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• W1969582246 endingPage "1132" @default.
• W1969582246 startingPage "1122" @default.
• W1969582246 abstract "Cisplatin (CDDP) is a chemotherapeutic agent that produces nephrotoxicity associated with oxidative/nitrosative stress. alpha-Mangostin (alpha-M) is a xanthone extracted from mangosteen with antioxidant and anti-inflammatory properties. The purpose of this study was to evaluate the renoprotective effect of alpha-M on the CDDP-induced nephrotoxicity. alpha-M was administered (12.5 mg/kg/day, i.g.) for 10 days (7 days before and 3 days after CDDP injection). On day 7, rats were treated with a single injection of CDDP (7.5 mg/Kg, i.p.); 3 days after the rats were killed. alpha-M attenuated renal dysfunction, structural damage, oxidative/nitrosative stress, decrease in catalase expression and increase in mRNA levels of tumour necrosis factor alpha and transforming growth factor beta. In conclusion the renoprotective effect of alpha-M on CDDP-induced nephrotoxicity was associated with the attenuation in oxidative/nitrosative stress and inflammatory and fibrotic markers and preservation of catalase activity." @default.
• W1969582246 created "2016-06-24" @default.
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• W1969582246 date "2009-01-01" @default.
• W1969582246 modified "2023-10-18" @default.
• W1969582246 title "Renoprotection by<i>α</i>-mangostin is related to the attenuation in renal oxidative/nitrosative stress induced by cisplatin nephrotoxicity" @default.
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• W1969582246 doi "https://doi.org/10.1080/10715760903214447" @default.
• W1969582246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19863372" @default.
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