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• W1969676810 endingPage "455" @default.
• W1969676810 startingPage "441" @default.
• W1969676810 abstract "In contrast to higher vertebrates, most fish species hatch at the embryonic stage of life. Consequently, they have to defend against a variety of micro-organisms living in their aquatic environment. This paper is focussed on the development of leucocytes functioning within this early innate system and later on in the acquired immune system (B and T cells). Most of the data are derived from cyprinid fish (zebrafish, carp), which are excellent models to study early ontogeny. Attention is also paid to the phylogeny of leucocytes, with special attention to early chordates. It is clear that young fish use innate mechanisms during the first weeks/months of their development. In zebrafish, a variety of hematopoietic genes have been sequenced which allow a detailed picture of the development of the distinct leucocytes and their precursors. In cyprinids and sea bass, the thymus is the first lymphoid organ and T cells appear to be selected there much earlier than the first detection of T cell-dependent antibody responses. The first B cells are most probably generated in head kidney. Although T cells are selected earlier than B cells, T cell independent responses occur earlier than the T cell-dependent responses. The very early (pre-thymic) appearance of T-like cells in gut of sea bass and carp suggests an extra-thymic origin of these cells. However, B cells populate the GALT much later than spleen or kidney, indicating a rather late appearance of mucosal immunity. The first plasma cells are found long after the intake of food in cyprinids, but in many marine fish they appear around the first food intake. In general, acquired immunity is not correlated to food intake." @default.
• W1969676810 created "2016-06-24" @default.
• W1969676810 creator A5004127474 @default.
• W1969676810 creator A5042924303 @default.
• W1969676810 creator A5058200937 @default.
• W1969676810 creator A5073259106 @default.
• W1969676810 date "2005-11-01" @default.
• W1969676810 modified "2023-09-30" @default.
• W1969676810 title "Phylogeny and ontogeny of fish leucocytes" @default.
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