FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969697461> ?p ?o ?g. }

• W1969697461 endingPage "2451" @default.
• W1969697461 startingPage "2445" @default.
• W1969697461 abstract "Bioluminescence imaging (BLI) has found significant use in evaluating long-term cancer therapy in small animals. We have now tested the feasibility of using BLI to assess acute effects of the vascular disrupting agent combretastatin A4 phosphate (CA4P) on luciferase-expressing MDA-MB-231 human breast tumor cells growing as xenografts in mice. Following administration of luciferin substrate, there is a rapid increase in light emission reaching a maximum after about 6 min, which gradually decreases over the following 20 min. The kinetics of light emission are highly reproducible; however, following i.p. administration of CA4P (120 mg/kg), the detected light emission was decreased between 50 and 90%, and time to maximum was significantly delayed. Twenty-four hours later, there was some recovery of light emission following further administration of luciferin substrate. Comparison with dynamic contrast-enhanced MRI based on the paramagnetic contrast agent Omniscan showed comparable changes in the tumors consistent with the previous literature. Histology also confirmed shutdown of tumor vascular perfusion. We believe this finding provides an important novel application for BLI that could have widespread application in screening novel therapeutics expected to cause acute vascular changes in tumors." @default.
• W1969697461 created "2016-06-24" @default.
• W1969697461 creator A5019397773 @default.
• W1969697461 creator A5042028269 @default.
• W1969697461 creator A5079903309 @default.
• W1969697461 creator A5090381580 @default.
• W1969697461 date "2008-02-08" @default.
• W1969697461 modified "2023-10-02" @default.
• W1969697461 title "Antivascular effects of combretastatin A4 phosphate in breast cancer xenograft assessed using dynamic bioluminescence imaging and confirmed by MRI" @default.
• W1969697461 cites W1977854955 @default.
• W1969697461 cites W1990721782 @default.
• W1969697461 cites W1994590301 @default.
• W1969697461 cites W2002227254 @default.
• W1969697461 cites W2007854922 @default.
• W1969697461 cites W2015501243 @default.
• W1969697461 cites W2031822198 @default.
• W1969697461 cites W2035074260 @default.
• W1969697461 cites W2036564049 @default.
• W1969697461 cites W2038145387 @default.
• W1969697461 cites W2055920723 @default.
• W1969697461 cites W2056944384 @default.
• W1969697461 cites W2057910790 @default.
• W1969697461 cites W2060578335 @default.
• W1969697461 cites W2062036842 @default.
• W1969697461 cites W2064134350 @default.
• W1969697461 cites W2064421914 @default.
• W1969697461 cites W2065012409 @default.
• W1969697461 cites W2072303914 @default.
• W1969697461 cites W2084261621 @default.
• W1969697461 cites W2085424558 @default.
• W1969697461 cites W2094868914 @default.
• W1969697461 cites W2100255475 @default.
• W1969697461 cites W2103937028 @default.
• W1969697461 cites W2125343208 @default.
• W1969697461 cites W2148132443 @default.
• W1969697461 cites W2152574565 @default.
• W1969697461 cites W2156363348 @default.
• W1969697461 cites W2171039534 @default.
• W1969697461 doi "https://doi.org/10.1096/fj.07-103713" @default.
• W1969697461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4426986" @default.
• W1969697461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18263704" @default.
• W1969697461 hasPublicationYear "2008" @default.
• W1969697461 type Work @default.
• W1969697461 sameAs 1969697461 @default.
• W1969697461 citedByCount "57" @default.
• W1969697461 countsByYear W19696974612012 @default.
• W1969697461 countsByYear W19696974612013 @default.
• W1969697461 countsByYear W19696974612014 @default.
• W1969697461 countsByYear W19696974612015 @default.
• W1969697461 countsByYear W19696974612016 @default.
• W1969697461 countsByYear W19696974612017 @default.
• W1969697461 countsByYear W19696974612018 @default.
• W1969697461 countsByYear W19696974612019 @default.
• W1969697461 countsByYear W19696974612020 @default.
• W1969697461 countsByYear W19696974612021 @default.
• W1969697461 countsByYear W19696974612022 @default.
• W1969697461 countsByYear W19696974612023 @default.
• W1969697461 crossrefType "journal-article" @default.
• W1969697461 hasAuthorship W1969697461A5019397773 @default.
• W1969697461 hasAuthorship W1969697461A5042028269 @default.
• W1969697461 hasAuthorship W1969697461A5079903309 @default.
• W1969697461 hasAuthorship W1969697461A5090381580 @default.
• W1969697461 hasBestOaLocation W19696974612 @default.
• W1969697461 hasConcept C104317684 @default.
• W1969697461 hasConcept C111335760 @default.
• W1969697461 hasConcept C121608353 @default.
• W1969697461 hasConcept C126322002 @default.
• W1969697461 hasConcept C142724271 @default.
• W1969697461 hasConcept C146957229 @default.
• W1969697461 hasConcept C161997846 @default.
• W1969697461 hasConcept C185592680 @default.
• W1969697461 hasConcept C18903297 @default.
• W1969697461 hasConcept C20418707 @default.
• W1969697461 hasConcept C2777289219 @default.
• W1969697461 hasConcept C2778275628 @default.
• W1969697461 hasConcept C2781309008 @default.
• W1969697461 hasConcept C2989005 @default.
• W1969697461 hasConcept C502942594 @default.
• W1969697461 hasConcept C5176359 @default.
• W1969697461 hasConcept C530470458 @default.
• W1969697461 hasConcept C54009773 @default.
• W1969697461 hasConcept C55493867 @default.
• W1969697461 hasConcept C71924100 @default.
• W1969697461 hasConcept C84425145 @default.
• W1969697461 hasConcept C86803240 @default.
• W1969697461 hasConcept C95444343 @default.
• W1969697461 hasConceptScore W1969697461C104317684 @default.
• W1969697461 hasConceptScore W1969697461C111335760 @default.
• W1969697461 hasConceptScore W1969697461C121608353 @default.
• W1969697461 hasConceptScore W1969697461C126322002 @default.
• W1969697461 hasConceptScore W1969697461C142724271 @default.
• W1969697461 hasConceptScore W1969697461C146957229 @default.
• W1969697461 hasConceptScore W1969697461C161997846 @default.
• W1969697461 hasConceptScore W1969697461C185592680 @default.
• W1969697461 hasConceptScore W1969697461C18903297 @default.
• W1969697461 hasConceptScore W1969697461C20418707 @default.
• W1969697461 hasConceptScore W1969697461C2777289219 @default.
• W1969697461 hasConceptScore W1969697461C2778275628 @default.

• next