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• W1969700660 endingPage "1891" @default.
• W1969700660 startingPage "1877" @default.
• W1969700660 abstract "Cerebral small vessel disease (SVD) is a major cause of stroke and dementia. Pathologically, three lesions are seen: small vessel arteriopathy, lacunar infarction, and diffuse white matter injury (leukoaraiosis). Appropriate experimental models would aid in understanding these pathologic states and also in preclinical testing of therapies. The objective was to perform a systematic review of animal models of SVD and determine whether these resemble four key clinicopathologic features: (1) small, discrete infarcts; (2) small vessel arteriopathy; (3) diffuse white matter damage; (4) cognitive impairment. Fifteen different models were included, under four categories: (1) embolic injuries (injected blood clot, photochemical, detergent-evoked); (2) hypoperfusion/ischaemic injury (bilateral common carotid occlusion/stenosis, striatal endothelin-1 injection, striatal mitotoxin 3-NPA); (3) hypertension-based injuries (surgical narrowing of the aorta, or genetic mutations, usually in the renin-angiotensin system); (4) blood vessel damage (injected proteases, endothelium-targeting viral infection, or genetic mutations affecting vessel walls). Chronic hypertensive models resembled most key features of SVD, and shared the major risk factors of hypertension and age with human SVD. The most-used model was the stroke-prone spontaneously hypertensive rat (SHR-SP). No model described all features of the human disease. The optimal choice of model depends on the aspect of pathophysiology being studied." @default.
• W1969700660 created "2016-06-24" @default.
• W1969700660 creator A5014640825 @default.
• W1969700660 creator A5056940847 @default.
• W1969700660 date "2008-08-13" @default.
• W1969700660 modified "2023-10-09" @default.
• W1969700660 title "Do <i>in vivo</i> Experimental Models Reflect Human Cerebral Small Vessel Disease? a Systematic Review" @default.
• W1969700660 cites W1525974642 @default.
• W1969700660 cites W1563847798 @default.
• W1969700660 cites W1626343644 @default.
• W1969700660 cites W1839080396 @default.
• W1969700660 cites W1969232761 @default.
• W1969700660 cites W1971883260 @default.
• W1969700660 cites W1973464319 @default.
• W1969700660 cites W1973465980 @default.
• W1969700660 cites W1974673706 @default.
• W1969700660 cites W1975100930 @default.
• W1969700660 cites W1975924903 @default.
• W1969700660 cites W1976321849 @default.
• W1969700660 cites W1977163687 @default.
• W1969700660 cites W1978795335 @default.
• W1969700660 cites W1981544454 @default.
• W1969700660 cites W1983033348 @default.
• W1969700660 cites W1984079375 @default.
• W1969700660 cites W1984861347 @default.
• W1969700660 cites W1985174213 @default.
• W1969700660 cites W1985600845 @default.
• W1969700660 cites W1989300299 @default.
• W1969700660 cites W1989736688 @default.
• W1969700660 cites W1990461954 @default.
• W1969700660 cites W1994137439 @default.
• W1969700660 cites W1994591232 @default.
• W1969700660 cites W1998401874 @default.
• W1969700660 cites W2000279141 @default.
• W1969700660 cites W2002330209 @default.
• W1969700660 cites W2003565287 @default.
• W1969700660 cites W2007014187 @default.
• W1969700660 cites W2007292149 @default.
• W1969700660 cites W2007439129 @default.
• W1969700660 cites W2009359363 @default.
• W1969700660 cites W2009471887 @default.
• W1969700660 cites W2011567943 @default.
• W1969700660 cites W2011976336 @default.
• W1969700660 cites W2011977284 @default.
• W1969700660 cites W2012342018 @default.
• W1969700660 cites W2015898175 @default.
• W1969700660 cites W2024607477 @default.
• W1969700660 cites W2025507126 @default.
• W1969700660 cites W2030150937 @default.
• W1969700660 cites W2031710238 @default.
• W1969700660 cites W2032836445 @default.
• W1969700660 cites W2033455783 @default.
• W1969700660 cites W2036472881 @default.
• W1969700660 cites W2037094028 @default.
• W1969700660 cites W2038754892 @default.
• W1969700660 cites W2039238576 @default.
• W1969700660 cites W2039420052 @default.
• W1969700660 cites W2044315443 @default.
• W1969700660 cites W2045600195 @default.
• W1969700660 cites W2045836468 @default.
• W1969700660 cites W2048694123 @default.
• W1969700660 cites W2050664579 @default.
• W1969700660 cites W2053159960 @default.
• W1969700660 cites W2053410966 @default.
• W1969700660 cites W2054058695 @default.
• W1969700660 cites W2054565851 @default.
• W1969700660 cites W2055352451 @default.
• W1969700660 cites W2055539327 @default.
• W1969700660 cites W2057150555 @default.
• W1969700660 cites W2057912411 @default.
• W1969700660 cites W2061014177 @default.
• W1969700660 cites W2064906534 @default.
• W1969700660 cites W2065830665 @default.
• W1969700660 cites W2067614286 @default.
• W1969700660 cites W2068094239 @default.
• W1969700660 cites W2070530568 @default.
• W1969700660 cites W2070582606 @default.
• W1969700660 cites W2072991324 @default.
• W1969700660 cites W2074410961 @default.
• W1969700660 cites W2074645936 @default.
• W1969700660 cites W2075485349 @default.
• W1969700660 cites W2075755256 @default.
• W1969700660 cites W2075835047 @default.
• W1969700660 cites W2080110208 @default.
• W1969700660 cites W2080703076 @default.
• W1969700660 cites W2082432121 @default.
• W1969700660 cites W2084009411 @default.
• W1969700660 cites W2086212014 @default.
• W1969700660 cites W2087048365 @default.
• W1969700660 cites W2087204049 @default.
• W1969700660 cites W2092499991 @default.
• W1969700660 cites W2099863406 @default.
• W1969700660 cites W2100249813 @default.
• W1969700660 cites W2100428051 @default.
• W1969700660 cites W2101620652 @default.
• W1969700660 cites W2102813529 @default.
• W1969700660 cites W2104026222 @default.
• W1969700660 cites W2105764748 @default.

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