Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969599748> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1969599748 abstract "It is reported that alpha 1-adrenoceptors located in the renal vasculature and renal tubules play a major role in mediating antinatriuretic response to renal nerve stimulation as well as to the infusion of alpha 1-adrenoceptor agonist. In the present study intrarenal infusion of alpha 1-adrenoceptor agonist phenylephrine (0.25 microgram/kg/min) to Inactin-anesthetized Sprague-Dawley rats produced approximately 50% reduction in urine output, Na+ excretion and glomerular filtration rate without causing significant alterations in mean blood pressure, heart rate and fractional Na+ excretion. These changes were completely abolished by prior intrarenal infusion of prazosin (0.5 microgram/kg/min for 30 min). In separate groups of experiments, the animals received either a selective irreversible alpha 1A-adrenoceptor antagonist, SZL-49 [1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-bicyclo[2,2,2]octa-2,5- diene-2-carbonyl)piperazine], or an alpha 1B-adrenoceptor antagonist, chloroethylclonidine, intrarenally prior to phenylephrine infusion. Neither SZL-49 nor chloroethylclonidine alone significantly altered glomerular filtration rate and renal electrolyte excretion. However, SZL-49 (0.15 microgram/kg/min), but not chloroethylclonidine (50 micrograms/kg/min), completely abolished phenylephrine-induced changes in urine output, Na+ excretion and glomerular filtration rate. These results demonstrate that phenylephrine decreases urine output and Na+ excretion, mainly due to a reduction in glomerular filtration rate resulting from activation of alpha 1A-adrenoceptors, and that proximal tubular alpha 1A- or alpha 1B-adrenoceptors do not appear to contribute to this response." @default.
- W1969599748 created "2016-06-24" @default.
- W1969599748 creator A5019821536 @default.
- W1969599748 creator A5085220617 @default.
- W1969599748 date "1995-12-01" @default.
- W1969599748 modified "2023-10-14" @default.
- W1969599748 title "Identification of α1-adrenoceptor subtypes involved in the antinatriuretic response to intrarenal infusion of phenylephrine" @default.
- W1969599748 cites W1954297657 @default.
- W1969599748 cites W1967090561 @default.
- W1969599748 cites W1989671470 @default.
- W1969599748 cites W2019891182 @default.
- W1969599748 cites W2071075860 @default.
- W1969599748 cites W2086818349 @default.
- W1969599748 cites W2094591629 @default.
- W1969599748 cites W2268044899 @default.
- W1969599748 cites W2282559386 @default.
- W1969599748 cites W2401452038 @default.
- W1969599748 cites W2413001977 @default.
- W1969599748 cites W2419241215 @default.
- W1969599748 cites W2469789849 @default.
- W1969599748 doi "https://doi.org/10.1016/0014-2999(95)00469-9" @default.
- W1969599748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8666018" @default.
- W1969599748 hasPublicationYear "1995" @default.
- W1969599748 type Work @default.
- W1969599748 sameAs 1969599748 @default.
- W1969599748 citedByCount "6" @default.
- W1969599748 countsByYear W19695997482012 @default.
- W1969599748 countsByYear W19695997482014 @default.
- W1969599748 crossrefType "journal-article" @default.
- W1969599748 hasAuthorship W1969599748A5019821536 @default.
- W1969599748 hasAuthorship W1969599748A5085220617 @default.
- W1969599748 hasConcept C10146269 @default.
- W1969599748 hasConcept C126322002 @default.
- W1969599748 hasConcept C134018914 @default.
- W1969599748 hasConcept C159641895 @default.
- W1969599748 hasConcept C170493617 @default.
- W1969599748 hasConcept C185592680 @default.
- W1969599748 hasConcept C2776885963 @default.
- W1969599748 hasConcept C2777952589 @default.
- W1969599748 hasConcept C2778938600 @default.
- W1969599748 hasConcept C2780648677 @default.
- W1969599748 hasConcept C71924100 @default.
- W1969599748 hasConcept C84393581 @default.
- W1969599748 hasConceptScore W1969599748C10146269 @default.
- W1969599748 hasConceptScore W1969599748C126322002 @default.
- W1969599748 hasConceptScore W1969599748C134018914 @default.
- W1969599748 hasConceptScore W1969599748C159641895 @default.
- W1969599748 hasConceptScore W1969599748C170493617 @default.
- W1969599748 hasConceptScore W1969599748C185592680 @default.
- W1969599748 hasConceptScore W1969599748C2776885963 @default.
- W1969599748 hasConceptScore W1969599748C2777952589 @default.
- W1969599748 hasConceptScore W1969599748C2778938600 @default.
- W1969599748 hasConceptScore W1969599748C2780648677 @default.
- W1969599748 hasConceptScore W1969599748C71924100 @default.
- W1969599748 hasConceptScore W1969599748C84393581 @default.
- W1969599748 hasLocation W19695997481 @default.
- W1969599748 hasLocation W19695997482 @default.
- W1969599748 hasOpenAccess W1969599748 @default.
- W1969599748 hasPrimaryLocation W19695997481 @default.
- W1969599748 hasRelatedWork W1974159986 @default.
- W1969599748 hasRelatedWork W2010332437 @default.
- W1969599748 hasRelatedWork W2023307846 @default.
- W1969599748 hasRelatedWork W2033722021 @default.
- W1969599748 hasRelatedWork W2129759033 @default.
- W1969599748 hasRelatedWork W2157193885 @default.
- W1969599748 hasRelatedWork W2158996371 @default.
- W1969599748 hasRelatedWork W2165958118 @default.
- W1969599748 hasRelatedWork W2169261951 @default.
- W1969599748 hasRelatedWork W2100782721 @default.
- W1969599748 isParatext "false" @default.
- W1969599748 isRetracted "false" @default.
- W1969599748 magId "1969599748" @default.
- W1969599748 workType "article" @default.