FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969596581> ?p ?o ?g. }

• W1969596581 endingPage "e7980" @default.
• W1969596581 startingPage "e7980" @default.
• W1969596581 abstract "Background CD25, a component of the IL-2 receptor, is important in T cell proliferation, activation induced cell death, as well as the actions of both regulatory (Treg) and effector (Teff) T cells. Recent genome wide association studies have implicated the CD25 locus as an important region for genetic susceptibility to a number of autoimmune disorders, with serum levels of soluble CD25 receptor (sCD25) serving as a potential phenotypic marker for this association. However, the functional impact of CD25 cleavage, as well as the influence of sCD25 on immunoregulatory activities, remain largely unknown and form the basis of this effort. Methodology/Principal Findings The generation of sCD25 by Treg (CD4+CD25+) and Teff (CD4+CD25−) cells was examined during in vitro suppression assays, efforts that demonstrated constitutive and stable surface CD25 expression on Treg throughout the period of in vitro assessment. In contrast, Teff cells increased CD25 expression during the process of in vitro suppression, with supernatant sCD25 levels correlating to the amount of cellular proliferation. Interestingly, under serum-free conditions, Tregs partially lost their characteristic anergic and suppressive properties. sCD25 supplementation at physiological concentrations to serum free in vitro suppression assays reduced Teff proliferation without specifically influencing suppression. Indeed, sCD25 production within these cultures correlated with cell death. Conclusions/Significance These results support the notion that sCD25 functions as both a surrogate marker of T cell activation as well as an indicator of subsequent cellular death. In addition, the role of CD25 in immunomodulation is likely dependent on the local inflammatory milieu, with molecules capable of modulating surface CD25 expression playing a key role in defining immune responsiveness." @default.
• W1969596581 created "2016-06-24" @default.
• W1969596581 creator A5017911137 @default.
• W1969596581 creator A5044863989 @default.
• W1969596581 creator A5047782710 @default.
• W1969596581 creator A5060145442 @default.
• W1969596581 creator A5070437827 @default.
• W1969596581 creator A5086534495 @default.
• W1969596581 date "2009-11-24" @default.
• W1969596581 modified "2023-10-11" @default.
• W1969596581 title "Influence of Membrane CD25 Stability on T Lymphocyte Activity: Implications for Immunoregulation" @default.
• W1969596581 cites W1494043282 @default.
• W1969596581 cites W1512843295 @default.
• W1969596581 cites W1537606049 @default.
• W1969596581 cites W1560277370 @default.
• W1969596581 cites W1567420244 @default.
• W1969596581 cites W1568092992 @default.
• W1969596581 cites W1575437053 @default.
• W1969596581 cites W1733558371 @default.
• W1969596581 cites W1898102248 @default.
• W1969596581 cites W1965557074 @default.
• W1969596581 cites W1973154630 @default.
• W1969596581 cites W1978972286 @default.
• W1969596581 cites W1979068029 @default.
• W1969596581 cites W1984452374 @default.
• W1969596581 cites W2002424665 @default.
• W1969596581 cites W2022565486 @default.
• W1969596581 cites W2027127671 @default.
• W1969596581 cites W2031755982 @default.
• W1969596581 cites W2062766690 @default.
• W1969596581 cites W2068639447 @default.
• W1969596581 cites W2082331075 @default.
• W1969596581 cites W2090290726 @default.
• W1969596581 cites W2104476281 @default.
• W1969596581 cites W2109111910 @default.
• W1969596581 cites W2113288025 @default.
• W1969596581 cites W2116961420 @default.
• W1969596581 cites W2120010406 @default.
• W1969596581 cites W2144063967 @default.
• W1969596581 cites W2145122687 @default.
• W1969596581 cites W2146828787 @default.
• W1969596581 cites W2150747144 @default.
• W1969596581 cites W2156964052 @default.
• W1969596581 cites W2162639406 @default.
• W1969596581 cites W2162675860 @default.
• W1969596581 cites W2164392039 @default.
• W1969596581 cites W2170147688 @default.
• W1969596581 doi "https://doi.org/10.1371/journal.pone.0007980" @default.
• W1969596581 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2775921" @default.
• W1969596581 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19956753" @default.
• W1969596581 hasPublicationYear "2009" @default.
• W1969596581 type Work @default.
• W1969596581 sameAs 1969596581 @default.
• W1969596581 citedByCount "59" @default.
• W1969596581 countsByYear W19695965812012 @default.
• W1969596581 countsByYear W19695965812013 @default.
• W1969596581 countsByYear W19695965812014 @default.
• W1969596581 countsByYear W19695965812015 @default.
• W1969596581 countsByYear W19695965812016 @default.
• W1969596581 countsByYear W19695965812017 @default.
• W1969596581 countsByYear W19695965812018 @default.
• W1969596581 countsByYear W19695965812019 @default.
• W1969596581 countsByYear W19695965812020 @default.
• W1969596581 countsByYear W19695965812021 @default.
• W1969596581 countsByYear W19695965812022 @default.
• W1969596581 countsByYear W19695965812023 @default.
• W1969596581 crossrefType "journal-article" @default.
• W1969596581 hasAuthorship W1969596581A5017911137 @default.
• W1969596581 hasAuthorship W1969596581A5044863989 @default.
• W1969596581 hasAuthorship W1969596581A5047782710 @default.
• W1969596581 hasAuthorship W1969596581A5060145442 @default.
• W1969596581 hasAuthorship W1969596581A5070437827 @default.
• W1969596581 hasAuthorship W1969596581A5086534495 @default.
• W1969596581 hasBestOaLocation W19695965811 @default.
• W1969596581 hasConcept C170493617 @default.
• W1969596581 hasConcept C190283241 @default.
• W1969596581 hasConcept C202751555 @default.
• W1969596581 hasConcept C203014093 @default.
• W1969596581 hasConcept C2776090121 @default.
• W1969596581 hasConcept C31573885 @default.
• W1969596581 hasConcept C54355233 @default.
• W1969596581 hasConcept C79484868 @default.
• W1969596581 hasConcept C86803240 @default.
• W1969596581 hasConcept C8891405 @default.
• W1969596581 hasConcept C95444343 @default.
• W1969596581 hasConceptScore W1969596581C170493617 @default.
• W1969596581 hasConceptScore W1969596581C190283241 @default.
• W1969596581 hasConceptScore W1969596581C202751555 @default.
• W1969596581 hasConceptScore W1969596581C203014093 @default.
• W1969596581 hasConceptScore W1969596581C2776090121 @default.
• W1969596581 hasConceptScore W1969596581C31573885 @default.
• W1969596581 hasConceptScore W1969596581C54355233 @default.
• W1969596581 hasConceptScore W1969596581C79484868 @default.
• W1969596581 hasConceptScore W1969596581C86803240 @default.
• W1969596581 hasConceptScore W1969596581C8891405 @default.
• W1969596581 hasConceptScore W1969596581C95444343 @default.
• W1969596581 hasIssue "11" @default.
• W1969596581 hasLocation W19695965811 @default.

• next