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• W1969650486 abstract "We administered 1-3 mg melatonin to 11 patients (eight men, three women, aged 16-46 years) with circadian rhythm sleep disorders; nine with delayed sleep phase syndrome and two with non-24-hour sleep-wake syndrome. Sleep logs were recorded throughout the study periods and actigraph and rectal temperature were monitored during treatment periods. Melatonin was administered 1-2 h before the desirable bedtime for expected phase-shifting, or 0.5-1 h before habitual bedtime for gradual advance expecting an hypnotic effect of the melatonin. Melatonin treatments were successful in 6/11 patients. Timing and dose of melatonin administration, together with its pharmacological properties for circadian rhythm sleep disorders, should be further studied." @default.
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• W1969650486 date "1998-04-01" @default.
• W1969650486 modified "2023-10-13" @default.
• W1969650486 title "Melatonin treatment for circadian rhythm sleep disorders" @default.
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• W1969650486 doi "https://doi.org/10.1111/j.1440-1819.1998.tb01063.x" @default.
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