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- W1969674928 abstract "Chromosomal translocations in hematologic neoplasia affect genetic aberrations resulting in fusion transcripts [ 1 Mrózek K. Heinonen K. de la Chapelle A. Bloomfield C.D. Clinical significance of cytogenetics in acute myeloid leukemia. Semin Oncol. 1997; 24: 17-31 PubMed Google Scholar , 2 Rowley J.D. The role of chromosome translocations in leukemogenesis. Semin Hematol. 1999; 36: 59-72 PubMed Google Scholar , 3 Grimwade D. Walker H. Oliver F. Wheatly K. Harrison C. Harrison G. Rees J. Hann I. Stevens R. Burnatt A. Goldstone A. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. Blood. 1998; 92: 2322-2333 Crossref PubMed Google Scholar , 4 Slovak M.L. Kopecky K.J. Cassileth P.A. Harrington D.H. Theil K.S. Mohamed A. Paietta E. Willman C.L. Head D.R. Rowe J.M. Forman S.J. Appelbaum F.R. Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group Study. Blood. 2000; 96: 4075-4083 PubMed Google Scholar ]. Therefore, the accumulation of data on simple translocations may be important for further target therapy. Here, we report a translocation in an acute myeloid leukemia (AML) (FAB-M1) with hyperleukocytosis and early relapse with central nervous system (CNS) involvement." @default.
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- W1969674928 date "2006-02-01" @default.
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- W1969674928 title "Translocation (4;9)(q11;q33), a new rearrangement in acute myeloid leukemia with central nervous system involvement" @default.
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- W1969674928 doi "https://doi.org/10.1016/j.cancergencyto.2005.10.006" @default.
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