FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1969724103> ?p ?o ?g. }

• W1969724103 endingPage "930" @default.
• W1969724103 startingPage "918" @default.
• W1969724103 abstract "The death of insulin-secreting beta-cells that causes type I diabetes mellitus (DM) occurs in part by apoptosis, and apoptosis also contributes to progressive beta-cell dysfunction in type II DM. Recent reports indicate that ER stress-induced apoptosis contributes to beta-cell loss in diabetes. Agents that deplete ER calcium levels induce beta-cell apoptosis by a process that is independent of increases in [Ca(2+)](i). Here we report that the SERCA inhibitor thapsigargin induces apoptosis in INS-1 insulinoma cells and that this is inhibited by a bromoenol lactone (BEL) inhibitor of group VIA calcium-independent phospholipase A(2) (iPLA(2)beta). Overexpression of iPLA(2)beta amplifies thapsigargin-induced apoptosis of INS-1 cells, and this is also suppressed by BEL. The magnitude of thapsigargin-induced INS-1 cell apoptosis correlates with the level of iPLA(2)beta expression in various cell lines, and apoptosis is associated with stimulation of iPLA(2)beta activity, perinuclear accumulation of iPLA(2)beta protein and activity, and caspase-3-catalyzed cleavage of full-length 84 kDa iPLA(2)beta to a 62 kDa product that associates with nuclei. Thapsigargin also induces ceramide accumulation in INS-1 cells, and this response is amplified in cells that overexpress iPLA(2)beta. These findings indicate that iPLA(2)beta participates in ER stress-induced apoptosis, a pathway that promotes beta-cell death in diabetes." @default.
• W1969724103 created "2016-06-24" @default.
• W1969724103 creator A5015602933 @default.
• W1969724103 creator A5016384271 @default.
• W1969724103 creator A5025247782 @default.
• W1969724103 creator A5029423133 @default.
• W1969724103 creator A5033962778 @default.
• W1969724103 creator A5038207517 @default.
• W1969724103 creator A5047855118 @default.
• W1969724103 creator A5059422942 @default.
• W1969724103 creator A5060184457 @default.
• W1969724103 date "2004-01-08" @default.
• W1969724103 modified "2023-10-01" @default.
• W1969724103 title "Apoptosis of Insulin-Secreting Cells Induced by Endoplasmic Reticulum Stress Is Amplified by Overexpression of Group VIA Calcium-Independent Phospholipase A₂ (iPLA₂β) and Suppressed by Inhibition of iPLA₂β" @default.
• W1969724103 cites W1544944356 @default.
• W1969724103 cites W1566441785 @default.
• W1969724103 cites W1570888466 @default.
• W1969724103 cites W1942214720 @default.
• W1969724103 cites W1971800301 @default.
• W1969724103 cites W1972499851 @default.
• W1969724103 cites W1979636493 @default.
• W1969724103 cites W1980006301 @default.
• W1969724103 cites W1980266047 @default.
• W1969724103 cites W1982650705 @default.
• W1969724103 cites W1984299266 @default.
• W1969724103 cites W1989683994 @default.
• W1969724103 cites W2001252698 @default.
• W1969724103 cites W2002439304 @default.
• W1969724103 cites W2003474943 @default.
• W1969724103 cites W2013389100 @default.
• W1969724103 cites W2016242736 @default.
• W1969724103 cites W2016470388 @default.
• W1969724103 cites W2018866981 @default.
• W1969724103 cites W2019774786 @default.
• W1969724103 cites W2020165436 @default.
• W1969724103 cites W2030997003 @default.
• W1969724103 cites W2033775550 @default.
• W1969724103 cites W2034213169 @default.
• W1969724103 cites W2034985442 @default.
• W1969724103 cites W2038545492 @default.
• W1969724103 cites W2039416364 @default.
• W1969724103 cites W2039486174 @default.
• W1969724103 cites W2039926771 @default.
• W1969724103 cites W2040794484 @default.
• W1969724103 cites W2043944220 @default.
• W1969724103 cites W2056402278 @default.
• W1969724103 cites W2057534783 @default.
• W1969724103 cites W2058420723 @default.
• W1969724103 cites W2058511356 @default.
• W1969724103 cites W2063535351 @default.
• W1969724103 cites W2063948223 @default.
• W1969724103 cites W2065752512 @default.
• W1969724103 cites W2068192272 @default.
• W1969724103 cites W2069065093 @default.
• W1969724103 cites W2069119728 @default.
• W1969724103 cites W2069819213 @default.
• W1969724103 cites W2072139587 @default.
• W1969724103 cites W2074943389 @default.
• W1969724103 cites W2077556683 @default.
• W1969724103 cites W2077577428 @default.
• W1969724103 cites W2081954811 @default.
• W1969724103 cites W2087262804 @default.
• W1969724103 cites W2087576138 @default.
• W1969724103 cites W2093676869 @default.
• W1969724103 cites W2102909249 @default.
• W1969724103 cites W2113544353 @default.
• W1969724103 cites W2118829336 @default.
• W1969724103 cites W2119298668 @default.
• W1969724103 cites W2120134933 @default.
• W1969724103 cites W2123364745 @default.
• W1969724103 cites W2135364357 @default.
• W1969724103 cites W2149721868 @default.
• W1969724103 cites W2154202891 @default.
• W1969724103 cites W2157838094 @default.
• W1969724103 cites W2158179799 @default.
• W1969724103 cites W2161257972 @default.
• W1969724103 cites W2192080449 @default.
• W1969724103 cites W4233808990 @default.
• W1969724103 cites W4256495376 @default.
• W1969724103 cites W56426715 @default.
• W1969724103 cites W2398856355 @default.
• W1969724103 doi "https://doi.org/10.1021/bi035536m" @default.
• W1969724103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3732319" @default.
• W1969724103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14744135" @default.
• W1969724103 hasPublicationYear "2004" @default.
• W1969724103 type Work @default.
• W1969724103 sameAs 1969724103 @default.
• W1969724103 citedByCount "103" @default.
• W1969724103 countsByYear W19697241032012 @default.
• W1969724103 countsByYear W19697241032013 @default.
• W1969724103 countsByYear W19697241032014 @default.
• W1969724103 countsByYear W19697241032015 @default.
• W1969724103 countsByYear W19697241032016 @default.
• W1969724103 countsByYear W19697241032017 @default.
• W1969724103 countsByYear W19697241032018 @default.
• W1969724103 countsByYear W19697241032019 @default.
• W1969724103 countsByYear W19697241032020 @default.
• W1969724103 countsByYear W19697241032021 @default.

• next