FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969718819> ?p ?o ?g. }

• W1969718819 endingPage "1385" @default.
• W1969718819 startingPage "1378" @default.
• W1969718819 abstract "The production of cytokines by adenoids is known to be associated with inflammation of nasopharynx and the pathogenesis of otitis media with effusion. However, the role of adenoids in producing inflammatory cytokines such as interleukin-8 (IL-8) is not yet clear. In the present study, expression of IL-8 in adenoidal fibroblasts was investigated at the level of transcription factors. Further, the effects of clarithromycin, a 14-member ring macrolide, on IL-8 gene expression and nuclear factor-kappa B (NF-kappa B) activation in adenoidal fibroblasts were evaluated.In vitro study for the production of inflammatory cytokine from human adenoidal fibroblasts.Adenoidal fibroblasts were incubated with nontypeable Haemophilus influenzae endotoxin or interleukin-1 beta. Then the expression of IL-8 and the influence of NF-kappa B inhibitor and clarithromycin were evaluated. Interleukin-8 protein production was assessed by ELISA, and IL-8 messenger RNA production was measured by Northern blot analysis and reverse transcriptase-polymerase chain reaction. Activation of NF-kappa B and inhibition of its activation were determined by electrophoretic mobility shift assay.The expression of both IL-8 protein and messenger RNA in adenoidal fibroblasts was enhanced by Haemophilus influenzae endotoxin and interleukin-1 beta and was positively correlated with increases in NF-kappa B activity. Treatment of cells with the NF-kappa B inhibitor N-tosyl-(L)-phenylalanine chloromethyl ketone, as well as with clarithromycin, reduced expression of IL-8 and NF-kappa B activity in a dose-dependent manner.Results suggest that adenoidal fibroblasts produce IL-8 in response to endotoxin through NF-kappa B activation. The inhibitory effects of clarithromycin on NF-kappa B activation and IL-8 production in adenoidal fibroblasts might explain, in part, the mechanism of this drug in improving otitis media with effusion." @default.
• W1969718819 created "2016-06-24" @default.
• W1969718819 creator A5001411224 @default.
• W1969718819 creator A5031044218 @default.
• W1969718819 creator A5046610316 @default.
• W1969718819 creator A5058172307 @default.
• W1969718819 creator A5089832553 @default.
• W1969718819 creator A5091632115 @default.
• W1969718819 date "2003-08-01" @default.
• W1969718819 modified "2023-10-01" @default.
• W1969718819 title "The Role of Nuclear Factor-??B in Interleukin-8 Expression by Human Adenoidal Fibroblasts" @default.
• W1969718819 cites W1503713311 @default.
• W1969718819 cites W1968352602 @default.
• W1969718819 cites W1973071315 @default.
• W1969718819 cites W1977984401 @default.
• W1969718819 cites W1980051104 @default.
• W1969718819 cites W1985563173 @default.
• W1969718819 cites W1992605949 @default.
• W1969718819 cites W2007787190 @default.
• W1969718819 cites W2011156896 @default.
• W1969718819 cites W2015753298 @default.
• W1969718819 cites W2018411138 @default.
• W1969718819 cites W2019690306 @default.
• W1969718819 cites W2023508382 @default.
• W1969718819 cites W2028513907 @default.
• W1969718819 cites W2033141996 @default.
• W1969718819 cites W2043372033 @default.
• W1969718819 cites W2043462105 @default.
• W1969718819 cites W2049197565 @default.
• W1969718819 cites W2050058344 @default.
• W1969718819 cites W2050842860 @default.
• W1969718819 cites W2057539586 @default.
• W1969718819 cites W2058522802 @default.
• W1969718819 cites W2070849933 @default.
• W1969718819 cites W2075256290 @default.
• W1969718819 cites W2075787303 @default.
• W1969718819 cites W2097888665 @default.
• W1969718819 cites W2101316389 @default.
• W1969718819 cites W2105830611 @default.
• W1969718819 cites W2125221360 @default.
• W1969718819 cites W2128301658 @default.
• W1969718819 cites W2133660555 @default.
• W1969718819 cites W2136145410 @default.
• W1969718819 cites W2139319526 @default.
• W1969718819 cites W2141130289 @default.
• W1969718819 cites W2154402337 @default.
• W1969718819 cites W2158739460 @default.
• W1969718819 cites W2159660879 @default.
• W1969718819 cites W2171260427 @default.
• W1969718819 cites W2317520932 @default.
• W1969718819 cites W2318252891 @default.
• W1969718819 doi "https://doi.org/10.1097/00005537-200308000-00021" @default.
• W1969718819 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12897563" @default.
• W1969718819 hasPublicationYear "2003" @default.
• W1969718819 type Work @default.
• W1969718819 sameAs 1969718819 @default.
• W1969718819 citedByCount "17" @default.
• W1969718819 countsByYear W19697188192012 @default.
• W1969718819 countsByYear W19697188192015 @default.
• W1969718819 countsByYear W19697188192016 @default.
• W1969718819 countsByYear W19697188192017 @default.
• W1969718819 crossrefType "journal-article" @default.
• W1969718819 hasAuthorship W1969718819A5001411224 @default.
• W1969718819 hasAuthorship W1969718819A5031044218 @default.
• W1969718819 hasAuthorship W1969718819A5046610316 @default.
• W1969718819 hasAuthorship W1969718819A5058172307 @default.
• W1969718819 hasAuthorship W1969718819A5089832553 @default.
• W1969718819 hasAuthorship W1969718819A5091632115 @default.
• W1969718819 hasConcept C104317684 @default.
• W1969718819 hasConcept C150194340 @default.
• W1969718819 hasConcept C153911025 @default.
• W1969718819 hasConcept C203014093 @default.
• W1969718819 hasConcept C2776925733 @default.
• W1969718819 hasConcept C2778690821 @default.
• W1969718819 hasConcept C501593827 @default.
• W1969718819 hasConcept C55493867 @default.
• W1969718819 hasConcept C71924100 @default.
• W1969718819 hasConcept C74172505 @default.
• W1969718819 hasConcept C86803240 @default.
• W1969718819 hasConcept C89423630 @default.
• W1969718819 hasConceptScore W1969718819C104317684 @default.
• W1969718819 hasConceptScore W1969718819C150194340 @default.
• W1969718819 hasConceptScore W1969718819C153911025 @default.
• W1969718819 hasConceptScore W1969718819C203014093 @default.
• W1969718819 hasConceptScore W1969718819C2776925733 @default.
• W1969718819 hasConceptScore W1969718819C2778690821 @default.
• W1969718819 hasConceptScore W1969718819C501593827 @default.
• W1969718819 hasConceptScore W1969718819C55493867 @default.
• W1969718819 hasConceptScore W1969718819C71924100 @default.
• W1969718819 hasConceptScore W1969718819C74172505 @default.
• W1969718819 hasConceptScore W1969718819C86803240 @default.
• W1969718819 hasConceptScore W1969718819C89423630 @default.
• W1969718819 hasIssue "8" @default.
• W1969718819 hasLocation W19697188191 @default.
• W1969718819 hasLocation W19697188192 @default.
• W1969718819 hasOpenAccess W1969718819 @default.
• W1969718819 hasPrimaryLocation W19697188191 @default.
• W1969718819 hasRelatedWork W1981182545 @default.

• next