FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969691202> ?p ?o ?g. }

• W1969691202 endingPage "2302" @default.
• W1969691202 startingPage "2299" @default.
• W1969691202 abstract "We analysed the association between humoral autoreactivity to zinc transporter-8 (ZnT8) and the SLC30A8 rs13266634 polymorphism (Arg325Trp), which is located at the most distal loop in the ZnT8 protein.Autoantibodies to ZnT8 were determined by RIA in 270 patients with type 1 diabetes using ZnT8 carboxy-terminal constructs (amino acids 268-369) carrying 325Trp(CW) and 325Arg(CR) and a hybrid construct (CW-CR). Forty-four ZnT8 autoantibody-positive sera with genomic DNA were used to examine the association between reactivity to ZnT8 constructs and the rs13266634 genotype.Seventy-five patients reacted to the CW-CR hybrid construct, whereas 37 and 36 patients reacted to the CW and CR constructs, respectively. All sera positive for either CW or CR autoantibodies were positive for CW-CR autoantibodies. Among 19 patients with a 325Arg(CC) genotype, 5% had CW-specific autoantibodies, 42% had CR-specific autoantibodies and 32% had dual reactivity. Conversely, 73% of 15 patients with the 325Trp(TT) genotype had CW-specific autoantibodies, no patients had CR-specific autoantibodies and 13% had dual reactivity. Nine of the ten patients (90%) with the CT genotype reacted with either CR or CW constructs. The titre of CR autoantibodies in patients carrying the C allele was significantly higher than that in TT homozygotes (p < 0.0001). In contrast, the titre of CW autoantibodies in patients carrying a T allele was significantly higher than that in CC homozygotes (p < 0.005). No evidence of an association between rs13266634 and type 1 diabetes was observed.These results indicate that variant residue at amino acid 325 is a key determinant of humoral autoreactivity to ZnT8 and that the SLC30A8 genotype is an important determinant of autoantibody specificity." @default.
• W1969691202 created "2016-06-24" @default.
• W1969691202 creator A5007692515 @default.
• W1969691202 creator A5021813946 @default.
• W1969691202 creator A5022296901 @default.
• W1969691202 creator A5024582919 @default.
• W1969691202 creator A5044442302 @default.
• W1969691202 creator A5051561328 @default.
• W1969691202 creator A5054029531 @default.
• W1969691202 creator A5055859504 @default.
• W1969691202 creator A5058559482 @default.
• W1969691202 creator A5061340857 @default.
• W1969691202 creator A5061567216 @default.
• W1969691202 creator A5081946880 @default.
• W1969691202 creator A5090984473 @default.
• W1969691202 date "2008-10-11" @default.
• W1969691202 modified "2023-10-17" @default.
• W1969691202 title "Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes" @default.
• W1969691202 cites W1989257844 @default.
• W1969691202 cites W1990304009 @default.
• W1969691202 cites W1993312496 @default.
• W1969691202 cites W2006544095 @default.
• W1969691202 cites W2025143098 @default.
• W1969691202 cites W2083445427 @default.
• W1969691202 cites W2088878246 @default.
• W1969691202 cites W2134857194 @default.
• W1969691202 cites W4233562854 @default.
• W1969691202 cites W2093214666 @default.
• W1969691202 doi "https://doi.org/10.1007/s00125-008-1165-y" @default.
• W1969691202 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18850084" @default.
• W1969691202 hasPublicationYear "2008" @default.
• W1969691202 type Work @default.
• W1969691202 sameAs 1969691202 @default.
• W1969691202 citedByCount "65" @default.
• W1969691202 countsByYear W19696912022012 @default.
• W1969691202 countsByYear W19696912022013 @default.
• W1969691202 countsByYear W19696912022014 @default.
• W1969691202 countsByYear W19696912022015 @default.
• W1969691202 countsByYear W19696912022016 @default.
• W1969691202 countsByYear W19696912022017 @default.
• W1969691202 countsByYear W19696912022018 @default.
• W1969691202 countsByYear W19696912022019 @default.
• W1969691202 countsByYear W19696912022020 @default.
• W1969691202 countsByYear W19696912022021 @default.
• W1969691202 countsByYear W19696912022022 @default.
• W1969691202 countsByYear W19696912022023 @default.
• W1969691202 crossrefType "journal-article" @default.
• W1969691202 hasAuthorship W1969691202A5007692515 @default.
• W1969691202 hasAuthorship W1969691202A5021813946 @default.
• W1969691202 hasAuthorship W1969691202A5022296901 @default.
• W1969691202 hasAuthorship W1969691202A5024582919 @default.
• W1969691202 hasAuthorship W1969691202A5044442302 @default.
• W1969691202 hasAuthorship W1969691202A5051561328 @default.
• W1969691202 hasAuthorship W1969691202A5054029531 @default.
• W1969691202 hasAuthorship W1969691202A5055859504 @default.
• W1969691202 hasAuthorship W1969691202A5058559482 @default.
• W1969691202 hasAuthorship W1969691202A5061340857 @default.
• W1969691202 hasAuthorship W1969691202A5061567216 @default.
• W1969691202 hasAuthorship W1969691202A5081946880 @default.
• W1969691202 hasAuthorship W1969691202A5090984473 @default.
• W1969691202 hasBestOaLocation W19696912021 @default.
• W1969691202 hasConcept C104317684 @default.
• W1969691202 hasConcept C126322002 @default.
• W1969691202 hasConcept C134018914 @default.
• W1969691202 hasConcept C135763542 @default.
• W1969691202 hasConcept C159654299 @default.
• W1969691202 hasConcept C163764329 @default.
• W1969691202 hasConcept C180754005 @default.
• W1969691202 hasConcept C203014093 @default.
• W1969691202 hasConcept C2777180221 @default.
• W1969691202 hasConcept C2780130043 @default.
• W1969691202 hasConcept C54355233 @default.
• W1969691202 hasConcept C555293320 @default.
• W1969691202 hasConcept C71924100 @default.
• W1969691202 hasConcept C86803240 @default.
• W1969691202 hasConceptScore W1969691202C104317684 @default.
• W1969691202 hasConceptScore W1969691202C126322002 @default.
• W1969691202 hasConceptScore W1969691202C134018914 @default.
• W1969691202 hasConceptScore W1969691202C135763542 @default.
• W1969691202 hasConceptScore W1969691202C159654299 @default.
• W1969691202 hasConceptScore W1969691202C163764329 @default.
• W1969691202 hasConceptScore W1969691202C180754005 @default.
• W1969691202 hasConceptScore W1969691202C203014093 @default.
• W1969691202 hasConceptScore W1969691202C2777180221 @default.
• W1969691202 hasConceptScore W1969691202C2780130043 @default.
• W1969691202 hasConceptScore W1969691202C54355233 @default.
• W1969691202 hasConceptScore W1969691202C555293320 @default.
• W1969691202 hasConceptScore W1969691202C71924100 @default.
• W1969691202 hasConceptScore W1969691202C86803240 @default.
• W1969691202 hasIssue "12" @default.
• W1969691202 hasLocation W19696912021 @default.
• W1969691202 hasLocation W19696912022 @default.
• W1969691202 hasLocation W19696912023 @default.
• W1969691202 hasOpenAccess W1969691202 @default.
• W1969691202 hasPrimaryLocation W19696912021 @default.
• W1969691202 hasRelatedWork W1958625084 @default.
• W1969691202 hasRelatedWork W1996464156 @default.
• W1969691202 hasRelatedWork W2017482091 @default.

• next