FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969674302> ?p ?o ?g. }

• W1969674302 endingPage "S42" @default.
• W1969674302 startingPage "S38" @default.
• W1969674302 abstract "It is well established that exposure to cigarette smoke (CS), through active smoking and through exposure to secondhand smoke, has immunosuppressive effects, yet how this might affect the microbiome is not known. In this manuscript we focus on the effects of CS on innate host defense response, with particular emphasis on the role of epithelial cells and mucosal immune responses in the nose and the potential effects on the microbiome. The studies described here briefly summarize the effects of CS on specific innate immune cells, such as neutrophils, macrophages/monocytes, natural killer cells, and dendritic cells. A detailed description of how CS affects epithelial cells and why we consider this to be a central defect in the overall immunosuppressive effects of CS in the lung is provided. We summarize data on the role of the epimmunome in the context of CS exposure, including the effects on soluble mediator production, such as cytokines, chemokines, and antimicrobial defense mediators. Separate emphasis is put on the expression of ligands on epithelial cells, which directly interact with receptors on immune cells, and the effects of CS on these interactions. We introduce the nose and nasal mucosa as a model to study the effects of CS exposure on host defense responses and changes in the microbiome in humans in vivo. Understanding the dynamics of a healthy microbiome and how CS affects this balance is important to uncovering the mechanisms of CS-induced disease." @default.
• W1969674302 created "2016-06-24" @default.
• W1969674302 creator A5044617284 @default.
• W1969674302 date "2014-01-01" @default.
• W1969674302 modified "2023-09-26" @default.
• W1969674302 title "Cigarette Smoke Effects on Innate Immune Mechanisms in the Nasal Mucosa. Potential Effects on the Microbiome" @default.
• W1969674302 cites W1535501919 @default.
• W1969674302 cites W1847381410 @default.
• W1969674302 cites W1965676519 @default.
• W1969674302 cites W1965971222 @default.
• W1969674302 cites W1980008048 @default.
• W1969674302 cites W1981586573 @default.
• W1969674302 cites W1984428604 @default.
• W1969674302 cites W2005825715 @default.
• W1969674302 cites W2009646322 @default.
• W1969674302 cites W2011658760 @default.
• W1969674302 cites W2015247138 @default.
• W1969674302 cites W2023385268 @default.
• W1969674302 cites W2023620934 @default.
• W1969674302 cites W2029335692 @default.
• W1969674302 cites W2035483456 @default.
• W1969674302 cites W2039194112 @default.
• W1969674302 cites W2044927291 @default.
• W1969674302 cites W2048351247 @default.
• W1969674302 cites W2058662320 @default.
• W1969674302 cites W2059228943 @default.
• W1969674302 cites W2064310561 @default.
• W1969674302 cites W2067572057 @default.
• W1969674302 cites W2068081621 @default.
• W1969674302 cites W2068332307 @default.
• W1969674302 cites W2070273791 @default.
• W1969674302 cites W2079487663 @default.
• W1969674302 cites W2081316170 @default.
• W1969674302 cites W2084292672 @default.
• W1969674302 cites W2087942502 @default.
• W1969674302 cites W2090881685 @default.
• W1969674302 cites W2097547967 @default.
• W1969674302 cites W2100604307 @default.
• W1969674302 cites W2104578295 @default.
• W1969674302 cites W2105941914 @default.
• W1969674302 cites W2108013180 @default.
• W1969674302 cites W2110503832 @default.
• W1969674302 cites W2113798118 @default.
• W1969674302 cites W2130121916 @default.
• W1969674302 cites W2132334284 @default.
• W1969674302 cites W2133491678 @default.
• W1969674302 cites W2133833187 @default.
• W1969674302 cites W2138064894 @default.
• W1969674302 cites W2138986864 @default.
• W1969674302 cites W2143112023 @default.
• W1969674302 cites W2151633680 @default.
• W1969674302 cites W2155956048 @default.
• W1969674302 cites W2159497758 @default.
• W1969674302 cites W2161015625 @default.
• W1969674302 cites W2163401084 @default.
• W1969674302 cites W2167549367 @default.
• W1969674302 cites W2170069789 @default.
• W1969674302 doi "https://doi.org/10.1513/annalsats.201306-154mg" @default.
• W1969674302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24437404" @default.
• W1969674302 hasPublicationYear "2014" @default.
• W1969674302 type Work @default.
• W1969674302 sameAs 1969674302 @default.
• W1969674302 citedByCount "46" @default.
• W1969674302 countsByYear W19696743022015 @default.
• W1969674302 countsByYear W19696743022016 @default.
• W1969674302 countsByYear W19696743022017 @default.
• W1969674302 countsByYear W19696743022018 @default.
• W1969674302 countsByYear W19696743022019 @default.
• W1969674302 countsByYear W19696743022020 @default.
• W1969674302 countsByYear W19696743022021 @default.
• W1969674302 countsByYear W19696743022022 @default.
• W1969674302 countsByYear W19696743022023 @default.
• W1969674302 crossrefType "journal-article" @default.
• W1969674302 hasAuthorship W1969674302A5044617284 @default.
• W1969674302 hasConcept C13373296 @default.
• W1969674302 hasConcept C136449434 @default.
• W1969674302 hasConcept C143121216 @default.
• W1969674302 hasConcept C151730666 @default.
• W1969674302 hasConcept C203014093 @default.
• W1969674302 hasConcept C2779343474 @default.
• W1969674302 hasConcept C60644358 @default.
• W1969674302 hasConcept C71924100 @default.
• W1969674302 hasConcept C86803240 @default.
• W1969674302 hasConcept C8891405 @default.
• W1969674302 hasConceptScore W1969674302C13373296 @default.
• W1969674302 hasConceptScore W1969674302C136449434 @default.
• W1969674302 hasConceptScore W1969674302C143121216 @default.
• W1969674302 hasConceptScore W1969674302C151730666 @default.
• W1969674302 hasConceptScore W1969674302C203014093 @default.
• W1969674302 hasConceptScore W1969674302C2779343474 @default.
• W1969674302 hasConceptScore W1969674302C60644358 @default.
• W1969674302 hasConceptScore W1969674302C71924100 @default.
• W1969674302 hasConceptScore W1969674302C86803240 @default.
• W1969674302 hasConceptScore W1969674302C8891405 @default.
• W1969674302 hasIssue "Supplement 1" @default.
• W1969674302 hasLocation W19696743021 @default.
• W1969674302 hasLocation W19696743022 @default.
• W1969674302 hasOpenAccess W1969674302 @default.

• next