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- W1969661569 abstract "This study was performed to evaluate the effect of <i>L</i>-arginine (<i>L</i>-Arg) on the prevention of chronic cyclosporine (CsA) nephrotoxicity in rats. Rats pair-fed a low-salt diet (0.05%) were given CsA (15 mg/kg/day s.c.), CsA and <i>L</i>-Arg (<i>L</i>-Arg group, 1.25 g/l water), CsA and N-nitro-<i>L</i>-arginine methyl ester (<i>L</i>-NAME group, 70 mg/l water) or vehicle. After 28 days, the <i>L</i>-Arg group had a higher glomerular filtration rate compared to the CsA (0.42±0.05 vs. 0.31±0.06 ml/min/100 g, p < 0.05) and the <i>L</i>-NAME groups (vs. 0.19± 0.04 ml/min/100 g, p < 0.05) and a significantly lower serum creatinine level compared to the CsA (0.70±0.06 vs. 0.92±0.12 mg/dl, p < 0.05) and the <i>L</i>-NAME groups (vs. 1.21±0.17 mg/dl, p < 0.05). The <i>L</i>-Arg group had less fibrosis, tubular injury (TI), and arteriolopathy than the CsA (fibrosis 0.39±0.14 vs. 0.74±0.15; TI 1.3±0.3 vs. 2.0±0.1; arteriolopathy 33±7 vs. 48±17, p < 0.05, respectively) and the <i>L</i>-NAME groups (fibrosis vs. 1.67±0.32, TI vs. 2.6±0.3, arteriolopathy vs. 63±10, p < 0.05, respectively). Plasma renin activity in the <i>L</i>-Arg group was less than in the CsA (18±2 vs. 23±3 ng Ang I/ml/h, p < 0.05) and the <i>L</i>-NAME groups (vs. 30±3 ng Ang I/ml/h, p < 0.05). Nitric oxide production in <i>L</i>-Arg group was higher than in the CsA (24.2±1.7 vs. 11.1±1.5 µmol/24 h, p < 0.05) and the <i>L</i>-NAME groups (vs. 8.4±1.0 µmol/24 h, p < 0.05). In conclusion, the nitric oxide pathway is associated with the pathogenesis of chronic CsA nephrotoxicity, and exogenous <i>L</i>-Arg supplementation is effective in reducing chronic CsA nephrotoxicity in rats." @default.
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- W1969661569 date "1998-02-04" @default.
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- W1969661569 title "Oral Supplementation of L-Arginine Prevents Chronic Cyclosporine Nephrotoxicity in Rats" @default.
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