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- W1969700439 abstract "Transient changes of spatio-temporal cytosolic calcium concentrations initiate calcium signaling for downstream physiological actions. The intracellular calcium stores serve as the major source for these calcium transients. To probe calcium release in such high calcium environments, there is a pressing need to develop calcium sensors with fast kinetic properties to fulfill the requirements for understanding calcium signaling during fast physiological events such as action potentials and EC-coupling. In this study, we will report the design of calcium binding proteins with unprecedented fast kinetics that is about two orders of magnitude faster than natural calcium binding proteins. using various spectroscopic methods, we have shown that the designed calcium binding proteins exhibit desired affinity, metal selectivity and optical properties attributed to the calcium binding induced local conformation and dynamic change in the chromophore environment. We then report the application of developed calcium sensors in variety of biological processes including extracellular calcium signaling, the store-operated calcium entry, and the calcium release dynamics from SR in skeletal muscle in aging mice." @default.
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- W1969700439 date "2013-01-01" @default.
- W1969700439 modified "2023-09-29" @default.
- W1969700439 title "Design and Application of Fluorescent Calcium Binding Proteins with Fast Kinetics" @default.
- W1969700439 doi "https://doi.org/10.1016/j.bpj.2012.11.2933" @default.
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