Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969554397> ?p ?o ?g. }
- W1969554397 endingPage "158" @default.
- W1969554397 startingPage "144" @default.
- W1969554397 abstract "VEGFA signaling is critical for endothelial and hematopoietic stem cell (HSC) specification. However, blood defects resulting from perturbation of the VEGFA pathway are always accompanied by impaired vascular/arterial development. Because HSCs derive from arterial cells, it is unclear whether VEGFA directly contributes to HSC specification. This is an important question for our understanding of how HSCs are formed and for developing their production in vitro. Through knockdown of the regulator ETO2 in embryogenesis, we report a specific decrease in expression of medium/long Vegfa isoforms in somites. This leads to absence of Notch1 expression and failure of HSC specification in the dorsal aorta (DA), independently of vessel formation and arterial specification. Vegfa hypomorphs and isoform-specific (medium/long) morphants not only recapitulate this phenotype but also demonstrate that VEGFA short isoform is sufficient for DA development. Therefore, sequential, isoform-specific VEGFA signaling successively induces the endothelial, arterial, and HSC programs in the DA." @default.
- W1969554397 created "2016-06-24" @default.
- W1969554397 creator A5004936770 @default.
- W1969554397 creator A5010051623 @default.
- W1969554397 creator A5016317673 @default.
- W1969554397 creator A5028913227 @default.
- W1969554397 creator A5049267618 @default.
- W1969554397 creator A5054408146 @default.
- W1969554397 creator A5068869985 @default.
- W1969554397 creator A5082317757 @default.
- W1969554397 date "2013-01-01" @default.
- W1969554397 modified "2023-10-16" @default.
- W1969554397 title "Uncoupling VEGFA Functions in Arteriogenesis and Hematopoietic Stem Cell Specification" @default.
- W1969554397 cites W1824539617 @default.
- W1969554397 cites W1966443300 @default.
- W1969554397 cites W1971038955 @default.
- W1969554397 cites W1976305272 @default.
- W1969554397 cites W1977842421 @default.
- W1969554397 cites W1982111644 @default.
- W1969554397 cites W1985920188 @default.
- W1969554397 cites W1991362893 @default.
- W1969554397 cites W1992049575 @default.
- W1969554397 cites W1997300044 @default.
- W1969554397 cites W2005093123 @default.
- W1969554397 cites W2010301106 @default.
- W1969554397 cites W2023303970 @default.
- W1969554397 cites W2030608150 @default.
- W1969554397 cites W2031587505 @default.
- W1969554397 cites W2032911882 @default.
- W1969554397 cites W2038264930 @default.
- W1969554397 cites W2042072123 @default.
- W1969554397 cites W2045247659 @default.
- W1969554397 cites W2048121906 @default.
- W1969554397 cites W2056916102 @default.
- W1969554397 cites W2057556321 @default.
- W1969554397 cites W2057972414 @default.
- W1969554397 cites W2064489090 @default.
- W1969554397 cites W2067872995 @default.
- W1969554397 cites W2086627604 @default.
- W1969554397 cites W2093498435 @default.
- W1969554397 cites W2097121011 @default.
- W1969554397 cites W2111812028 @default.
- W1969554397 cites W2113645473 @default.
- W1969554397 cites W2115181518 @default.
- W1969554397 cites W2129402330 @default.
- W1969554397 cites W2141805102 @default.
- W1969554397 cites W2143927198 @default.
- W1969554397 cites W2144470070 @default.
- W1969554397 cites W2146953551 @default.
- W1969554397 cites W2149161454 @default.
- W1969554397 cites W2155276021 @default.
- W1969554397 cites W2168736535 @default.
- W1969554397 doi "https://doi.org/10.1016/j.devcel.2012.12.004" @default.
- W1969554397 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3560039" @default.
- W1969554397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23318133" @default.
- W1969554397 hasPublicationYear "2013" @default.
- W1969554397 type Work @default.
- W1969554397 sameAs 1969554397 @default.
- W1969554397 citedByCount "57" @default.
- W1969554397 countsByYear W19695543972013 @default.
- W1969554397 countsByYear W19695543972014 @default.
- W1969554397 countsByYear W19695543972015 @default.
- W1969554397 countsByYear W19695543972016 @default.
- W1969554397 countsByYear W19695543972017 @default.
- W1969554397 countsByYear W19695543972018 @default.
- W1969554397 countsByYear W19695543972019 @default.
- W1969554397 countsByYear W19695543972020 @default.
- W1969554397 countsByYear W19695543972022 @default.
- W1969554397 countsByYear W19695543972023 @default.
- W1969554397 crossrefType "journal-article" @default.
- W1969554397 hasAuthorship W1969554397A5004936770 @default.
- W1969554397 hasAuthorship W1969554397A5010051623 @default.
- W1969554397 hasAuthorship W1969554397A5016317673 @default.
- W1969554397 hasAuthorship W1969554397A5028913227 @default.
- W1969554397 hasAuthorship W1969554397A5049267618 @default.
- W1969554397 hasAuthorship W1969554397A5054408146 @default.
- W1969554397 hasAuthorship W1969554397A5068869985 @default.
- W1969554397 hasAuthorship W1969554397A5082317757 @default.
- W1969554397 hasBestOaLocation W19695543971 @default.
- W1969554397 hasConcept C104317684 @default.
- W1969554397 hasConcept C109159458 @default.
- W1969554397 hasConcept C146285616 @default.
- W1969554397 hasConcept C167734588 @default.
- W1969554397 hasConcept C173396325 @default.
- W1969554397 hasConcept C2777025900 @default.
- W1969554397 hasConcept C2777408375 @default.
- W1969554397 hasConcept C2778086970 @default.
- W1969554397 hasConcept C2780394083 @default.
- W1969554397 hasConcept C28328180 @default.
- W1969554397 hasConcept C502942594 @default.
- W1969554397 hasConcept C53345823 @default.
- W1969554397 hasConcept C54355233 @default.
- W1969554397 hasConcept C6929976 @default.
- W1969554397 hasConcept C7104941 @default.
- W1969554397 hasConcept C81885089 @default.
- W1969554397 hasConcept C86803240 @default.
- W1969554397 hasConcept C95444343 @default.
- W1969554397 hasConceptScore W1969554397C104317684 @default.