FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969642784> ?p ?o ?g. }

• W1969642784 endingPage "328" @default.
• W1969642784 startingPage "317" @default.
• W1969642784 abstract "Background To examine whether lifetime DSM-IV diagnosis of major depressive disorder (MDD), including age at onset and number of episodes, is associated with brain atrophy in older persons without dementia. Method Within the population-based Age, Gene/Environment Susceptibility (AGES)–Reykjavik Study, 4354 persons (mean age 76 ± 5 years, 58% women) without dementia had a 1.5-T brain magnetic resonance imaging (MRI) scan. Automated brain segmentation total and regional brain volumes were calculated. History of MDD, including age at onset and number of episodes, and MDD in the past 2 weeks was diagnosed according to DSM-IV criteria using the Mini-International Neuropsychiatric Interview (MINI). Results Of the total sample, 4.5% reported a lifetime history of MDD; 1.5% had a current diagnosis of MDD (including 75% with a prior history of depression) and 3.0% had a past but no current diagnosis (remission). After adjusting for multiple covariates, compared to participants never depressed, those with current MDD (irrespective of past) had more global brain atrophy [ B = –1.25%, 95% confidence interval (CI) −2.05 to −0.44], including more gray- and white-matter atrophy in most lobes, and also more atrophy of the hippocampus and thalamus. Participants with current, first-onset MDD also had more brain atrophy ( B = –1.62%, 95% CI −3.30 to 0.05) whereas those remitted did not ( B = 0.06%, 95% CI −0.54 to 0.66). Conclusions In older persons without dementia, current MDD, irrespective of prior history, but not remitted MDD was associated with widespread gray- and white-matter brain atrophy. Prospective studies should examine whether MDD is a consequence of, or contributes to, brain volume loss and development of dementia." @default.
• W1969642784 created "2016-06-24" @default.
• W1969642784 creator A5000325789 @default.
• W1969642784 creator A5002081827 @default.
• W1969642784 creator A5016270487 @default.
• W1969642784 creator A5018378907 @default.
• W1969642784 creator A5018722034 @default.
• W1969642784 creator A5057919043 @default.
• W1969642784 creator A5074241237 @default.
• W1969642784 creator A5083365219 @default.
• W1969642784 date "2012-05-30" @default.
• W1969642784 modified "2023-10-18" @default.
• W1969642784 title "Associations of current and remitted major depressive disorder with brain atrophy: the AGES–Reykjavik Study" @default.
• W1969642784 cites W1704143532 @default.
• W1969642784 cites W1847168837 @default.
• W1969642784 cites W1945514973 @default.
• W1969642784 cites W1962996875 @default.
• W1969642784 cites W1969375208 @default.
• W1969642784 cites W1980508260 @default.
• W1969642784 cites W1981116212 @default.
• W1969642784 cites W1981491878 @default.
• W1969642784 cites W1981824915 @default.
• W1969642784 cites W1990168531 @default.
• W1969642784 cites W1992474739 @default.
• W1969642784 cites W1992571256 @default.
• W1969642784 cites W2011341420 @default.
• W1969642784 cites W2019316537 @default.
• W1969642784 cites W2024511978 @default.
• W1969642784 cites W2028173302 @default.
• W1969642784 cites W2033348549 @default.
• W1969642784 cites W2044237823 @default.
• W1969642784 cites W2045222664 @default.
• W1969642784 cites W2052295261 @default.
• W1969642784 cites W2054931962 @default.
• W1969642784 cites W2059793861 @default.
• W1969642784 cites W2061561049 @default.
• W1969642784 cites W2062539816 @default.
• W1969642784 cites W2067535960 @default.
• W1969642784 cites W2071831334 @default.
• W1969642784 cites W2072983755 @default.
• W1969642784 cites W2076143792 @default.
• W1969642784 cites W2076277579 @default.
• W1969642784 cites W2096831423 @default.
• W1969642784 cites W2112519660 @default.
• W1969642784 cites W2118197074 @default.
• W1969642784 cites W2118826874 @default.
• W1969642784 cites W2121358117 @default.
• W1969642784 cites W2129047299 @default.
• W1969642784 cites W2137944397 @default.
• W1969642784 cites W2142560075 @default.
• W1969642784 cites W2152919321 @default.
• W1969642784 cites W2158985195 @default.
• W1969642784 cites W2165279131 @default.
• W1969642784 cites W2175315174 @default.
• W1969642784 cites W89816663 @default.
• W1969642784 doi "https://doi.org/10.1017/s0033291712001110" @default.
• W1969642784 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4244840" @default.
• W1969642784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22647536" @default.
• W1969642784 hasPublicationYear "2012" @default.
• W1969642784 type Work @default.
• W1969642784 sameAs 1969642784 @default.
• W1969642784 citedByCount "29" @default.
• W1969642784 countsByYear W19696427842013 @default.
• W1969642784 countsByYear W19696427842014 @default.
• W1969642784 countsByYear W19696427842015 @default.
• W1969642784 countsByYear W19696427842016 @default.
• W1969642784 countsByYear W19696427842017 @default.
• W1969642784 countsByYear W19696427842018 @default.
• W1969642784 countsByYear W19696427842020 @default.
• W1969642784 countsByYear W19696427842022 @default.
• W1969642784 countsByYear W19696427842023 @default.
• W1969642784 crossrefType "journal-article" @default.
• W1969642784 hasAuthorship W1969642784A5000325789 @default.
• W1969642784 hasAuthorship W1969642784A5002081827 @default.
• W1969642784 hasAuthorship W1969642784A5016270487 @default.
• W1969642784 hasAuthorship W1969642784A5018378907 @default.
• W1969642784 hasAuthorship W1969642784A5018722034 @default.
• W1969642784 hasAuthorship W1969642784A5057919043 @default.
• W1969642784 hasAuthorship W1969642784A5074241237 @default.
• W1969642784 hasAuthorship W1969642784A5083365219 @default.
• W1969642784 hasBestOaLocation W19696427842 @default.
• W1969642784 hasConcept C118552586 @default.
• W1969642784 hasConcept C126322002 @default.
• W1969642784 hasConcept C126838900 @default.
• W1969642784 hasConcept C139719470 @default.
• W1969642784 hasConcept C143409427 @default.
• W1969642784 hasConcept C15744967 @default.
• W1969642784 hasConcept C162324750 @default.
• W1969642784 hasConcept C169900460 @default.
• W1969642784 hasConcept C187212893 @default.
• W1969642784 hasConcept C2776867660 @default.
• W1969642784 hasConcept C2779134260 @default.
• W1969642784 hasConcept C2779483572 @default.
• W1969642784 hasConcept C2780051608 @default.
• W1969642784 hasConcept C2781172350 @default.
• W1969642784 hasConcept C2781357127 @default.
• W1969642784 hasConcept C2908647359 @default.
• W1969642784 hasConcept C71924100 @default.

• next