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• W1969683921 abstract "GABAA receptors are ligand-gated Cl- ion channels and the site of action of a variety of pharmacologically and clinically important drugs. In this review evidence is summarized indicating that these drugs, by interacting with several distinct binding sites at these receptors, allosterically modulate GABA-induced Cl- ion flux. Other results indicate that the affinity, as well as the modulatory efficacy of drugs, changes with receptor composition. A though investigation of the pharmacological properties of the individual binding sites on different GABAA receptor subtypes could open new avenues for selective modulation of GABAA receptors in different brain regions." @default.
• W1969683921 created "2016-06-24" @default.
• W1969683921 creator A5089382389 @default.
• W1969683921 date "1992-01-01" @default.
• W1969683921 modified "2023-10-14" @default.
• W1969683921 title "GABAA receptors: ligand-gated Cl− ion channels modulated by multiple drug-binding sites" @default.
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• W1969683921 doi "https://doi.org/10.1016/0165-6147(92)90142-s" @default.
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