaLocation W19695177621 @default.
• W1969517762 hasConcept C104317684 @default.
• W1969517762 hasConcept C111599444 @default.
• W1969517762 hasConcept C147483822 @default.
• W1969517762 hasConcept C154317977 @default.
• W1969517762 hasConcept C159047783 @default.
• W1969517762 hasConcept C167672396 @default.
• W1969517762 hasConcept C195616568 @default.
• W1969517762 hasConcept C202751555 @default.
• W1969517762 hasConcept C203014093 @default.
• W1969517762 hasConcept C22070199 @default.
• W1969517762 hasConcept C2776090121 @default.
• W1969517762 hasConcept C2776954459 @default.
• W1969517762 hasConcept C2777701055 @default.
• W1969517762 hasConcept C2780801004 @default.
• W1969517762 hasConcept C32470452 @default.
• W1969517762 hasConcept C40767141 @default.
• W1969517762 hasConcept C54355233 @default.
• W1969517762 hasConcept C86803240 @default.
• W1969517762 hasConcept C8891405 @default.
• W1969517762 hasConceptScore W1969517762C104317684 @default.
• W1969517762 hasConceptScore W1969517762C111599444 @default.
• W1969517762 hasConceptScore W1969517762C147483822 @default.
• W1969517762 hasConceptScore W1969517762C154317977 @default.
• W1969517762 hasConceptScore W1969517762C159047783 @default.
• W1969517762 hasConceptScore W1969517762C167672396 @default.
• W1969517762 hasConceptScore W1969517762C195616568 @default.
• W1969517762 hasConceptScore W1969517762C202751555 @default.
• W1969517762 hasConceptScore W1969517762C203014093 @default.
• W1969517762 hasConceptScore W1969517762C22070199 @default.

• next