FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969547131> ?p ?o ?g. }

• W1969547131 endingPage "627" @default.
• W1969547131 startingPage "617" @default.
• W1969547131 abstract "The aquaporins (AQP) are a family of homologous water channels expressed in many epithelial and endothelial cell types involved in fluid transport. AQP1 protein is strongly expressed in most microvascular endothelia outside of the brain, as well as in endothelial cells in cornea, intestinal lacteals, and other tissues. AQP4 is expressed in astroglial foot processes adjacent to endothelial cells in the central nervous system. Transgenic mice lacking aquaporins have been useful in defining their role in mammalian physiology. Mice lacking AQP1 manifest defective urinary concentrating ability, in part because of decreased water permeability in renal vasa recta microvessels. These mice also show a defect in dietary fat processing that may involve chylomicron absorption by intestinal lacteals, as well as defective active fluid transport across the corneal endothelium. AQP1 might also play a role in tumour angiogenesis and in renal microvessel structural adaptation. However, AQP1 in most endothelial tissues does not appear to have a physiological function despite its role in osmotically driven water transport. For example, mice lacking AQP1 have low alveolar-capillary water permeability but unimpaired lung fluid absorption, as well as unimpaired saliva and tear secretion, aqueous fluid outflow, and pleural and peritoneal fluid transport. In the central nervous system mice lacking AQP4 are partially protected from brain oedema in water intoxication and ischaemic models of brain injury. Therefore, although the role of aquaporins in epithelial fluid transport is in most cases well-understood, there remain many questions about the role of aquaporins in endothelial cell function. It is unclear why many leaky microvessels strongly express AQP1 without apparent functional significance. Improved understanding of aquaporin-endothelial biology may lead to novel therapies for human disease, such as pharmacological modulation of corneal fluid transport, renal fluid clearance and intestinal absorption." @default.
• W1969547131 created "2016-06-24" @default.
• W1969547131 creator A5042356327 @default.
• W1969547131 date "2002-06-01" @default.
• W1969547131 modified "2023-10-18" @default.
• W1969547131 title "Aquaporin water channels and endothelial cell function*" @default.
• W1969547131 cites W1495656315 @default.
• W1969547131 cites W1527744402 @default.
• W1969547131 cites W1535419310 @default.
• W1969547131 cites W1611592297 @default.
• W1969547131 cites W1829661407 @default.
• W1969547131 cites W1831896296 @default.
• W1969547131 cites W1852199856 @default.
• W1969547131 cites W1924153403 @default.
• W1969547131 cites W1944808610 @default.
• W1969547131 cites W1964474152 @default.
• W1969547131 cites W1970929493 @default.
• W1969547131 cites W1974228630 @default.
• W1969547131 cites W1974587361 @default.
• W1969547131 cites W1980044885 @default.
• W1969547131 cites W1984284559 @default.
• W1969547131 cites W1986968716 @default.
• W1969547131 cites W1988343729 @default.
• W1969547131 cites W1993064394 @default.
• W1969547131 cites W1995178724 @default.
• W1969547131 cites W1997685015 @default.
• W1969547131 cites W2000724701 @default.
• W1969547131 cites W2006649522 @default.
• W1969547131 cites W2006823250 @default.
• W1969547131 cites W2007677916 @default.
• W1969547131 cites W2008726342 @default.
• W1969547131 cites W2011296548 @default.
• W1969547131 cites W2019895168 @default.
• W1969547131 cites W2020099135 @default.
• W1969547131 cites W2020839799 @default.
• W1969547131 cites W2030142994 @default.
• W1969547131 cites W2032482731 @default.
• W1969547131 cites W2038507903 @default.
• W1969547131 cites W2040711639 @default.
• W1969547131 cites W2042577267 @default.
• W1969547131 cites W2045611996 @default.
• W1969547131 cites W2057761610 @default.
• W1969547131 cites W2064057102 @default.
• W1969547131 cites W2072251236 @default.
• W1969547131 cites W2075279965 @default.
• W1969547131 cites W2078859316 @default.
• W1969547131 cites W2079126167 @default.
• W1969547131 cites W2104211875 @default.
• W1969547131 cites W2110059758 @default.
• W1969547131 cites W2115956096 @default.
• W1969547131 cites W2124292468 @default.
• W1969547131 cites W2128470150 @default.
• W1969547131 cites W2130732804 @default.
• W1969547131 cites W2132935598 @default.
• W1969547131 cites W2132953007 @default.
• W1969547131 cites W2136288803 @default.
• W1969547131 cites W2137671217 @default.
• W1969547131 cites W2138651864 @default.
• W1969547131 cites W2151489565 @default.
• W1969547131 cites W2154009044 @default.
• W1969547131 cites W2154621600 @default.
• W1969547131 cites W2154658925 @default.
• W1969547131 cites W2159873016 @default.
• W1969547131 cites W2168615296 @default.
• W1969547131 cites W2169182692 @default.
• W1969547131 cites W2172238479 @default.
• W1969547131 cites W2334838478 @default.
• W1969547131 cites W5338072 @default.
• W1969547131 cites W54418235 @default.
• W1969547131 cites W74101389 @default.
• W1969547131 doi "https://doi.org/10.1046/j.1469-7580.2002.00058.x" @default.
• W1969547131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1570747" @default.
• W1969547131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12162729" @default.
• W1969547131 hasPublicationYear "2002" @default.
• W1969547131 type Work @default.
• W1969547131 sameAs 1969547131 @default.
• W1969547131 citedByCount "226" @default.
• W1969547131 countsByYear W19695471312012 @default.
• W1969547131 countsByYear W19695471312013 @default.
• W1969547131 countsByYear W19695471312014 @default.
• W1969547131 countsByYear W19695471312015 @default.
• W1969547131 countsByYear W19695471312016 @default.
• W1969547131 countsByYear W19695471312017 @default.
• W1969547131 countsByYear W19695471312018 @default.
• W1969547131 countsByYear W19695471312019 @default.
• W1969547131 countsByYear W19695471312020 @default.
• W1969547131 countsByYear W19695471312021 @default.
• W1969547131 countsByYear W19695471312022 @default.
• W1969547131 countsByYear W19695471312023 @default.
• W1969547131 crossrefType "journal-article" @default.
• W1969547131 hasAuthorship W1969547131A5042356327 @default.
• W1969547131 hasBestOaLocation W19695471312 @default.
• W1969547131 hasConcept C123012128 @default.
• W1969547131 hasConcept C127413603 @default.
• W1969547131 hasConcept C134018914 @default.
• W1969547131 hasConcept C154280991 @default.
• W1969547131 hasConcept C177586851 @default.
• W1969547131 hasConcept C201289731 @default.

• next