FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969660087> ?p ?o ?g. }

• W1969660087 endingPage "892" @default.
• W1969660087 startingPage "888" @default.
• W1969660087 abstract "The aim of this study was to evaluate the effect and elucidate the potential mechanism of the extract of rhizomes from Dioscorea alata L. cv. Phyto, Dispo85E, on accelerating the elimination of advanced glycation end products (AGEs) in vitro and in vivo. Primary mouse nonparenchymal cells (NPCs) were used to evaluate the drug effect on AGEs clearance and autophagic-lysosomal activity. In an animal study, we used AGEs-induced diabetic mice to evaluate the drug effect on AGEs-induced vascular complications. Our results indicated that Dispo85E enhanced the endocytosis and degradation activity of AGEs in hepatic NPCs. Furthermore, the hepatocyte growth factor (HGF) expression level was positively correlated with the clearance capacity of the AGEs in NPCs after Dispo85E treatment. In addition, the effects of Dispo85E on the degradation and uptake capability of (14)C-AGEs were abolished in the presence of an anti-HGF neutralizing antibody. We further demonstrated that recombinant mouse HGF could enhance the endocytosis and autophagic clearance of AGEs in NPCs. The in vivo data indicated that Dispo85E increased hepatic HGF messenger RNA expression levels and decreased serum AGEs level in diabetic mice. Moreover, the function of retina and kidneys was improved by Dispo85E treatment in AGEs-induced diabetic mice. These results suggest that HGF may have an important role in the elimination of AGEs. This study suggests that Dispo85E is a botanical drug with a novel mechanism that enhances the clearance of AGEs through HGF-induced autophagic-lysosomal pathway and is a candidate drug for the treatment of diabetic vascular complications." @default.
• W1969660087 created "2016-06-24" @default.
• W1969660087 creator A5023141196 @default.
• W1969660087 creator A5025303053 @default.
• W1969660087 creator A5029854651 @default.
• W1969660087 creator A5074580585 @default.
• W1969660087 creator A5079191626 @default.
• W1969660087 date "2011-06-01" @default.
• W1969660087 modified "2023-09-30" @default.
• W1969660087 title "Hepatocyte growth factor has a role in the amelioration of diabetic vascular complications via autophagic clearance of advanced glycation end products: Dispo85E, an HGF inducer, as a potential botanical drug" @default.
• W1969660087 cites W1888335775 @default.
• W1969660087 cites W1907608182 @default.
• W1969660087 cites W1980763614 @default.
• W1969660087 cites W2005782838 @default.
• W1969660087 cites W2007605191 @default.
• W1969660087 cites W2013477631 @default.
• W1969660087 cites W2042193211 @default.
• W1969660087 cites W2062686313 @default.
• W1969660087 cites W2067471569 @default.
• W1969660087 cites W2073956836 @default.
• W1969660087 cites W2106627170 @default.
• W1969660087 cites W2108086395 @default.
• W1969660087 cites W2125826913 @default.
• W1969660087 cites W2126604693 @default.
• W1969660087 cites W2134659783 @default.
• W1969660087 cites W2136390473 @default.
• W1969660087 cites W2139941678 @default.
• W1969660087 cites W2155676569 @default.
• W1969660087 cites W2167793782 @default.
• W1969660087 cites W2332563022 @default.
• W1969660087 doi "https://doi.org/10.1016/j.metabol.2010.08.009" @default.
• W1969660087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21040934" @default.
• W1969660087 hasPublicationYear "2011" @default.
• W1969660087 type Work @default.
• W1969660087 sameAs 1969660087 @default.
• W1969660087 citedByCount "18" @default.
• W1969660087 countsByYear W19696600872013 @default.
• W1969660087 countsByYear W19696600872014 @default.
• W1969660087 countsByYear W19696600872016 @default.
• W1969660087 countsByYear W19696600872017 @default.
• W1969660087 countsByYear W19696600872018 @default.
• W1969660087 countsByYear W19696600872019 @default.
• W1969660087 countsByYear W19696600872020 @default.
• W1969660087 countsByYear W19696600872022 @default.
• W1969660087 crossrefType "journal-article" @default.
• W1969660087 hasAuthorship W1969660087A5023141196 @default.
• W1969660087 hasAuthorship W1969660087A5025303053 @default.
• W1969660087 hasAuthorship W1969660087A5029854651 @default.
• W1969660087 hasAuthorship W1969660087A5074580585 @default.
• W1969660087 hasAuthorship W1969660087A5079191626 @default.
• W1969660087 hasConcept C104317684 @default.
• W1969660087 hasConcept C126322002 @default.
• W1969660087 hasConcept C134018914 @default.
• W1969660087 hasConcept C147990577 @default.
• W1969660087 hasConcept C150903083 @default.
• W1969660087 hasConcept C170493617 @default.
• W1969660087 hasConcept C181199279 @default.
• W1969660087 hasConcept C185592680 @default.
• W1969660087 hasConcept C190283241 @default.
• W1969660087 hasConcept C202751555 @default.
• W1969660087 hasConcept C203522944 @default.
• W1969660087 hasConcept C207001950 @default.
• W1969660087 hasConcept C2225953 @default.
• W1969660087 hasConcept C2776996007 @default.
• W1969660087 hasConcept C2776997535 @default.
• W1969660087 hasConcept C2780216420 @default.
• W1969660087 hasConcept C28005876 @default.
• W1969660087 hasConcept C55493867 @default.
• W1969660087 hasConcept C555293320 @default.
• W1969660087 hasConcept C71924100 @default.
• W1969660087 hasConcept C86803240 @default.
• W1969660087 hasConcept C98274493 @default.
• W1969660087 hasConceptScore W1969660087C104317684 @default.
• W1969660087 hasConceptScore W1969660087C126322002 @default.
• W1969660087 hasConceptScore W1969660087C134018914 @default.
• W1969660087 hasConceptScore W1969660087C147990577 @default.
• W1969660087 hasConceptScore W1969660087C150903083 @default.
• W1969660087 hasConceptScore W1969660087C170493617 @default.
• W1969660087 hasConceptScore W1969660087C181199279 @default.
• W1969660087 hasConceptScore W1969660087C185592680 @default.
• W1969660087 hasConceptScore W1969660087C190283241 @default.
• W1969660087 hasConceptScore W1969660087C202751555 @default.
• W1969660087 hasConceptScore W1969660087C203522944 @default.
• W1969660087 hasConceptScore W1969660087C207001950 @default.
• W1969660087 hasConceptScore W1969660087C2225953 @default.
• W1969660087 hasConceptScore W1969660087C2776996007 @default.
• W1969660087 hasConceptScore W1969660087C2776997535 @default.
• W1969660087 hasConceptScore W1969660087C2780216420 @default.
• W1969660087 hasConceptScore W1969660087C28005876 @default.
• W1969660087 hasConceptScore W1969660087C55493867 @default.
• W1969660087 hasConceptScore W1969660087C555293320 @default.
• W1969660087 hasConceptScore W1969660087C71924100 @default.
• W1969660087 hasConceptScore W1969660087C86803240 @default.
• W1969660087 hasConceptScore W1969660087C98274493 @default.
• W1969660087 hasIssue "6" @default.
• W1969660087 hasLocation W19696600871 @default.
• W1969660087 hasLocation W19696600872 @default.
• W1969660087 hasOpenAccess W1969660087 @default.

• next