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- W1969553718 endingPage "939" @default.
- W1969553718 startingPage "927" @default.
- W1969553718 abstract "Homocysteine levels have been associated with major depression, but associations with bipolar disorder remain less clear. Some data suggest homocysteine levels have potential as a biomarker of treatment response; however the literature is mixed.Oxidized forms of homocysteine can be potentially neurotoxic leading to glutamate toxicity, apoptotic transformation and neurodegenerative processes. High homocysteine may be a risk biomarker for bipolar disorders, but the empirical base remains too weak for firm conclusions. This review discusses the current literature for homocysteine levels as a biomarker.It is premature to foreclose the utility of homocysteine levels as a biomarker for bipolar disorder due the methodological inadequacies in the existing literature. These methodological design issues include lack of control for the confounding variables of concurrent medication, phase of bipolar disorder, gender, age, nutritional status, thyroid, liver and renal function, smoking or lean body mass. Well-powered association studies with confounder control could help shed more light on the important clinical question of homocysteine's utility as a biomarker in bipolar disorder. Future experiments are needed to examine the outcome of interventions modulating homocysteine for treating bipolar disorder. Only prospective randomized control trials will provide definitive evidence of the utility of homocysteine as a biomarker or therapeutic target." @default.
- W1969553718 created "2016-06-24" @default.
- W1969553718 creator A5057433113 @default.
- W1969553718 creator A5062932958 @default.
- W1969553718 creator A5067863611 @default.
- W1969553718 creator A5078882374 @default.
- W1969553718 date "2015-04-16" @default.
- W1969553718 modified "2023-10-16" @default.
- W1969553718 title "Homocysteine as a potential biomarker in bipolar disorders: a critical review and suggestions for improved studies" @default.
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- W1969553718 doi "https://doi.org/10.1517/14728222.2015.1019866" @default.
- W1969553718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25882812" @default.
- W1969553718 hasPublicationYear "2015" @default.