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- W1969699932 abstract "AR-L 115 has been shown to improve left ventricular (LV) pump function in patients with advanced congestive cardiomyopathy by the intravenous and oral routes. Since AR-L 115 effects on myocardial oxygen consumption (MV̇O 2 ) and coronary blood flow (CSF) are unknown, the hemodynamic, myocardial metabolic, and ECG responses to AR-L 115 (2 mg/kg bolus) were monitored at 9-, 14-, and 9-minute intervals in seven patients with coronary disease, exhibiting ischemia during pacing stress only. Maximal responses occurred at the fourteenth minute after AR-L 115. There were (average) increases in cardiac index by 30%, heart rate by 19%, CSF by 39%, MV̇O 2 by 34%, and LV dp dt max by 27%. There were (average) decreases in peak LV systolic pressure by 13%, LV end-diastolic pressure by 42%, systemic vascular resistance by 34%, and in coronary vascular resistance by 37%. All changes were significant ( p < 0.05). Myocardial lactate extraction, stroke work index, and stroke index remained unchanged ( p > 0.05). The modes increase in MV̇O 2 is possibly explained by the increase in contractility being partially offset by reductions in LV preload and afterload. AR-L 115-improved LV pump function was accompanied by moderate increases in MV̇O 2 and CSF but without evidence of myocardial ischemia." @default.
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- W1969699932 date "1982-12-01" @default.
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- W1969699932 title "Hemodynamic and myocardial energetic changes induced by the new cardiotonic agent, AR-L 115, in patients with coronary artery disease" @default.
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- W1969699932 doi "https://doi.org/10.1016/0002-8703(82)90159-4" @default.
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