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- W1969669209 abstract "Abstract The steroid cholecalciferol or vitamin D 3 is known to undergo a successive two-step hydroxylation, first in the liver to give 25-OH-D 3 and then in the kidney to produce 1α,25-(OH) 2 -D 3 . The kidney is postulated to be the endocrine gland which produces the biologically active form of vitamin D. The biological response to 1α,25-(OH) 2 -D 3 in the target intestine is believed to occur as a consequence of association with cytoplasmic and nuclear receptors, as is the case for other classical steroid hormones. A steroid competition assay has been devised using receptors present in the intestinal chromatin. A comparison of the relative competition in the assay and biological activity of a variety of analogs has defined some of the essential structural elements required for vitamin D activity. These structure-function relationships of analogs of 1α,25-(OH) 2 -D 3 are also discussed with particular emphasis on the A-ring conformation. It is emphasized that the A-ring of these seco-steroids consist of a pair of rapidly equilibrating chair conformers. As a consequence, different chair conformations produce different orientations of substituent groups in the A-ring. It is proposed that the 1α-hydroxyl of 1α,25-dihydroxyvitamin D 3 or its geometric equivalent in analogs must occupy the equatorial as opposed to the axial orientation for optimization of biological activity." @default.
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- W1969669209 date "1975-03-01" @default.
- W1969669209 modified "2023-09-25" @default.
- W1969669209 title "Structure-function studies of the interaction of the hormonally active form of vitamin D3, 1α,25-dihydroxy-vitamin D3, with the intestine" @default.
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- W1969669209 doi "https://doi.org/10.1016/0022-4731(75)90173-9" @default.
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