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- W1969651010 abstract "Neural function requires effective communication between neurons and their targets at synapses. Thus, proper formation, growth and plasticity of synapses are critical to behavior. A retrograde (muscle to neuron) BMP signal is required to promote synaptic growth, homeostasis and stability at Drosophila neuromuscular junctions (NMJs).1-4 We recently demonstrated that this signal constitutes an instructive signal that sculpts synaptic growth in a graded manner and uncovered a presynaptic endocytic mechanism that modulates BMP signaling levels. In the absence of this regulation, excessive BMP signaling results in overgrown NMJs with a proliferation of ectopic boutons.5" @default.
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- W1969651010 date "2008-09-30" @default.
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- W1969651010 title "Satellite signaling at synapses" @default.
- W1969651010 doi "https://doi.org/10.4161/fly.7133" @default.
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