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- W1969591738 abstract "1. The base composition of the acid-soluble nucleotides released during early stages of the attack of micrococcal nuclease on DNA depends on substrate conformation and temperature. The enzyme attacks native DNA initially in dA-dT rich regions, while attack on heat-denatured DNA is random, yielding acid-soluble material of average composition (approx. 58 mole % (dA+dT) for calf thymus DNA). The ‘preference’ of the enzyme for dA-dT rich sequences of native DNA increases as the reaction temperature is decreased, yielding an initial acid-soluble product containing 88 mole % (dA+dT) for calf thymus DNA when the enzymatic digestion is carried out at 10°. 2. Experiments with mixtures of native and denatured DNA show that the enzyme hydrolyzes the denatured material preferentially, taking up the sequence specificity pattern characteristic of native DNA hydrolysis only after the denatured substrate has been exhausted. 3. The results obtained support previous suggestions that the specificity of the attack of micrococcal nuclease on the native DNA structure depends on sequence-dependent differences in the conformational motility (‘breathing’ or ‘dynamic’ structure) of various regions of the DNA molecule." @default.
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- W1969591738 date "1968-03-01" @default.
- W1969591738 modified "2023-09-26" @default.
- W1969591738 title "The conformation dependent hydrolysis of DNA by micrococcal nuclease" @default.
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- W1969591738 doi "https://doi.org/10.1016/0005-2787(68)90270-0" @default.
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