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- W1969695643 abstract "Identification of new therapeutic agents for the treatment of viral diseases represents an area of active investigation. In an effort to develop new antiviral compounds, a series of 1-indanone thiosemicarbazone derivatives were synthesized. These derivatives were structurally characterized using several spectroscopic techniques and evaluated against bovine viral diarrhoea virus as a surrogate model for hepatitis C virus. Thiosemicarbazone 2m showed potent anti-bovine viral diarrhoea virus activity with a higher selectivity index (SI = 80.29) than that of ribavirin (SI = 11.64). This result determines the potentiality of these thiosemicarbazones as antiviral agents for the treatment of infections caused by other highly related members of Flaviviridae family, as hepatitis C virus." @default.
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- W1969695643 date "2008-08-01" @default.
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- W1969695643 title "New 1-indanone thiosemicarbazone derivatives active against BVDV" @default.
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- W1969695643 doi "https://doi.org/10.1016/j.ejmech.2007.10.023" @default.
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