Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969592016> ?p ?o ?g. }
- W1969592016 endingPage "154" @default.
- W1969592016 startingPage "149" @default.
- W1969592016 abstract "Basic fibroblast growth factor (bFGF) is a potent endothelial cell mitogen found in a variety of normal and tumor tissues. Basic FGF lacks a classical signal sequence, and it is not clear how it is released from cells. bFGF or bFGF-like activity has not been previously demonstrated in plasma. In an earlier study we showed increased mitogenic activity for parathyroidderived epithelial and mesenchymal cells in plasma of subjects with familial multiple endocrine neoplasia type 1 (FMEN1). In the present study we examined the growth-promoting activity of normal and FMENl plasmas [applied to heparin-Sepharose (HS) columns] in parathyroid-derived cloned endothelial cells. FMENl plasma HS-adsorbed activity exceeded normal plasma HS-adsorbed activity in 6 of 8 FMENl plasma samples. Peak (FMENl plasma) HS-adsorbed activity eluted with 0.1–0.3 m NaCl, was completely neutralized by specific antibodies against bFGF, and had an apparent mol wt of 110 kD. Active fractions from FMENl plasma prepared by gel filtration in 7 m urea displayed apparent mol wt of about 14–16 kD and showed increased apparent affinity for HS; recovered activity appeared principally in the 3.0-m NaCl eluate. Using a sensitive two-site immunoradiometric assay for bFGF we found 0.4 ng/mL bFGFlike immunoreactivity in the highly purified 3.0-m NaCl eluate from a HS column to which the active components from gel filtration of FMENl plasma in 7 m urea were applied. These results imply that bFGF or closely related factors circulate in FMENl." @default.
- W1969592016 created "2016-06-24" @default.
- W1969592016 creator A5004341345 @default.
- W1969592016 creator A5020484711 @default.
- W1969592016 creator A5036450244 @default.
- W1969592016 creator A5051586896 @default.
- W1969592016 creator A5052849207 @default.
- W1969592016 creator A5053932502 @default.
- W1969592016 creator A5055069129 @default.
- W1969592016 creator A5066988598 @default.
- W1969592016 creator A5083229654 @default.
- W1969592016 creator A5083708498 @default.
- W1969592016 date "1990-01-01" @default.
- W1969592016 modified "2023-10-18" @default.
- W1969592016 title "Circulating Fibroblast Growth Factor-Like Substance in Familial Multiple Endocrine Neoplasia Type 1*" @default.
- W1969592016 cites W1573798878 @default.
- W1969592016 cites W1591495971 @default.
- W1969592016 cites W1608448958 @default.
- W1969592016 cites W1966999658 @default.
- W1969592016 cites W1980235826 @default.
- W1969592016 cites W1984648137 @default.
- W1969592016 cites W2002555237 @default.
- W1969592016 cites W2004406911 @default.
- W1969592016 cites W2024787221 @default.
- W1969592016 cites W2033705784 @default.
- W1969592016 cites W2039213845 @default.
- W1969592016 cites W2046233216 @default.
- W1969592016 cites W2052272608 @default.
- W1969592016 cites W2055579373 @default.
- W1969592016 cites W2055702895 @default.
- W1969592016 cites W2057124511 @default.
- W1969592016 cites W2061230824 @default.
- W1969592016 cites W2073049752 @default.
- W1969592016 cites W2082267164 @default.
- W1969592016 cites W2084391108 @default.
- W1969592016 cites W2091173129 @default.
- W1969592016 cites W2098856542 @default.
- W1969592016 cites W2111544730 @default.
- W1969592016 cites W2139998567 @default.
- W1969592016 doi "https://doi.org/10.1210/jcem-70-1-149" @default.
- W1969592016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1967177" @default.
- W1969592016 hasPublicationYear "1990" @default.
- W1969592016 type Work @default.
- W1969592016 sameAs 1969592016 @default.
- W1969592016 citedByCount "67" @default.
- W1969592016 countsByYear W19695920162013 @default.
- W1969592016 countsByYear W19695920162016 @default.
- W1969592016 countsByYear W19695920162021 @default.
- W1969592016 countsByYear W19695920162023 @default.
- W1969592016 crossrefType "journal-article" @default.
- W1969592016 hasAuthorship W1969592016A5004341345 @default.
- W1969592016 hasAuthorship W1969592016A5020484711 @default.
- W1969592016 hasAuthorship W1969592016A5036450244 @default.
- W1969592016 hasAuthorship W1969592016A5051586896 @default.
- W1969592016 hasAuthorship W1969592016A5052849207 @default.
- W1969592016 hasAuthorship W1969592016A5053932502 @default.
- W1969592016 hasAuthorship W1969592016A5055069129 @default.
- W1969592016 hasAuthorship W1969592016A5066988598 @default.
- W1969592016 hasAuthorship W1969592016A5083229654 @default.
- W1969592016 hasAuthorship W1969592016A5083708498 @default.
- W1969592016 hasConcept C126322002 @default.
- W1969592016 hasConcept C134018914 @default.
- W1969592016 hasConcept C153911025 @default.
- W1969592016 hasConcept C170493617 @default.
- W1969592016 hasConcept C176685330 @default.
- W1969592016 hasConcept C181199279 @default.
- W1969592016 hasConcept C185592680 @default.
- W1969592016 hasConcept C193363816 @default.
- W1969592016 hasConcept C2775960820 @default.
- W1969592016 hasConcept C2777587049 @default.
- W1969592016 hasConcept C2778758028 @default.
- W1969592016 hasConcept C55493867 @default.
- W1969592016 hasConcept C71924100 @default.
- W1969592016 hasConcept C86803240 @default.
- W1969592016 hasConceptScore W1969592016C126322002 @default.
- W1969592016 hasConceptScore W1969592016C134018914 @default.
- W1969592016 hasConceptScore W1969592016C153911025 @default.
- W1969592016 hasConceptScore W1969592016C170493617 @default.
- W1969592016 hasConceptScore W1969592016C176685330 @default.
- W1969592016 hasConceptScore W1969592016C181199279 @default.
- W1969592016 hasConceptScore W1969592016C185592680 @default.
- W1969592016 hasConceptScore W1969592016C193363816 @default.
- W1969592016 hasConceptScore W1969592016C2775960820 @default.
- W1969592016 hasConceptScore W1969592016C2777587049 @default.
- W1969592016 hasConceptScore W1969592016C2778758028 @default.
- W1969592016 hasConceptScore W1969592016C55493867 @default.
- W1969592016 hasConceptScore W1969592016C71924100 @default.
- W1969592016 hasConceptScore W1969592016C86803240 @default.
- W1969592016 hasIssue "1" @default.
- W1969592016 hasLocation W19695920161 @default.
- W1969592016 hasLocation W19695920162 @default.
- W1969592016 hasOpenAccess W1969592016 @default.
- W1969592016 hasPrimaryLocation W19695920161 @default.
- W1969592016 hasRelatedWork W1982640511 @default.
- W1969592016 hasRelatedWork W1986705441 @default.
- W1969592016 hasRelatedWork W1995476527 @default.
- W1969592016 hasRelatedWork W2012899599 @default.
- W1969592016 hasRelatedWork W2018378707 @default.