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• W1969607394 endingPage "2013" @default.
• W1969607394 startingPage "2008" @default.
• W1969607394 abstract "The metabolism of vitamin D3 was studied in bilaterally nephrectomized pigs and control pigs maintained for 8–10 days by daily peritoneal dialysis. Two or three pharmacological doses of vitamin D3 were given im, one on day 0 and the others on days 4, 6, or 7 of the 8- to 10-day experimental periods. Nephrectomized pigs had extremely high plasma concentrations of 24,25-dihydroxyvitarnin D3 [24,25-(OH)2D3] and 25,26- (OH)2D3 at the end of the 8- to 10-day periods; similar levels were present in control pigs. However, nephrectomized pigs had no detectable increase in plasma 25-hydroxyvitamin D3 (250HD3)-26,23-lactone concentrations throughout the experiment, in contrast with the high plasma concentrations of 25OHD3-26,23-lactone in the control pigs. Much higher plasma 25OHD3 concentrations were present in the nephrectomized pigs than in the control pigs. Plasma 1,25-(OH)2D concentrations in nephrectomized and control pigs were similar during most of the experiment, except the anephric pigs usually had significantly higher plasma 1,25-(OH)2D concentrations for several days after the vitamin D3 injections. These studies demonstrate extrarenal production of 24,25-(OH)2D3, 25,26-(OH)2D3, and possibly 1,25- (OH)2D, and kidney-dependent synthesis of 25OHD3-26,23-lactone in the pigs." @default.
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• W1969607394 date "1982-12-01" @default.
• W1969607394 modified "2023-09-26" @default.
• W1969607394 title "Metabolism of Vitamin D₃in Nephrectomized Pigs Given Pharmacological Amounts of Vitamin D₃" @default.
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• W1969607394 doi "https://doi.org/10.1210/endo-111-6-2008" @default.
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