FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969702936> ?p ?o ?g. }

• W1969702936 endingPage "1801" @default.
• W1969702936 startingPage "1794" @default.
• W1969702936 abstract "In order to take into account the complex genomic distribution of SNP variations when identifying chromosomal regions with significant SNP effects, a single nucleotide polymorphism (SNP) association scan statistic was developed. To address the computational needs of genome wide association (GWA) studies, a fast Java application, which combines single-locus SNP tests and a scan statistic for identifying chromosomal regions with significant clusters of significant SNP effects, was developed and implemented. To illustrate this application, SNP associations were analyzed in a pharmacogenomic study of the blood pressure lowering effect of thiazide-diuretics (N=195) using the Affymetrix Human Mapping 100 K Set. 55,335 tagSNPs (pair-wise linkage disequilibrium R2<0.5) were selected to reduce the frequency correlation between SNPs. A typical workstation can complete the whole genome scan including 10,000 permutation tests within 3 h. The most significant regions locate on chromosome 3, 6, 13 and 16, two of which contain candidate genes that may be involved in the underlying drug response mechanism. The computational performance of ChromoScan-GWA and its scalability were tested with up to 1,000,000 SNPs and up to 4000 subjects. Using 10,000 permutations, the computation time grew linearly in these datasets. This scan statistic application provides a robust statistical and computational foundation for identifying genomic regions associated with disease and provides a method to compare GWA results even across different platforms." @default.
• W1969702936 created "2016-06-24" @default.
• W1969702936 creator A5039284931 @default.
• W1969702936 creator A5042121948 @default.
• W1969702936 creator A5044048476 @default.
• W1969702936 creator A5081119135 @default.
• W1969702936 creator A5086920355 @default.
• W1969702936 date "2009-03-01" @default.
• W1969702936 modified "2023-10-18" @default.
• W1969702936 title "Fast implementation of a scan statistic for identifying chromosomal patterns of genome wide association studies" @default.
• W1969702936 cites W1499959019 @default.
• W1969702936 cites W1981714996 @default.
• W1969702936 cites W2015408724 @default.
• W1969702936 cites W2025143098 @default.
• W1969702936 cites W2028561604 @default.
• W1969702936 cites W2036198235 @default.
• W1969702936 cites W2048755332 @default.
• W1969702936 cites W2077609634 @default.
• W1969702936 cites W2082122713 @default.
• W1969702936 cites W2082334764 @default.
• W1969702936 cites W2088569290 @default.
• W1969702936 cites W2098665884 @default.
• W1969702936 cites W2102945991 @default.
• W1969702936 cites W2113264471 @default.
• W1969702936 cites W2115938332 @default.
• W1969702936 cites W2122031852 @default.
• W1969702936 cites W2133969293 @default.
• W1969702936 cites W2134783591 @default.
• W1969702936 cites W2149378411 @default.
• W1969702936 cites W2149791927 @default.
• W1969702936 cites W2166774283 @default.
• W1969702936 cites W2171874894 @default.
• W1969702936 cites W4244626460 @default.
• W1969702936 cites W4245189769 @default.
• W1969702936 doi "https://doi.org/10.1016/j.csda.2008.04.013" @default.
• W1969702936 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2747781" @default.
• W1969702936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20161066" @default.
• W1969702936 hasPublicationYear "2009" @default.
• W1969702936 type Work @default.
• W1969702936 sameAs 1969702936 @default.
• W1969702936 citedByCount "9" @default.
• W1969702936 countsByYear W19697029362012 @default.
• W1969702936 countsByYear W19697029362014 @default.
• W1969702936 countsByYear W19697029362019 @default.
• W1969702936 countsByYear W19697029362020 @default.
• W1969702936 crossrefType "journal-article" @default.
• W1969702936 hasAuthorship W1969702936A5039284931 @default.
• W1969702936 hasAuthorship W1969702936A5042121948 @default.
• W1969702936 hasAuthorship W1969702936A5044048476 @default.
• W1969702936 hasAuthorship W1969702936A5081119135 @default.
• W1969702936 hasAuthorship W1969702936A5086920355 @default.
• W1969702936 hasBestOaLocation W19697029362 @default.
• W1969702936 hasConcept C104317684 @default.
• W1969702936 hasConcept C105795698 @default.
• W1969702936 hasConcept C106208931 @default.
• W1969702936 hasConcept C122060243 @default.
• W1969702936 hasConcept C135763542 @default.
• W1969702936 hasConcept C139275648 @default.
• W1969702936 hasConcept C153209595 @default.
• W1969702936 hasConcept C163691529 @default.
• W1969702936 hasConcept C186413461 @default.
• W1969702936 hasConcept C33923547 @default.
• W1969702936 hasConcept C35605836 @default.
• W1969702936 hasConcept C41008148 @default.
• W1969702936 hasConcept C54355233 @default.
• W1969702936 hasConcept C55060382 @default.
• W1969702936 hasConcept C59701697 @default.
• W1969702936 hasConcept C70721500 @default.
• W1969702936 hasConcept C86803240 @default.
• W1969702936 hasConcept C89128539 @default.
• W1969702936 hasConceptScore W1969702936C104317684 @default.
• W1969702936 hasConceptScore W1969702936C105795698 @default.
• W1969702936 hasConceptScore W1969702936C106208931 @default.
• W1969702936 hasConceptScore W1969702936C122060243 @default.
• W1969702936 hasConceptScore W1969702936C135763542 @default.
• W1969702936 hasConceptScore W1969702936C139275648 @default.
• W1969702936 hasConceptScore W1969702936C153209595 @default.
• W1969702936 hasConceptScore W1969702936C163691529 @default.
• W1969702936 hasConceptScore W1969702936C186413461 @default.
• W1969702936 hasConceptScore W1969702936C33923547 @default.
• W1969702936 hasConceptScore W1969702936C35605836 @default.
• W1969702936 hasConceptScore W1969702936C41008148 @default.
• W1969702936 hasConceptScore W1969702936C54355233 @default.
• W1969702936 hasConceptScore W1969702936C55060382 @default.
• W1969702936 hasConceptScore W1969702936C59701697 @default.
• W1969702936 hasConceptScore W1969702936C70721500 @default.
• W1969702936 hasConceptScore W1969702936C86803240 @default.
• W1969702936 hasConceptScore W1969702936C89128539 @default.
• W1969702936 hasIssue "5" @default.
• W1969702936 hasLocation W19697029361 @default.
• W1969702936 hasLocation W19697029362 @default.
• W1969702936 hasLocation W19697029363 @default.
• W1969702936 hasLocation W19697029364 @default.
• W1969702936 hasOpenAccess W1969702936 @default.
• W1969702936 hasPrimaryLocation W19697029361 @default.
• W1969702936 hasRelatedWork W1588942077 @default.
• W1969702936 hasRelatedWork W2007465096 @default.
• W1969702936 hasRelatedWork W2076132083 @default.

• next