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- W1969581169 abstract "The CNS might play an important pathophysiologic role in the induction of the adult respiratory distress syndrome (ARDS). Post-traumatic development of cerebral microthromboses seems to be a major feature. To test this hypothesis, we subjected Wistar rats with postburn ARDS to the following microneurosurgical procedures in an attempt to morphologically detect modifications in the evolving pattern: a) anterior (AH) or posterior (PH) hypothalamus nuclei stereotaxic electrolytic lesion; b) intracerebroventricular microinjections of phenoxybenzamine (PB)-50, micrograms propranolol-0.5 micrograms, cocaine-5 micrograms, epinephrine-0.5 micrograms, carbachol(CA)-5 micrograms, pirilamine-20 micrograms, cimetidine-30 micrograms, lidocaine-20 micrograms, atropine (AT)-40 micrograms; c) intra-AH microinjections of CA-10 micrograms, AT-20 micrograms; and d) intra-PH microinjections of PB-10 micrograms, norepinephrine-0.05 microgram. The results showed that the alpha-adrenergic components of PH induce a potentiation in ARDS whereas the cholinergic components of AH seem to attenuate this syndrome. This work suggests that a damaged CNS may suffer cybernetic derangements as to induce it to generate inappropriate adaptative responses that can result in the development of ARDS." @default.
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- W1969581169 date "1987-09-01" @default.
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- W1969581169 title "Role of the central nervous system in the adult respiratory distress syndrome" @default.
- W1969581169 doi "https://doi.org/10.1097/00003246-198709000-00009" @default.
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