Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969697609> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1969697609 endingPage "3166" @default.
- W1969697609 startingPage "3161" @default.
- W1969697609 abstract "Benzalacetone synthase (BAS) is a plant-specific chalcone synthase (CHS) superfamily type III polyketide synthase (PKS) that catalyzes a one-step decarboxylative condensation of 4-coumaroyl-CoA with malonyl-CoA. The diketide forming activity of Rheum palmatum BAS is attributed to the characteristic substitution of the conserved active-site Phe215 with Leu (numbering in Medicago sativa CHS). To further understand the structure and function of R. palmatum BAS, four site-directed mutants (C197T, C197G, G256L, and S338V) were newly constructed. All the mutants did not change the product pattern, however, the activity was 2-fold increased in S338V, while reduced to half in G256L mutant. On the other hand, the C197 mutants were functionally almost identical to wild-type BAS, excluding the possibility that the second active-site Cys is involved in the enzyme reaction. Instead, homology modeling suggested a possibility that, unlike the case of CHS, BAS utilizes an alternative pocket to lock the coumaroyl moiety for the diketide formation reaction." @default.
- W1969697609 created "2016-06-24" @default.
- W1969697609 creator A5033265063 @default.
- W1969697609 creator A5042004829 @default.
- W1969697609 creator A5042923923 @default.
- W1969697609 creator A5045857743 @default.
- W1969697609 creator A5057987343 @default.
- W1969697609 creator A5067043125 @default.
- W1969697609 date "2007-06-01" @default.
- W1969697609 modified "2023-10-14" @default.
- W1969697609 title "Structure function analysis of benzalacetone synthase from Rheum palmatum" @default.
- W1969697609 cites W1987856533 @default.
- W1969697609 cites W2001873927 @default.
- W1969697609 cites W2034776959 @default.
- W1969697609 cites W2037826258 @default.
- W1969697609 cites W2047732161 @default.
- W1969697609 cites W2052577954 @default.
- W1969697609 cites W2067141048 @default.
- W1969697609 cites W2089011164 @default.
- W1969697609 cites W2093177647 @default.
- W1969697609 cites W2112149046 @default.
- W1969697609 cites W2141158541 @default.
- W1969697609 cites W2149258924 @default.
- W1969697609 doi "https://doi.org/10.1016/j.bmcl.2007.03.029" @default.
- W1969697609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17383877" @default.
- W1969697609 hasPublicationYear "2007" @default.
- W1969697609 type Work @default.
- W1969697609 sameAs 1969697609 @default.
- W1969697609 citedByCount "26" @default.
- W1969697609 countsByYear W19696976092012 @default.
- W1969697609 countsByYear W19696976092014 @default.
- W1969697609 countsByYear W19696976092016 @default.
- W1969697609 countsByYear W19696976092018 @default.
- W1969697609 countsByYear W19696976092019 @default.
- W1969697609 countsByYear W19696976092020 @default.
- W1969697609 countsByYear W19696976092021 @default.
- W1969697609 countsByYear W19696976092022 @default.
- W1969697609 countsByYear W19696976092023 @default.
- W1969697609 crossrefType "journal-article" @default.
- W1969697609 hasAuthorship W1969697609A5033265063 @default.
- W1969697609 hasAuthorship W1969697609A5042004829 @default.
- W1969697609 hasAuthorship W1969697609A5042923923 @default.
- W1969697609 hasAuthorship W1969697609A5045857743 @default.
- W1969697609 hasAuthorship W1969697609A5057987343 @default.
- W1969697609 hasAuthorship W1969697609A5067043125 @default.
- W1969697609 hasConcept C104317684 @default.
- W1969697609 hasConcept C112243037 @default.
- W1969697609 hasConcept C143065580 @default.
- W1969697609 hasConcept C169627665 @default.
- W1969697609 hasConcept C181199279 @default.
- W1969697609 hasConcept C185592680 @default.
- W1969697609 hasConcept C2777135195 @default.
- W1969697609 hasConcept C2777763344 @default.
- W1969697609 hasConcept C2778635478 @default.
- W1969697609 hasConcept C2910079589 @default.
- W1969697609 hasConcept C41183919 @default.
- W1969697609 hasConcept C553450214 @default.
- W1969697609 hasConcept C55493867 @default.
- W1969697609 hasConcept C71240020 @default.
- W1969697609 hasConceptScore W1969697609C104317684 @default.
- W1969697609 hasConceptScore W1969697609C112243037 @default.
- W1969697609 hasConceptScore W1969697609C143065580 @default.
- W1969697609 hasConceptScore W1969697609C169627665 @default.
- W1969697609 hasConceptScore W1969697609C181199279 @default.
- W1969697609 hasConceptScore W1969697609C185592680 @default.
- W1969697609 hasConceptScore W1969697609C2777135195 @default.
- W1969697609 hasConceptScore W1969697609C2777763344 @default.
- W1969697609 hasConceptScore W1969697609C2778635478 @default.
- W1969697609 hasConceptScore W1969697609C2910079589 @default.
- W1969697609 hasConceptScore W1969697609C41183919 @default.
- W1969697609 hasConceptScore W1969697609C553450214 @default.
- W1969697609 hasConceptScore W1969697609C55493867 @default.
- W1969697609 hasConceptScore W1969697609C71240020 @default.
- W1969697609 hasFunder F4320320912 @default.
- W1969697609 hasFunder F4320334789 @default.
- W1969697609 hasIssue "11" @default.
- W1969697609 hasLocation W19696976091 @default.
- W1969697609 hasLocation W19696976092 @default.
- W1969697609 hasOpenAccess W1969697609 @default.
- W1969697609 hasPrimaryLocation W19696976091 @default.
- W1969697609 hasRelatedWork W1615452586 @default.
- W1969697609 hasRelatedWork W1987856533 @default.
- W1969697609 hasRelatedWork W2034328127 @default.
- W1969697609 hasRelatedWork W2047664771 @default.
- W1969697609 hasRelatedWork W2054628289 @default.
- W1969697609 hasRelatedWork W2082855407 @default.
- W1969697609 hasRelatedWork W2141158541 @default.
- W1969697609 hasRelatedWork W2149258924 @default.
- W1969697609 hasRelatedWork W2475156981 @default.
- W1969697609 hasRelatedWork W4243655049 @default.
- W1969697609 hasVolume "17" @default.
- W1969697609 isParatext "false" @default.
- W1969697609 isRetracted "false" @default.
- W1969697609 magId "1969697609" @default.
- W1969697609 workType "article" @default.