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- W1969584613 abstract "Methyl pyrrolidinone chitosan is being tested as a wound dressing material endowed of biological significance. In order to clarify its fate and role when applied to a surgical wound, its hydrolytic depolymerization by hen egg white lysozyme was studied in vitro. Viscometric measurements at three temperatures (25, 37 and 50°C) and five methyl pyrrolidinone chitosan concentrations (9·0, 13·5, 18·0, 23·5 and 27·3 g litre−1) permitted kinetic data to be obtained, including the Michaelis constant, 1 × 10−4 mol litre−1. Linearity was observed when log KM was plotted versus1T. The viscosity decrease over the 50 min period of observation was a linear function of temperature, independent of the initial substrate concentration. It is concluded that methyl pyrrolidinone chitosan is susceptible to enzymatic hydrolysis and therefore it is an absorbable medical aid. Results support the hypothesis that depolymerized methyl pyrrolidinone chitosan in vivo would become available for tissue reconstruction." @default.
- W1969584613 created "2016-06-24" @default.
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- W1969584613 date "1992-01-01" @default.
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- W1969584613 title "Depolymerization of methyl pyrrolidinone chitosan by lysozyme" @default.
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- W1969584613 doi "https://doi.org/10.1016/0144-8617(92)90051-q" @default.
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