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• W1969520399 abstract "Madagascan periwinkle is the current source of (+)-catharanthine, the crucial building block of the major antitumor agent vinorelbine. In the formal synthesis of this natural product, the key intermediate 1 described by Büchi and co-workers was obtained in virtually optically pure form from L-serine. The strategy presented may be viewed as a general synthetic approach to optically active isoquinuclidines. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z601307_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article." @default.
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• W1969520399 date "2006-08-07" @default.
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• W1969520399 title "Formal Synthesis of (+)-Catharanthine" @default.
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• W1969520399 doi "https://doi.org/10.1002/anie.200601307" @default.
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