Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969644667> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W1969644667 abstract "Our appreciation of the molecular pathogenesis of primary hyperparathyroidism (HPT) has seen great advances over the past decade. This improved understanding may well lead to the development of new treatment options that are specifically targeted to defective pathways. This review summarizes recent advances in the molecular basis of HPT and associated endocrinopathies, and discusses the potential for these and future findings to provide targets for alternative approaches to therapy. The only proven contributors to common sporadic HPT, by virtue of clonal genetic abnormalities, are the cyclin D1 and MEN1 genes. Cyclin D1 is an oncogene that encodes a key regulator of the cell cycle, while MEN1 is a tumor suppressor gene that has also been implicated in familial multiple endocrine neoplasia type 1 (MEN1), in which primary HPT is common. In addition, other key parathyroid regulatory pathways may play a role in HPT pathogenesis. 1,25 (OH)2-vitamin D. Ca2+ and phosphate are regarded as principal regulators of parathyroid cell proliferation and PTH secretion. Therefore, prime candidate targets include the Ca2+ sensing receptor (CASR) gene, the vitamin D receptor (VDR) gene, a putative phosphate receptor gene, their cognate gene products, and other genes or proteins involved in their respective biochemical pathways. Attempts to identify new therapies based specifically on the defective pathways in HPT could complement or eventually supplant traditional approaches." @default.
- W1969644667 created "2016-06-24" @default.
- W1969644667 creator A5049232174 @default.
- W1969644667 creator A5057775690 @default.
- W1969644667 date "2002-07-01" @default.
- W1969644667 modified "2023-09-23" @default.
- W1969644667 title "Molecular Basis of Hyperparathyroidism and Potential Targets for Drug Development" @default.
- W1969644667 doi "https://doi.org/10.2174/1568008023340686" @default.
- W1969644667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12476790" @default.
- W1969644667 hasPublicationYear "2002" @default.
- W1969644667 type Work @default.
- W1969644667 sameAs 1969644667 @default.
- W1969644667 citedByCount "5" @default.
- W1969644667 countsByYear W19696446672016 @default.
- W1969644667 crossrefType "journal-article" @default.
- W1969644667 hasAuthorship W1969644667A5049232174 @default.
- W1969644667 hasAuthorship W1969644667A5057775690 @default.
- W1969644667 hasConcept C104317684 @default.
- W1969644667 hasConcept C134018914 @default.
- W1969644667 hasConcept C179639408 @default.
- W1969644667 hasConcept C2775945674 @default.
- W1969644667 hasConcept C2779053571 @default.
- W1969644667 hasConcept C2779469564 @default.
- W1969644667 hasConcept C2780103800 @default.
- W1969644667 hasConcept C502942594 @default.
- W1969644667 hasConcept C54355233 @default.
- W1969644667 hasConcept C86803240 @default.
- W1969644667 hasConceptScore W1969644667C104317684 @default.
- W1969644667 hasConceptScore W1969644667C134018914 @default.
- W1969644667 hasConceptScore W1969644667C179639408 @default.
- W1969644667 hasConceptScore W1969644667C2775945674 @default.
- W1969644667 hasConceptScore W1969644667C2779053571 @default.
- W1969644667 hasConceptScore W1969644667C2779469564 @default.
- W1969644667 hasConceptScore W1969644667C2780103800 @default.
- W1969644667 hasConceptScore W1969644667C502942594 @default.
- W1969644667 hasConceptScore W1969644667C54355233 @default.
- W1969644667 hasConceptScore W1969644667C86803240 @default.
- W1969644667 hasLocation W19696446671 @default.
- W1969644667 hasLocation W19696446672 @default.
- W1969644667 hasOpenAccess W1969644667 @default.
- W1969644667 hasPrimaryLocation W19696446671 @default.
- W1969644667 hasRelatedWork W1944821505 @default.
- W1969644667 hasRelatedWork W1967612766 @default.
- W1969644667 hasRelatedWork W1967961914 @default.
- W1969644667 hasRelatedWork W2014148051 @default.
- W1969644667 hasRelatedWork W2016626787 @default.
- W1969644667 hasRelatedWork W2031665600 @default.
- W1969644667 hasRelatedWork W2054097028 @default.
- W1969644667 hasRelatedWork W2066253321 @default.
- W1969644667 hasRelatedWork W2066783595 @default.
- W1969644667 hasRelatedWork W2107959852 @default.
- W1969644667 hasRelatedWork W2143744713 @default.
- W1969644667 hasRelatedWork W2152350429 @default.
- W1969644667 hasRelatedWork W2165884849 @default.
- W1969644667 hasRelatedWork W2178090666 @default.
- W1969644667 hasRelatedWork W2338663355 @default.
- W1969644667 hasRelatedWork W2533829157 @default.
- W1969644667 hasRelatedWork W2599630622 @default.
- W1969644667 hasRelatedWork W2767182506 @default.
- W1969644667 hasRelatedWork W2897788101 @default.
- W1969644667 hasRelatedWork W3142020765 @default.
- W1969644667 isParatext "false" @default.
- W1969644667 isRetracted "false" @default.
- W1969644667 magId "1969644667" @default.
- W1969644667 workType "article" @default.